PMID- 31131543 OWN - NLM STAT- MEDLINE DCOM- 20200715 LR - 20221207 IS - 2324-9269 (Electronic) IS - 2324-9269 (Linking) VI - 7 IP - 7 DP - 2019 Jul TI - IL-7R gene polymorphisms among patients with rheumatoid arthritis: A case-control study. PG - e00738 LID - 10.1002/mgg3.738 [doi] LID - e00738 AB - BACKGROUND: Rheumatoid arthritis (RA) is the most common inflammatory disease which refers to bony erosions and joint destruction largely caused by genetic factors. Our study aimed to explore whether interleukin-7 receptor (IL-7R) gene polymorphisms influenced RA risk in the Han Chinese population. METHODS: Five single nucleotide polymorphisms (SNPs) in IL-7R gene were successfully genotyped using Agena MassARRAY platform. The associations between IL-7R polymorphisms and RA were evaluated by the Chi-squared test, T test, genetic model analysis, and haplotype analysis. We calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) using logistic regression analysis. RESULTS: Rs969129 and rs6451231 in the IL-7R gene were associated with an increased risk of RA in the allele model (OR = 1.25, 95% CI = 1.05-1.49, p = 0.013; OR = 1.23, 95% CI = 1.03-1.48, p = 0.023), respectively. In the genetic models, rs969129 and rs6451231 were associated with an increased risk of RA. After stratification analysis by age, rs969129 and rs6451231 were associated with an increased risk of RA in patients (age <54). After stratification analysis by gender, rs6451231 was associated with an increased risk of RA in males, while rs969129 was found to be associated with an elevated risk of RA in females. And there was a strong linkage disequilibrium among the four SNPs (rs969129, rs118137916, rs10053847, and rs6451231). CONCLUSION: These results suggested rs969129 and rs6451231 in the IL-7R gene were associated with an increased risk of RA in the Han Chinese population. CI - (c) 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc. FAU - Bai, Mei AU - Bai M AD - Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, Xianyang, China. AD - Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, Xianyang, China. AD - Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China. FAU - He, Xue AU - He X AD - Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, Xianyang, China. AD - Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, Xianyang, China. AD - Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China. FAU - He, Yongjun AU - He Y AD - Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, Xianyang, China. AD - Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, Xianyang, China. AD - Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China. FAU - Yuan, Dongya AU - Yuan D AD - Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, Xianyang, China. AD - Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, Xianyang, China. AD - Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China. FAU - Jin, Tianbo AU - Jin T AD - Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, Xianyang, China. AD - Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, Xianyang, China. AD - Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China. AD - Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, School of Life Sciences, Northwest University, Xi'an, Shaanxi, China. FAU - Wang, Li AU - Wang L AUID- ORCID: 0000-0003-3525-0301 AD - Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, Xianyang, China. AD - Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, Xianyang, China. AD - Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190526 PL - United States TA - Mol Genet Genomic Med JT - Molecular genetics & genomic medicine JID - 101603758 RN - 0 (Receptors, Interleukin-7) SB - IM MH - Adult MH - Aged MH - Alleles MH - Arthritis, Rheumatoid/*genetics MH - Asian People/genetics MH - Case-Control Studies MH - China/epidemiology MH - Ethnicity/genetics MH - Female MH - Gene Frequency/genetics MH - Genetic Association Studies MH - Genetic Predisposition to Disease/genetics MH - Genotype MH - Haplotypes/genetics MH - Humans MH - Linkage Disequilibrium/genetics MH - Male MH - Middle Aged MH - Odds Ratio MH - Polymorphism, Single Nucleotide/genetics MH - Receptors, Interleukin-7/*genetics/metabolism MH - Risk Factors PMC - PMC6625337 OTO - NOTNLM OT - Han Chinese population OT - case-control study OT - interleukin-7 receptor (IL-7R) OT - rheumatoid arthritis OT - single nucleotide polymorphisms (SNPs) COIS- We declare that we have no potential conflicts of interest. EDAT- 2019/05/28 06:00 MHDA- 2020/07/16 06:00 PMCR- 2019/05/26 CRDT- 2019/05/28 06:00 PHST- 2019/03/07 00:00 [received] PHST- 2019/04/16 00:00 [revised] PHST- 2019/04/18 00:00 [accepted] PHST- 2019/05/28 06:00 [pubmed] PHST- 2020/07/16 06:00 [medline] PHST- 2019/05/28 06:00 [entrez] PHST- 2019/05/26 00:00 [pmc-release] AID - MGG3738 [pii] AID - 10.1002/mgg3.738 [doi] PST - ppublish SO - Mol Genet Genomic Med. 2019 Jul;7(7):e00738. doi: 10.1002/mgg3.738. Epub 2019 May 26.