PMID- 31134844
OWN - NLM
STAT- MEDLINE
DCOM- 20191209
LR  - 20191217
IS  - 1532-2513 (Electronic)
IS  - 0892-3973 (Linking)
VI  - 41
IP  - 3
DP  - 2019 Jun
TI  - Pulegone inhibits inflammation via suppression of NLRP3 inflammasome and reducing 
      cytokine production in mice.
PG  - 420-427
LID - 10.1080/08923973.2019.1588292 [doi]
AB  - Context: Pulegone, a key compound in Schizonepeta essential oil, has been 
      identified as an anti-inflammatory. However, its underlying molecular mechanisms 
      on NLR family pyrin domain containing 3 (NLRP3) inflammasome have not been 
      elucidated. Objective: Here, the modulatory effects of pulegone on NLRP3 
      inflammasome were investigated. Materials and methods: The C57BL/6J mice were 
      randomly divided into five groups: Normal, Lipopolysaccharides (LPS), 
      Dexamethasone (DEX, 5 mg/kg), Pulegone (0.095 and 0.190 g/kg) groups. All mice 
      were challenged by LPS except for the Normal group. Results: A reduced expression 
      of Interleukin-18 (IL-18), Interleukin-1beta (IL-1beta), Interleukin-5 (IL-5), Tumor 
      necrosis factor-alpha (TNF-alpha), Interferon-gamma (IFN-gamma), Monocyte chemoattratctant 
      protein-1 (MCP-1), Macrophage inflammatory protein-1beta (MIP-1beta), Monocyte colony 
      stimulating factor (M-CSF) and Granulocyte-macrophage colony stimulating factor 
      (GM-CSF) in serum were detected in the pulegone groups as compared to the LPS 
      group. In addition, a reduced mRNA and protein expression production of ASC, 
      NLRP3, and Caspase-1 were detected in lungs after pulegone administration. 
      Histological analysis results indicated that the histological changes of lungs 
      caused by LPS were ameliorated by pulegone. Immunohistochemical study showed a 
      decreased positive cell numbers of P2X7R in Pulegone (0.095 and 0.190 g/kg) 
      groups. Conclusion: Pulegone exerts anti-inflammatory effects on LPS-induced 
      sepsis mice via inhibition of the NLRP3 expression.
FAU - Yang, Qingxin
AU  - Yang Q
AD  - a Department of Pharmacology, College of Pharmacy , Chengdu University of TCM , 
      Chengdu , PR China.
AD  - b Sichuan College of Traditional Chinese Medicine , Mianyang , PR China.
FAU - Luo, Jie
AU  - Luo J
AD  - a Department of Pharmacology, College of Pharmacy , Chengdu University of TCM , 
      Chengdu , PR China.
FAU - Lv, Hongjun
AU  - Lv H
AD  - a Department of Pharmacology, College of Pharmacy , Chengdu University of TCM , 
      Chengdu , PR China.
FAU - Wen, Taoqun
AU  - Wen T
AD  - a Department of Pharmacology, College of Pharmacy , Chengdu University of TCM , 
      Chengdu , PR China.
FAU - Shi, Boyu
AU  - Shi B
AD  - a Department of Pharmacology, College of Pharmacy , Chengdu University of TCM , 
      Chengdu , PR China.
FAU - Liu, Xiaobo
AU  - Liu X
AD  - a Department of Pharmacology, College of Pharmacy , Chengdu University of TCM , 
      Chengdu , PR China.
FAU - Zeng, Nan
AU  - Zeng N
AD  - a Department of Pharmacology, College of Pharmacy , Chengdu University of TCM , 
      Chengdu , PR China.
LA  - eng
PT  - Journal Article
DEP - 20190528
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (Cyclohexane Monoterpenes)
RN  - 0 (Cytokines)
RN  - 0 (Inflammasomes)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (Nlrp3 protein, mouse)
RN  - 4LF2673R3G (pulegone)
SB  - IM
MH  - Animals
MH  - Cyclohexane Monoterpenes/*pharmacology
MH  - Cytokines/*immunology
MH  - Inflammasomes/*immunology
MH  - Inflammation/chemically induced/drug therapy/immunology/pathology
MH  - Male
MH  - Mice
MH  - NLR Family, Pyrin Domain-Containing 3 Protein/*immunology
OTO - NOTNLM
OT  - LPS
OT  - NLRP3
OT  - Pulegone
OT  - inflammation
OT  - sepsis
EDAT- 2019/05/29 06:00
MHDA- 2019/12/18 06:00
CRDT- 2019/05/29 06:00
PHST- 2019/05/29 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/05/29 06:00 [entrez]
AID - 10.1080/08923973.2019.1588292 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 2019 Jun;41(3):420-427. doi: 
      10.1080/08923973.2019.1588292. Epub 2019 May 28.