PMID- 31140540
OWN - NLM
STAT- MEDLINE
DCOM- 20200511
LR  - 20200511
IS  - 1680-0745 (Electronic)
IS  - 1015-9657 (Linking)
VI  - 30
IP  - 4
DP  - 2019 Jul/Aug 23
TI  - The effect of perindopril on echocardiographic parameters, NYHA functional class 
      and serum NT-proBNP values in patients with diastolic heart failure.
PG  - 222-227
LID - 10.5830/CVJA-2019-022 [doi]
AB  - INTRODUCTION: Growing evidence has demonstrated that diastolic heart failure 
      occurs in about half of heart failure (HF) patients. We investigated the effects 
      of perindopril on echocardiographic parameters, New York Heart Association (NYHA) 
      functional class and serum N-terminal pro B-type natriuretic peptide (NT-proBNP) 
      levels in patients with diastolic heart failure. METHODS: In total, 108 diastolic 
      heart failure patients aged >/= 50 years, who had diastolic dysfunction with an 
      ejection fraction >/= 50%, were enrolled and randomised to one of the two study 
      groups. Perindopril was initiated in the study group and the control group was 
      given standard therapy. Echocardiographic parameters, NT-proBNP levels and NYHA 
      classes were recorded. The patients were followed for 11 (three to 16) months. 
      Eighty-eight patients completed the study. RESULTS: Although diastolic parameters 
      were not changed, A' (septal) velocity (10.8 vs 9.9 cm/s) and Sm (septal) 
      velocity (8.5 vs 7.6 cm/s) were significantly increased in the perindopril 
      compared to the control group. A significant increase in A' (septal) velocity 
      (+0.61 vs -0.28 cm/s, p = 0.04) and a slight increase in Sm (septal) velocity 
      (+0.99 vs 0.36 cm/s, p = 0.054) were noted in the perindopril group. CONCLUSIONS: 
      Tissue Doppler septal late diastolic velocities and septal systolic myocardial 
      velocities increased in the perindopril group but NT-proBNP levels, and NYHA 
      class was not changed in this study population.
FAU - Yuksek, Umit
AU  - Yuksek U
AD  - Department of Cardiology, Near East University Hospital, Nicosia, Cyprus.
FAU - Cerit, Levent
AU  - Cerit L
AD  - Department of Cardiology, Near East University Hospital, Nicosia, Cyprus. Email: 
      drcerit@hotmail.com.
FAU - Eren, Nihan Kahya
AU  - Eren NK
AD  - Department of Cardiology, Izmir Ataturk Education and Research Hospital, Izmir, 
      Turkey.
FAU - Ergene, Oktay
AU  - Ergene O
AD  - Department of Cardiology, 9 Eylul University Hospital, Izmir, Turkey.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20190524
PL  - South Africa
TA  - Cardiovasc J Afr
JT  - Cardiovascular journal of Africa
JID - 101313864
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Biomarkers)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - Y5GMK36KGY (Perindopril)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiotensin-Converting Enzyme Inhibitors/adverse effects/*therapeutic use
MH  - Atrial Function, Left/*drug effects
MH  - Biomarkers/blood
MH  - *Echocardiography, Doppler
MH  - Female
MH  - Heart Failure, Diastolic/blood/diagnostic imaging/*drug therapy/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - Perindopril/adverse effects/*therapeutic use
MH  - Predictive Value of Tests
MH  - Time Factors
MH  - Treatment Outcome
MH  - Turkey
OTO - NOTNLM
OT  - NT-proBNP
OT  - diastolic heart failure
OT  - perindopril
OT  - transthoracic echocardiography
EDAT- 2019/05/30 06:00
MHDA- 2020/05/12 06:00
CRDT- 2019/05/30 06:00
PHST- 2018/11/09 00:00 [received]
PHST- 2019/04/21 00:00 [accepted]
PHST- 2019/05/30 06:00 [pubmed]
PHST- 2020/05/12 06:00 [medline]
PHST- 2019/05/30 06:00 [entrez]
AID - 10.5830/CVJA-2019-022 [doi]
PST - ppublish
SO  - Cardiovasc J Afr. 2019 Jul/Aug 23;30(4):222-227. doi: 10.5830/CVJA-2019-022. Epub 
      2019 May 24.