PMID- 31132177
OWN - NLM
STAT- MEDLINE
DCOM- 20200311
LR  - 20200311
IS  - 1468-3083 (Electronic)
IS  - 0926-9959 (Print)
IS  - 0926-9959 (Linking)
VI  - 33
IP  - 10
DP  - 2019 Oct
TI  - Surgical outcomes and the impact of major surgery on quality of life, activity 
      impairment and sexual health in hidradenitis suppurativa patients: a prospective 
      single centre study.
PG  - 1941-1946
LID - 10.1111/jdv.15706 [doi]
AB  - BACKGROUND: Hidradenitis suppurativa (HS) is a chronic debilitating skin disease, 
      frequently located in the groin and anogenital area, leading to a substantial 
      impact on quality of life and sexual health in patients with HS. 
      Skin-tissue-sparing excision with electrosurgical peeling (STEEP) is a procedure 
      with known low recurrence rates and high patient satisfaction in retrospective 
      series. However, a prospective study to investigate the impact of any major 
      surgery on specific aspects of the quality of life has not yet been performed. 
      OBJECTIVE: To assess surgical outcomes and the effect of major surgery on the 
      general quality of life, sexual health and activity impairment in patients with 
      HS. MATERIALS AND METHODS: A single centre prospective survey study was conducted 
      among 40 patients undergoing major surgery. Surveys were completed prior to the 
      surgery and 2, 6, 12 and 26 weeks after surgery. Besides the objective parameters 
      (time to wound closure and surface of the wound), patient-reported outcomes were 
      reported. RESULTS: Thirty-nine patients with a total of 171 survey responses were 
      included for analysis. Patients with Hurley stage I or II had a shorter time to 
      wound closure (TTWC) compared to patients with Hurley stage III (P = 0.005). TTWC 
      was significantly prolonged in patients treated with biologics (P < 0.001). 
      Smoking did not significantly influence TTWC. For patient-reported outcomes, DLQI 
      and ASEX scores did not significantly improve during the study period of 
      6 months. However, activity and overall work impairment showed considerable 
      improvement after surgery. CONCLUSION: Time to wound closure is significantly 
      prolonged by higher Hurley stage and treatment with biologics, contrastingly not 
      by smoking. Major surgery improved the overall work and daily activity 
      impairment.
CI  - (c) 2019 The Authors. Journal of the European Academy of Dermatology and 
      Venereology published by John Wiley & Sons Ltd on behalf of European Academy of 
      Dermatology and Venereology.
FAU - Prens, L M
AU  - Prens LM
AUID- ORCID: 0000-0002-3751-684X
AD  - Department of Dermatology, University Medical Center Groningen, University of 
      Groningen, Groningen, The Netherlands.
FAU - Huizinga, J
AU  - Huizinga J
AD  - Department of Dermatology, University Medical Center Groningen, University of 
      Groningen, Groningen, The Netherlands.
FAU - Janse, I C
AU  - Janse IC
AD  - Department of Dermatology, Meander Medical Center, Amersfoort, The Netherlands.
FAU - Horvath, B
AU  - Horvath B
AD  - Department of Dermatology, University Medical Center Groningen, University of 
      Groningen, Groningen, The Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20190617
PL  - England
TA  - J Eur Acad Dermatol Venereol
JT  - Journal of the European Academy of Dermatology and Venereology : JEADV
JID - 9216037
RN  - 0 (Biological Products)
SB  - IM
MH  - *Activities of Daily Living
MH  - Adult
MH  - Biological Products/therapeutic use
MH  - Efficiency
MH  - Female
MH  - Hidradenitis Suppurativa/*complications/drug therapy/*surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Reported Outcome Measures
MH  - Prospective Studies
MH  - *Quality of Life
MH  - Severity of Illness Index
MH  - *Sexual Health
MH  - Time Factors
MH  - *Wound Healing
PMC - PMC6852185
EDAT- 2019/05/28 06:00
MHDA- 2020/03/12 06:00
PMCR- 2019/11/13
CRDT- 2019/05/28 06:00
PHST- 2019/01/17 00:00 [received]
PHST- 2019/04/05 00:00 [revised]
PHST- 2019/05/07 00:00 [accepted]
PHST- 2019/05/28 06:00 [pubmed]
PHST- 2020/03/12 06:00 [medline]
PHST- 2019/05/28 06:00 [entrez]
PHST- 2019/11/13 00:00 [pmc-release]
AID - JDV15706 [pii]
AID - 10.1111/jdv.15706 [doi]
PST - ppublish
SO  - J Eur Acad Dermatol Venereol. 2019 Oct;33(10):1941-1946. doi: 10.1111/jdv.15706. 
      Epub 2019 Jun 17.