PMID- 31137122
OWN - NLM
STAT- MEDLINE
DCOM- 20190604
LR  - 20190604
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 99
IP  - 18
DP  - 2019 May 14
TI  - [Clinical characteristics and classification diagnosis of newly diagnosed 
      diabetes onset with ketosis or ketoacidosis in adult patients].
PG  - 1369-1374
LID - 10.3760/cma.j.issn.0376-2491.2019.18.003 [doi]
AB  - Objective: To describe the clinical characteristics and classification diagnosis 
      of newly diagnosed diabetes onset with ketosis or ketoacidosis in adult patients. 
      Methods: Medical records of newly diagnosed diabetes onset with ketosis or 
      ketoacidosis in the Third Affiliated Hospital of Sun Yat-sen University between 
      January 2011 and August 2016 were reviewed. Patients aged 18 years or older were 
      included, while other diseases that may cause urinary ketoacidosis and special 
      types of diabetes were excluded. Patients were classified as type 1 diabetes 
      mellitus (T1DM) or type 2 diabetes mellitus (T2DM) or diabetes mellitus untyped 
      based on discharged diagnosis, and groups were compared for differences in 
      clinical profiles. Then the patient's medication, final diagnosis and outcome 
      within 2 years of discharge were tracked through the inpatient and the outpatient 
      medical record systems. Receiver operating characteristics (ROC) curves were 
      analyzed to check the ability of clinical indicators such as onset age, body mass 
      index (BMI) and C-peptide to discriminate T1DM from T2DM, and to find the best 
      diagnostic cut-off points. Results: A total of 123 patients (88 males) were 
      enrolled [with a mean age of (41.1+/-13.6) years old], with 37 patients (30.1%) 
      diagnosed as T1DM, 60 patients (48.8%) diagnosed as T2DM and 26 patients (21.1%) 
      diagnosed as Untyped. There was a statistically significant difference in onset 
      age, BMI, blood pressure, blood gas pH and bicarbonate, blood lipids, fasting, 
      0.5 h and 2 h C-peptide level, any diabetic antibody and anti-glutamic acid 
      decarboxylase antibody (GADA) positive rate, combined fatty liver ratio and 
      family history among the three groups (all P<0.05). ROC curve analysis was 
      performed on patients diagnosed with T1DM (n=36) and T2DM (n=87) after 2 years 
      follow-up, and the area under the curve (AUC) of onset age, BMI, fasting 
      C-peptide, 0.5 h and 2 h C-peptide was 0.735, 0.813, 0.855, 0.898, and 0.882, 
      respectively. Conclusion: The ROC curve analysis indicates that C-peptide, onset 
      age and BMI can provide effective diagnostic value, and the diagnostic value of C 
      peptide is better than BMI and onset age.
FAU - Liu, H X
AU  - Liu HX
AD  - Department of Endocrinology and Metabolic Disease, the Third Affiliated Hospital 
      of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, 
      Guangzhou 510630, China.
FAU - Li, G M
AU  - Li GM
AD  - Department of Endocrinology, Qujing First People's Hospital, Qujing 655000, 
      Yunnan, China.
FAU - Zhou, Y W
AU  - Zhou YW
AD  - Department of Endocrinology and Metabolic Disease, the Third Affiliated Hospital 
      of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, 
      Guangzhou 510630, China.
FAU - Luo, S H
AU  - Luo SH
AD  - Department of Endocrinology and Metabolic Disease, the Third Affiliated Hospital 
      of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, 
      Guangzhou 510630, China.
FAU - Zheng, X Y
AU  - Zheng XY
AD  - Department of Endocrinology and Metabolic Disease, the Third Affiliated Hospital 
      of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, 
      Guangzhou 510630, China.
FAU - Yang, D Z
AU  - Yang DZ
AD  - Department of Endocrinology and Metabolic Disease, the Third Affiliated Hospital 
      of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, 
      Guangzhou 510630, China.
FAU - Liang, H
AU  - Liang H
AD  - Department of Endocrinology and Metabolic Disease, the Third Affiliated Hospital 
      of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, 
      Guangzhou 510630, China.
FAU - Yan, J H
AU  - Yan JH
AD  - Department of Endocrinology and Metabolic Disease, the Third Affiliated Hospital 
      of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, 
      Guangzhou 510630, China.
FAU - Yao, B
AU  - Yao B
AD  - Department of Endocrinology and Metabolic Disease, the Third Affiliated Hospital 
      of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, 
      Guangzhou 510630, China.
FAU - Weng, J P
AU  - Weng JP
AD  - Department of Endocrinology and Metabolic Disease, the Third Affiliated Hospital 
      of Sun Yat-sen University, Guangdong Provincial Key Laboratory of Diabetology, 
      Guangzhou 510630, China.
LA  - chi
GR  - 2017YFC1309603/National Key Research and Development Program of China/
GR  - 2017A070713011/Guangdong Science and Technology Plan/
GR  - 201508020027/Guangzhou Science and Technology Plan/
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (C-Peptide)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
SB  - IM
MH  - Adult
MH  - C-Peptide
MH  - *Diabetes Mellitus, Type 1
MH  - *Diabetes Mellitus, Type 2
MH  - Female
MH  - Glutamate Decarboxylase
MH  - Humans
MH  - *Ketosis
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - Diabetes mellitus, type 1
OT  - Diabetes mellitus, type 2
OT  - Diabetic ketoacidosis
EDAT- 2019/05/30 06:00
MHDA- 2019/06/05 06:00
CRDT- 2019/05/29 06:00
PHST- 2019/05/29 06:00 [entrez]
PHST- 2019/05/30 06:00 [pubmed]
PHST- 2019/06/05 06:00 [medline]
AID - 10.3760/cma.j.issn.0376-2491.2019.18.003 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2019 May 14;99(18):1369-1374. doi: 
      10.3760/cma.j.issn.0376-2491.2019.18.003.