PMID- 31131357
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231011
IS  - 2475-0328 (Electronic)
IS  - 2475-0328 (Linking)
VI  - 3
IP  - 3
DP  - 2019 May
TI  - Improvement of non-alcoholic fatty liver disease after laparoscopic sleeve 
      gastrectomy in Japanese obese patients.
PG  - 285-290
LID - 10.1002/ags3.12234 [doi]
AB  - PURPOSE: The purpose of this study was to evaluate changes in non-alcoholic fatty 
      liver disease (NAFLD) after laparoscopic sleeve gastrectomy (LSG) using computed 
      tomography (CT) images. METHODS: We analyzed data from 57 patients who underwent 
      LSG and had CTs performed before and after surgery. The patients included 34 
      women and 23 men (with an average age of 43 years); their mean preoperative 
      weight and body mass index were 120 kg and 46 kg/m(2), respectively. 
      Obesity-related health disorders included type 2 diabetes mellitus (T2DM) in 33 
      patients, hypertension in 33 and dyslipidemia in 32. We diagnosed NAFLD in cases 
      with liver to spleen ratios (L/S ratio) <0.9 on non-contrast CT images. We 
      evaluated changes in body weights, BMIs, comorbidities, metabolic parameters, L/S 
      ratios, and liver volumes after surgery. RESULTS: The mean interval between CT 
      scans before and after surgery was 26 months. The total weight loss and % excess 
      weight loss were 35 kg and 72%, respectively. The remission rates for T2DM, 
      hypertension, and dyslipidemia were 85%, 76% and 84%, respectively. After LSG, 
      the L/S ratio increased in all the patients, while all except for one had L/S 
      ratio >0.9. We diagnosed 33 out of 57 patients (58%) as having NAFLD before the 
      operation. After the operation, the L/S ratios and liver volumes were not 
      statistically different between the patients with previous NAFLD and those 
      without it. CONCLUSION: Laparoscopic sleeve gastrectomy is an effective treatment 
      for obesity-related health disorders including NAFLD in Japanese obese patients.
FAU - Endo, Yuichi
AU  - Endo Y
AUID- ORCID: 0000-0002-8792-4067
AD  - Department of Gastroenterological and Pediatric Surgery Oita University Faculty 
      of Medicine Oita Japan.
FAU - Ohta, Masayuki
AU  - Ohta M
AD  - Department of Gastroenterological and Pediatric Surgery Oita University Faculty 
      of Medicine Oita Japan.
FAU - Tada, Kazuhiro
AU  - Tada K
AUID- ORCID: 0000-0002-6611-1059
AD  - Department of Gastroenterological and Pediatric Surgery Oita University Faculty 
      of Medicine Oita Japan.
FAU - Nakanuma, Hiroaki
AU  - Nakanuma H
AD  - Department of Gastroenterological and Pediatric Surgery Oita University Faculty 
      of Medicine Oita Japan.
FAU - Saga, Kunihiro
AU  - Saga K
AD  - Department of Gastroenterological and Pediatric Surgery Oita University Faculty 
      of Medicine Oita Japan.
FAU - Masuda, Takashi
AU  - Masuda T
AD  - Department of Gastroenterological and Pediatric Surgery Oita University Faculty 
      of Medicine Oita Japan.
FAU - Hirashita, Teijiro
AU  - Hirashita T
AUID- ORCID: 0000-0002-0252-0494
AD  - Department of Gastroenterological and Pediatric Surgery Oita University Faculty 
      of Medicine Oita Japan.
FAU - Iwashita, Yukio
AU  - Iwashita Y
AD  - Department of Gastroenterological and Pediatric Surgery Oita University Faculty 
      of Medicine Oita Japan.
FAU - Ozeki, Yoshinori
AU  - Ozeki Y
AD  - Department of Endocrinology, Metabolism, Rheumatology and Nephrology Oita 
      University Faculty of Medicine Oita Japan.
FAU - Masaki, Takayuki
AU  - Masaki T
AD  - Department of Endocrinology, Metabolism, Rheumatology and Nephrology Oita 
      University Faculty of Medicine Oita Japan.
FAU - Inomata, Masafumi
AU  - Inomata M
AD  - Department of Gastroenterological and Pediatric Surgery Oita University Faculty 
      of Medicine Oita Japan.
LA  - eng
PT  - Journal Article
DEP - 20190129
PL  - Japan
TA  - Ann Gastroenterol Surg
JT  - Annals of gastroenterological surgery
JID - 101718062
PMC - PMC6524101
OTO - NOTNLM
OT  - bariatric surgery
OT  - laparoscopic sleeve gastrectomy
OT  - liver to spleen ratio
OT  - liver volume
OT  - non-alcoholic fatty liver disease
COIS- Authors declare no conflicts of interest for this article.
EDAT- 2019/05/28 06:00
MHDA- 2019/05/28 06:01
PMCR- 2019/01/29
CRDT- 2019/05/28 06:00
PHST- 2018/10/21 00:00 [received]
PHST- 2018/12/27 00:00 [revised]
PHST- 2019/01/06 00:00 [accepted]
PHST- 2019/05/28 06:00 [entrez]
PHST- 2019/05/28 06:00 [pubmed]
PHST- 2019/05/28 06:01 [medline]
PHST- 2019/01/29 00:00 [pmc-release]
AID - AGS312234 [pii]
AID - 10.1002/ags3.12234 [doi]
PST - epublish
SO  - Ann Gastroenterol Surg. 2019 Jan 29;3(3):285-290. doi: 10.1002/ags3.12234. 
      eCollection 2019 May.