PMID- 31135570
OWN - NLM
STAT- MEDLINE
DCOM- 20200113
LR  - 20200113
IS  - 1524-4725 (Electronic)
IS  - 1076-0512 (Linking)
VI  - 45
IP  - 10
DP  - 2019 Oct
TI  - Safe, Effective Chin and Jaw Restoration With VYC-25L Hyaluronic Acid Injectable 
      Gel.
PG  - 1294-1303
LID - 10.1097/DSS.0000000000001960 [doi]
AB  - BACKGROUND: VYC-25L, a hyaluronic acid soft-tissue filler with lidocaine, is 
      designed to restore and create facial volume in the chin and jaw. OBJECTIVE: To 
      evaluate the safety and effectiveness of VYC-25L in subjects with chin retrusion. 
      METHODS: Adults with chin retrusion (145 degrees -165 degrees  glabella-subnasale-pogonion facial 
      angle) were randomized (3:1) to receive VYC-25L in the chin/jaw at study onset 
      (treatment group) or 3 months later (control group). Primary effectiveness end 
      point was mean change in facial angle from baseline at Month 3. Safety 
      assessments included injection site responses (ISRs), recorded in a subject 
      diary, and adverse events (AEs). RESULTS: VYC-25L was administered to 119 
      subjects (treatment group: n = 90; control group: n = 29). Mean change in facial 
      angle from baseline at Month 3 was significantly greater in the treatment versus 
      control group (difference: 2.51 degrees ; p < .0001). Effectiveness was also demonstrated 
      by the proportion of subjects with improved/much improved Global Aesthetic 
      Improvement Scale scores and responses on FACE-Q Satisfaction and Psychological 
      Well-Being Scales. Treatment benefit remained evident at Month 12. Common ISRs 
      were firmness (95.8%), tenderness (95.8%), and swelling (91.6%). No serious 
      treatment-related AEs were reported. CONCLUSION: VYC-25L significantly improved 
      glabella-subnasale-pogonion facial angle and was generally safe and well 
      tolerated.
FAU - Ogilvie, Patricia
AU  - Ogilvie P
AD  - SkinConcept, Munich, Germany.
FAU - Sattler, Gerhard
AU  - Sattler G
AD  - Rosenpark Klinik, Darmstadt, Germany.
FAU - Gaymans, Frodo
AU  - Gaymans F
AD  - Private Practice, Amsterdam, the Netherlands.
FAU - Belhaouari, Lakhdar
AU  - Belhaouari L
AD  - Centre de Chirurgie Esthetique, Toulouse, France.
FAU - Weichman, Barry M
AU  - Weichman BM
AD  - BMW Associates, Monroe Township, New Jersey.
FAU - Snow, Sean
AU  - Snow S
AD  - Allergan plc, Irvine, California.
FAU - Chawla, Smita
AU  - Chawla S
AD  - Allergan plc, Irvine, California.
FAU - Abrams, Steve
AU  - Abrams S
AD  - Allergan plc, Irvine, California.
FAU - Schumacher, Andrew
AU  - Schumacher A
AD  - Allergan plc, Irvine, California.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PL  - United States
TA  - Dermatol Surg
JT  - Dermatologic surgery : official publication for American Society for Dermatologic 
      Surgery [et al.]
JID - 9504371
RN  - 0 (Dermal Fillers)
RN  - 0 (Drug Combinations)
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - 98PI200987 (Lidocaine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chin
MH  - Cosmetic Techniques/*adverse effects
MH  - Dermal Fillers/*administration & dosage/adverse effects
MH  - Drug Combinations
MH  - Esthetics
MH  - Female
MH  - Humans
MH  - Hyaluronic Acid/*administration & dosage/adverse effects
MH  - Injection Site Reaction/epidemiology
MH  - Jaw
MH  - Lidocaine/*administration & dosage/adverse effects
MH  - Male
MH  - Middle Aged
MH  - Patient Satisfaction
MH  - Skin Aging/*drug effects
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2019/05/29 06:00
MHDA- 2020/01/14 06:00
CRDT- 2019/05/29 06:00
PHST- 2019/05/29 06:00 [pubmed]
PHST- 2020/01/14 06:00 [medline]
PHST- 2019/05/29 06:00 [entrez]
AID - 10.1097/DSS.0000000000001960 [doi]
PST - ppublish
SO  - Dermatol Surg. 2019 Oct;45(10):1294-1303. doi: 10.1097/DSS.0000000000001960.