PMID- 31133961
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 10
DP  - 2019
TI  - Variability in Total Cholesterol Concentration Is Associated With the Risk of 
      Dementia: A Nationwide Population-Based Cohort Study.
PG  - 441
LID - 10.3389/fneur.2019.00441 [doi]
LID - 441
AB  - Introduction: Although total cholesterol (TC) variability is suggested as a risk 
      factor for cardiovascular and cerebrovascular disease, there is no previous study 
      to evaluate the association between TC variability and the development of 
      dementia. Methods: Using the Korean National Health Insurance Service-Health 
      Screening Cohort (NHIS-HEALS), the main outcomes were newly diagnosed all-cause 
      dementia, Alzheimer's disease (AD), or vascular dementia (VaD) between January 1, 
      2008, and December 31, 2015. Visit-to-visit TC variability was measured as 
      variability independent of the mean (TC-VIM), coefficient variance (TC-CV), and 
      standard deviation (TC-SD). Results: In a total of 131,965 Koreans, there were 
      3,722 all-cause dementia (2.82%), 2,776 AD (2.10%), and 488 VaD (0.37%) during 
      the median follow-up of 8.4 years. Kaplan-Meier curves showed increased 
      cumulative incidences for all in the group of the highest quartiles of TC 
      variability compared to the others. Regression using the Fine and Gray hazards 
      model showed a steadily increasing risk of all-cause dementia with higher 
      quartiles of TC variability. After adjusting for confounders including mean TC 
      level and comparing the highest and lowest TC-VIM quartiles, the hazard ratios 
      (HRs) for all-cause dementia and AD were 1.15 [95% confidence interval (CI) = 
      1.05-1.27; P = 0.003] and 1.12 (95% CI = 1.00-1.25; P = 0.040), respectively. The 
      incidence of VaD was not significantly higher in the higher-quartile groups 
      compared to that in the lowest-quartile group in TC-VIM variability (HR 1.22; 95% 
      CI = 0.95-1.59; P = 0.122). These associations were consistent with TC 
      variability defined by TC-CV or TC-SD. Conclusions: For the first time, we have 
      demonstrated that a higher visit-to-visit variability in TC independent of mean 
      TC is associated with an increased risk of all-cause dementia and AD in the 
      general population.
FAU - Chung, Hye Soo
AU  - Chung HS
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      College of Medicine, Hallym University, Seoul, South Korea.
FAU - Lee, Ji Sung
AU  - Lee JS
AD  - Clinical Research Center, Asan Medical Center, College of Medicine, Ulsan 
      University, Seoul, South Korea.
FAU - Kim, Jung A
AU  - Kim JA
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      College of Medicine, Korea University, Seoul, South Korea.
FAU - Roh, Eun
AU  - Roh E
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      College of Medicine, Korea University, Seoul, South Korea.
FAU - Lee, You Bin
AU  - Lee YB
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      College of Medicine, Korea University, Seoul, South Korea.
FAU - Hong, So Hyeon
AU  - Hong SH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      College of Medicine, Korea University, Seoul, South Korea.
FAU - Kim, Nam Hoon
AU  - Kim NH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      College of Medicine, Korea University, Seoul, South Korea.
FAU - Yoo, Hye Jin
AU  - Yoo HJ
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      College of Medicine, Korea University, Seoul, South Korea.
FAU - Seo, Ji A
AU  - Seo JA
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      College of Medicine, Korea University, Seoul, South Korea.
FAU - Kim, Sin Gon
AU  - Kim SG
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      College of Medicine, Korea University, Seoul, South Korea.
FAU - Kim, Nan Hee
AU  - Kim NH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      College of Medicine, Korea University, Seoul, South Korea.
FAU - Baik, Sei Hyun
AU  - Baik SH
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      College of Medicine, Korea University, Seoul, South Korea.
FAU - Choi, Kyung Mook
AU  - Choi KM
AD  - Division of Endocrinology and Metabolism, Department of Internal Medicine, 
      College of Medicine, Korea University, Seoul, South Korea.
LA  - eng
PT  - Journal Article
DEP - 20190507
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC6513975
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - dementia
OT  - total cholesterol
OT  - variability
OT  - vascular dementia
EDAT- 2019/05/28 06:00
MHDA- 2019/05/28 06:01
PMCR- 2019/05/07
CRDT- 2019/05/29 06:00
PHST- 2019/02/18 00:00 [received]
PHST- 2019/04/10 00:00 [accepted]
PHST- 2019/05/29 06:00 [entrez]
PHST- 2019/05/28 06:00 [pubmed]
PHST- 2019/05/28 06:01 [medline]
PHST- 2019/05/07 00:00 [pmc-release]
AID - 10.3389/fneur.2019.00441 [doi]
PST - epublish
SO  - Front Neurol. 2019 May 7;10:441. doi: 10.3389/fneur.2019.00441. eCollection 2019.