PMID- 31139694
OWN - NLM
STAT- MEDLINE
DCOM- 20200323
LR  - 20200323
IS  - 2328-9503 (Print)
IS  - 2328-9503 (Electronic)
IS  - 2328-9503 (Linking)
VI  - 6
IP  - 5
DP  - 2019 May
TI  - Human leukocyte antigen associations in postural tachycardia syndrome.
PG  - 962-967
LID - 10.1002/acn3.766 [doi]
AB  - Associations between human leukocyte antigen (HLA) and postural orthostatic 
      tachycardia syndrome (POTS) have not been investigated. We included patients 
      diagnosed with POTS and showing orthostatic heart rate increases >/= 50 during 
      orthostatic vital sign measurement or experiencing syncope/near-syncope while 
      standing (prominent POTS; n = 17). DQB1*06:09 was present in seven (41%) 
      patients, a significantly higher percentage than in healthy Koreans (7%; odds 
      ratio [OR] 8.7, 95% confidence interval [CI] 3.1-24.3, corrected 
      P = 3.2 x 10(-4)) and epilepsy controls (8%; OR 7.9, 95% CI 2.7-23.5, corrected 
      P = 3.2 x 10(-4)). Six (35.3%) carried the 
      A*33:03-B*58:01-C*03:02-DRB1*13:02-DQB1*06:09 haplotype. The results signify an 
      autoimmune etiology in prominent POTS.
FAU - Shin, Yong-Won
AU  - Shin YW
AD  - Department of Neurology Laboratory for Neurotherapeutics Biomedical Research 
      Institute Seoul National University Hospital Seoul South Korea.
FAU - Moon, Jangsup
AU  - Moon J
AD  - Department of Neurology Laboratory for Neurotherapeutics Biomedical Research 
      Institute Seoul National University Hospital Seoul South Korea.
AD  - Department of Neurosurgery Seoul National University Hospital Seoul South Korea.
FAU - Kim, Tae-Joon
AU  - Kim TJ
AD  - Department of Neurology Laboratory for Neurotherapeutics Biomedical Research 
      Institute Seoul National University Hospital Seoul South Korea.
AD  - Department of Neurology Ajou University School of Medicine Suwon South Korea.
FAU - Kim, Do-Yong
AU  - Kim DY
AD  - Department of Neurology Laboratory for Neurotherapeutics Biomedical Research 
      Institute Seoul National University Hospital Seoul South Korea.
FAU - Chang, Hyeyeon
AU  - Chang H
AD  - Department of Neurology Laboratory for Neurotherapeutics Biomedical Research 
      Institute Seoul National University Hospital Seoul South Korea.
FAU - Jun, Jin-Sun
AU  - Jun JS
AD  - Department of Neurosurgery Seoul National University Hospital Seoul South Korea.
FAU - Lee, Soon-Tae
AU  - Lee ST
AD  - Department of Neurology Laboratory for Neurotherapeutics Biomedical Research 
      Institute Seoul National University Hospital Seoul South Korea.
FAU - Jung, Keun-Hwa
AU  - Jung KH
AUID- ORCID: 0000-0003-1433-8005
AD  - Department of Neurology Laboratory for Neurotherapeutics Biomedical Research 
      Institute Seoul National University Hospital Seoul South Korea.
FAU - Park, Kyung-Il
AU  - Park KI
AD  - Department of Neurology Seoul National University Hospital Healthcare System 
      Gangnam Center Seoul South Korea.
FAU - Jung, Ki-Young
AU  - Jung KY
AD  - Department of Neurology Laboratory for Neurotherapeutics Biomedical Research 
      Institute Seoul National University Hospital Seoul South Korea.
FAU - Kim, Manho
AU  - Kim M
AD  - Department of Neurology Laboratory for Neurotherapeutics Biomedical Research 
      Institute Seoul National University Hospital Seoul South Korea.
FAU - Lee, Sang Kun
AU  - Lee SK
AD  - Department of Neurology Laboratory for Neurotherapeutics Biomedical Research 
      Institute Seoul National University Hospital Seoul South Korea.
FAU - Chu, Kon
AU  - Chu K
AUID- ORCID: 0000-0001-5863-0302
AD  - Department of Neurology Laboratory for Neurotherapeutics Biomedical Research 
      Institute Seoul National University Hospital Seoul South Korea.
LA  - eng
PT  - Journal Article
DEP - 20190404
PL  - United States
TA  - Ann Clin Transl Neurol
JT  - Annals of clinical and translational neurology
JID - 101623278
RN  - 0 (HLA Antigens)
RN  - 0 (Receptor, Angiotensin, Type 1)
RN  - 0 (Receptors, Adrenergic)
MH  - Adolescent
MH  - Adult
MH  - Blood Pressure
MH  - Female
MH  - HLA Antigens/*physiology
MH  - Heart Rate
MH  - Humans
MH  - Male
MH  - Postural Orthostatic Tachycardia Syndrome/*genetics/*physiopathology
MH  - Receptor, Angiotensin, Type 1/genetics
MH  - Receptors, Adrenergic/genetics
MH  - Syncope
PMC - PMC6529927
COIS- The authors declare no conflict of interest.
EDAT- 2019/05/30 06:00
MHDA- 2019/05/30 06:01
PMCR- 2019/04/04
CRDT- 2019/05/30 06:00
PHST- 2018/12/07 00:00 [received]
PHST- 2019/02/28 00:00 [revised]
PHST- 2019/03/01 00:00 [accepted]
PHST- 2019/05/30 06:00 [entrez]
PHST- 2019/05/30 06:00 [pubmed]
PHST- 2019/05/30 06:01 [medline]
PHST- 2019/04/04 00:00 [pmc-release]
AID - ACN3766 [pii]
AID - 10.1002/acn3.766 [doi]
PST - epublish
SO  - Ann Clin Transl Neurol. 2019 Apr 4;6(5):962-967. doi: 10.1002/acn3.766. 
      eCollection 2019 May.