PMID- 31137560 OWN - NLM STAT- MEDLINE DCOM- 20191111 LR - 20200225 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 20 IP - 10 DP - 2019 May 20 TI - Effect of PHRs and PCPs on Microalgal Growth, Metabolism and Microalgae-Based Bioremediation Processes: A Review. LID - 10.3390/ijms20102492 [doi] LID - 2492 AB - In this review, the effect of pharmaceuticals (PHRs) and personal care products (PCPs) on microalgal growth and metabolism is reported. Concentrations of various PHRs and PCPs that cause inhibition and toxicity to growths of different microalgal strains are summarized and compared. The effect of PHRs and PCPs on microalgal metabolism (oxidative stress, enzyme activity, pigments, proteins, lipids, carbohydrates, toxins), as well as on the cellular morphology, is discussed. Literature data concerning the removal of PHRs and PCPs from wastewaters by living microalgal cultures, with the emphasis on microalgal growth, are gathered and discussed. The potential of simultaneously bioremediating PHRs/PCPs-containing wastewaters and cultivating microalgae for biomass production in a single process is considered. In the light of reviewed data, the feasibility of post-bioremediation microalgal biomass is discussed in terms of its contamination, biosafety and further usage for production of value-added biomolecules (pigments, lipids, proteins) and biomass as a whole. FAU - Miazek, Krystian AU - Miazek K AD - Institute of Applied Radiation Chemistry, Faculty of Chemistry, Lodz University of Technology, Wroblewskiego 15, 93-590 Lodz, Poland. kmiazek@mitr.p.lodz.pl. FAU - Brozek-Pluska, Beata AU - Brozek-Pluska B AD - Institute of Applied Radiation Chemistry, Faculty of Chemistry, Lodz University of Technology, Wroblewskiego 15, 93-590 Lodz, Poland. beata.brozek-pluska@p.lodz.pl. LA - eng GR - OPUS/NCN/ PT - Journal Article PT - Review DEP - 20190520 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - 0 (Cosmetics) RN - 0 (Water Pollutants, Chemical) SB - IM MH - *Biodegradation, Environmental MH - *Biomass MH - Cosmetics/*pharmacology MH - Microalgae/*drug effects/growth & development/metabolism MH - Water Pollutants, Chemical/*pharmacology PMC - PMC6567089 OTO - NOTNLM OT - biomass production OT - biomolecules OT - bioremediation OT - environmental pollution OT - industrial applications OT - microalgal cultivation OT - personal care products (PCPs) OT - pharmaceuticals (PHRs) OT - wastewaters COIS- The authors declare no conflict of interest. EDAT- 2019/05/30 06:00 MHDA- 2019/11/12 06:00 PMCR- 2019/05/01 CRDT- 2019/05/30 06:00 PHST- 2019/04/03 00:00 [received] PHST- 2019/05/07 00:00 [revised] PHST- 2019/05/09 00:00 [accepted] PHST- 2019/05/30 06:00 [entrez] PHST- 2019/05/30 06:00 [pubmed] PHST- 2019/11/12 06:00 [medline] PHST- 2019/05/01 00:00 [pmc-release] AID - ijms20102492 [pii] AID - ijms-20-02492 [pii] AID - 10.3390/ijms20102492 [doi] PST - epublish SO - Int J Mol Sci. 2019 May 20;20(10):2492. doi: 10.3390/ijms20102492.