PMID- 31132656 OWN - NLM STAT- MEDLINE DCOM- 20191030 LR - 20191030 IS - 1873-6750 (Electronic) IS - 0160-4120 (Linking) VI - 129 DP - 2019 Aug TI - Persistent organic pollutants and the incidence of type 2 diabetes in the CARLA and KORA cohort studies. PG - 221-228 LID - S0160-4120(19)30390-3 [pii] LID - 10.1016/j.envint.2019.05.030 [doi] AB - BACKGROUND: Associations between several persistent organic pollutants (POPs) and type 2 diabetes have been found in humans, but the relationship has rarely been investigated in the general population. The current nested case-control study examined internal exposure to polychlorinated biphenyls (PCB) and pesticides and the incidence of type 2 diabetes among participants of two population-based German cohort studies. METHODS: We retrospectively selected 132 incident cases of type 2 diabetes and 264 age- and sex-matched controls from the CARdiovascular Living and Aging in Halle (CARLA) study (2002-2006, East Germany) and the Cooperative Health Research in the Region of Augsburg (KORA) study (1999-2001, South Germany) based on diabetes status at follow-up examinations in 2007-2010 and 2006-08, respectively (60% male, mean age 63 and 54 years). We assessed the association between baseline POP concentrations and incident diabetes by conditional logistic regression adjusted for cohort, BMI, cholesterol, alcohol, smoking, physical activity, and parental diabetes. Additionally, we examined effect modification by sex, obesity, parental diabetes and cohort. RESULTS: In both cohorts, diabetes cases showed a higher BMI, a higher frequency of parental diabetes, and higher levels of POPs. We observed an increased chance for incident diabetes for PCB-138 and PCB-153 with an odds ratio (OR) of 1.50 (95%CI: 1.07-2.11) and 1.53 (1.15-2.04) per interquartile range increase in the respective POP. In addition, explorative results suggested higher OR for women and non-obese participants. CONCLUSIONS: Our results add to the evidence on diabetogenic effects of POPs in the general population, and warrant both policies to prevent human exposure to POPs and additional research on the adverse effects of more complex chemical mixtures. CI - Copyright (c) 2019. Published by Elsevier Ltd. FAU - Wolf, Kathrin AU - Wolf K AD - Institute of Epidemiology, Helmholtz Zentrum Munchen, Germany; German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany. Electronic address: kathrin.wolf@helmholtz-muenchen.de. FAU - Bongaerts, Brenda W C AU - Bongaerts BWC AD - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany; Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Dusseldorf, Germany. FAU - Schneider, Alexandra AU - Schneider A AD - Institute of Epidemiology, Helmholtz Zentrum Munchen, Germany; German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany. FAU - Huth, Cornelia AU - Huth C AD - Institute of Epidemiology, Helmholtz Zentrum Munchen, Germany; German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany. FAU - Meisinger, Christa AU - Meisinger C AD - Chair of Epidemiology, LMU Munich, UNIKA-T Augsburg, Germany. FAU - Peters, Annette AU - Peters A AD - Institute of Epidemiology, Helmholtz Zentrum Munchen, Germany; German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany. FAU - Schneider, Andrea AU - Schneider A AD - Institute of Epidemiology, Helmholtz Zentrum Munchen, Germany. FAU - Wittsiepe, Jurgen AU - Wittsiepe J AD - Former: Department of Hygiene, Social and Environmental Medicine, Ruhr-University Bochum, Germany. FAU - Schramm, Karl-Werner AU - Schramm KW AD - Molecular EXposomics, Helmholtz Zentrum Munchen, Germany. FAU - Greiser, Karin Halina AU - Greiser KH AD - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany; Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. FAU - Hartwig, Saskia AU - Hartwig S AD - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany; Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany. FAU - Kluttig, Alexander AU - Kluttig A AD - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany; Institute of Medical Epidemiology, Biostatistics, and Informatics, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany. FAU - Rathmann, Wolfgang AU - Rathmann W AD - German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany; Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Dusseldorf, Germany; Medical Faculty, Heinrich Heine University, Dusseldorf, Germany. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20190524 PL - Netherlands TA - Environ Int JT - Environment international JID - 7807270 RN - 0 (Environmental Pollutants) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Diabetes Mellitus, Type 2/*epidemiology MH - Environmental Pollutants/*pharmacology MH - Female MH - Germany MH - Humans MH - Incidence MH - Logistic Models MH - Male MH - Middle Aged MH - Obesity/epidemiology MH - Odds Ratio MH - Polychlorinated Biphenyls/adverse effects MH - Retrospective Studies OTO - NOTNLM OT - Case-control study OT - Environmental contaminates OT - Epidemiology OT - Incidence OT - Type 2 diabetes EDAT- 2019/05/28 06:00 MHDA- 2019/10/31 06:00 CRDT- 2019/05/28 06:00 PHST- 2019/02/06 00:00 [received] PHST- 2019/05/10 00:00 [revised] PHST- 2019/05/11 00:00 [accepted] PHST- 2019/05/28 06:00 [pubmed] PHST- 2019/10/31 06:00 [medline] PHST- 2019/05/28 06:00 [entrez] AID - S0160-4120(19)30390-3 [pii] AID - 10.1016/j.envint.2019.05.030 [doi] PST - ppublish SO - Environ Int. 2019 Aug;129:221-228. doi: 10.1016/j.envint.2019.05.030. Epub 2019 May 24.