PMID- 31137555
OWN - NLM
STAT- MEDLINE
DCOM- 20200106
LR  - 20200309
IS  - 2073-4409 (Print)
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 8
IP  - 5
DP  - 2019 May 20
TI  - Long Noncoding RNA HCP5, a Hybrid HLA Class I Endogenous Retroviral Gene: 
      Structure, Expression, and Disease Associations.
LID - 10.3390/cells8050480 [doi]
LID - 480
AB  - The HCP5 RNA gene (NCBI ID: 10866) is located centromeric of the HLA-B gene and 
      between the MICA and MICB genes within the major histocompatibility complex (MHC) 
      class I region. It is a human species-specific gene that codes for a long 
      noncoding RNA (lncRNA), composed mostly of an ancient ancestral endogenous 
      antisense 3' long terminal repeat (LTR, and part of the internal pol antisense 
      sequence of endogenous retrovirus (ERV) type 16 linked to a human leukocyte 
      antigen (HLA) class I promoter and leader sequence at the 5'-end. Since its 
      discovery in 1993, many disease association and gene expression studies have 
      shown that HCP5 is a regulatory lncRNA involved in adaptive and innate immune 
      responses and associated with the promotion of some autoimmune diseases and 
      cancers. The gene sequence acts as a genomic anchor point for binding 
      transcription factors, enhancers, and chromatin remodeling enzymes in the 
      regulation of transcription and chromatin folding. The HCP5 antisense retroviral 
      transcript also interacts with regulatory microRNA and immune and cellular 
      checkpoints in cancers suggesting its potential as a drug target for novel 
      antitumor therapeutics.
FAU - Kulski, Jerzy K
AU  - Kulski JK
AUID- ORCID: 0000-0002-9789-245X
AD  - Faculty of Health and Medical Sciences, UWA Medical School, The University of 
      Western Australia, Crawley, WA 6009, Australia. kulski@me.com.
AD  - Department of Molecular Life Science, Division of Basic Medical Science and 
      Molecular Medicine, Tokai University School of Medicine, Isehara 259-1193, Japan. 
      kulski@me.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190520
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - 0 (CCCTC-Binding Factor)
RN  - 0 (CTCF protein, human)
RN  - 0 (HCP5 long noncoding RNA, human)
RN  - 0 (HLA-B Antigens)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Autoimmune Diseases/*genetics
MH  - CCCTC-Binding Factor/genetics
MH  - Chromatin Assembly and Disassembly/genetics
MH  - Chromosome Mapping
MH  - Cytomegalovirus/genetics
MH  - Endogenous Retroviruses/*genetics
MH  - Epigenome
MH  - Gene Expression
MH  - HIV Infections/genetics
MH  - HLA-B Antigens/*genetics
MH  - Humans
MH  - Neoplasms/*genetics
MH  - Papillomaviridae/genetics
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Promoter Regions, Genetic
MH  - RNA, Long Noncoding/*genetics
PMC - PMC6562477
OTO - NOTNLM
OT  - HCP5
OT  - HLA
OT  - MHC
OT  - autoimmune diseases
OT  - cancer
OT  - competing endogenous RNA (ceRNA)
OT  - human endogenous retrovirus (HERV)
OT  - human immunodeficiency virus (HIV)
OT  - human papillomavirus (HPV)
OT  - lncRNA
COIS- The author declares no conflict of interest.
EDAT- 2019/05/30 06:00
MHDA- 2019/05/30 06:01
PMCR- 2019/05/01
CRDT- 2019/05/30 06:00
PHST- 2019/05/05 00:00 [received]
PHST- 2019/05/16 00:00 [revised]
PHST- 2019/05/17 00:00 [accepted]
PHST- 2019/05/30 06:00 [entrez]
PHST- 2019/05/30 06:00 [pubmed]
PHST- 2019/05/30 06:01 [medline]
PHST- 2019/05/01 00:00 [pmc-release]
AID - cells8050480 [pii]
AID - cells-08-00480 [pii]
AID - 10.3390/cells8050480 [doi]
PST - epublish
SO  - Cells. 2019 May 20;8(5):480. doi: 10.3390/cells8050480.