PMID- 31140629
OWN - NLM
STAT- MEDLINE
DCOM- 20200117
LR  - 20200117
IS  - 1098-2299 (Electronic)
IS  - 0272-4391 (Linking)
VI  - 80
IP  - 4
DP  - 2019 Jun
TI  - Folic acid functionalized nanoparticles as pharmaceutical carriers in drug 
      delivery systems.
PG  - 404-424
LID - 10.1002/ddr.21545 [doi]
AB  - Conventional chemotherapeutic approaches in cancer therapy such as surgery, 
      chemotherapy, and radiotherapy have several disadvantages due to their 
      nontargeted distributions in the whole body. On the other hand, nanoparticles 
      (NPs) based therapies are remarkably progressing to solve several limitations of 
      conventional drug delivery systems (DDSs) including nonspecific biodistribution 
      and targeting, poor water solubility, weak bioavailability and biodegradability, 
      low pharmacokinetic properties, and so forth. The enhanced permeability and 
      retention effect escape from P-glycoprotein trap in cancer cells as a passive 
      targeting mechanism, and active targeting strategies are also other most 
      important advantages of NPs in cancer diagnosis and therapy. Folic acid (FA) is 
      one of the biologic molecules which has been targeted overexpressed-folic acid 
      receptor (FR) on the surface of cancer cells. Therefore, conjugation of FA to NPs 
      most easily enhances the FR-mediated targeting delivery of therapeutic agents. 
      Here, the recent works in FA which have been decorated NPs-based DDSs are 
      discussed and cancer therapy potency of these NPs in clinical trials are 
      presented.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Narmani, Asghar
AU  - Narmani A
AUID- ORCID: 0000-0001-9199-188X
AD  - Department of Life Science Engineering, Faculty of New Sciences and Technologies, 
      University of Tehran, Tehran, Iran.
FAU - Rezvani, Melina
AU  - Rezvani M
AD  - Department of Biology, Faculty of Sciences, Payame Noor University, Tehran, Iran.
FAU - Farhood, Bagher
AU  - Farhood B
AD  - Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, 
      Kashan University of Medical Sciences, Kashan, Iran.
FAU - Darkhor, Parvaneh
AU  - Darkhor P
AD  - Department of Medical Physics, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
FAU - Mohammadnejad, Javad
AU  - Mohammadnejad J
AD  - Department of Life Science Engineering, Faculty of New Sciences and Technologies, 
      University of Tehran, Tehran, Iran.
FAU - Amini, Bahram
AU  - Amini B
AD  - Department of Biology, Science and Research Branch, Islamic Azad University, 
      Tehran, Iran.
FAU - Refahi, Soheila
AU  - Refahi S
AD  - Department of Medical Physics, Faculty of Medicine, Ardabil University of Medical 
      Sciences, Ardabil, Iran.
FAU - Abdi Goushbolagh, Nouraddin
AU  - Abdi Goushbolagh N
AD  - Department of Medical Physics, Faculty of Medicine, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190529
PL  - United States
TA  - Drug Dev Res
JT  - Drug development research
JID - 8204468
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Drug Carriers)
RN  - 935E97BOY8 (Folic Acid)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/*administration & dosage
MH  - Cell Line, Tumor
MH  - Drug Carriers/*chemistry
MH  - Drug Delivery Systems
MH  - Drug Evaluation, Preclinical
MH  - Folic Acid/*chemistry
MH  - Humans
MH  - Nanoparticles/*chemistry
MH  - Neoplasms/drug therapy/pathology
OTO - NOTNLM
OT  - cancer diagnosis and therapy
OT  - folic acid
OT  - nanoparticles
OT  - nanotechnology
OT  - targeted drug delivery
EDAT- 2019/05/30 06:00
MHDA- 2020/01/18 06:00
CRDT- 2019/05/30 06:00
PHST- 2019/01/04 00:00 [received]
PHST- 2019/03/02 00:00 [revised]
PHST- 2019/05/07 00:00 [accepted]
PHST- 2019/05/30 06:00 [pubmed]
PHST- 2020/01/18 06:00 [medline]
PHST- 2019/05/30 06:00 [entrez]
AID - 10.1002/ddr.21545 [doi]
PST - ppublish
SO  - Drug Dev Res. 2019 Jun;80(4):404-424. doi: 10.1002/ddr.21545. Epub 2019 May 29.