PMID- 31140742
OWN - NLM
STAT- MEDLINE
DCOM- 20200715
LR  - 20221207
IS  - 2324-9269 (Electronic)
IS  - 2324-9269 (Linking)
VI  - 7
IP  - 7
DP  - 2019 Jul
TI  - Assessment of the association between ACYP2 and laryngeal squamous cell carcinoma 
      risk in Chinese males.
PG  - e00731
LID - 10.1002/mgg3.731 [doi]
LID - e00731
AB  - BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent 
      malignant neoplasms of the upper respiratory tract. Studies have confirmed that 
      an unstable chromosome constitution promotes the progress of laryngeal 
      tumorigenesis, and ACYP2 has been confirmed as a telomere length-related gene. 
      However, to date, the association between ACYP2 polymorphisms and LSCC 
      susceptibility has not been investigated. METHODS: We performed this study to 
      explore the effect of 11 single-nucleotide polymorphisms (SNPs) in ACYP2 on LSCC 
      susceptibility in Chinese Han males. Unconditional logistic regression analysis 
      adjusted for age was used to calculate the odds ratios and 95% confidence 
      intervals. RESULTS: Based on allele and genotype models, our results showed that 
      rs1682111 variant was significantly associated with a decreased LSCC 
      susceptibility (p < 0.05). On the contrary, polymorphisms of rs10439478, 
      rs11125529, rs12615793, rs843711, rs11896604, and rs17045754 were significantly 
      associated with an increased LSCC risk (p < 0.05). The results of haplotype 
      analysis indicated that haplotypes "TTCTCG" and "TTCTAA" in block 1 and "TG" in 
      block 2 showed a risk factor for the development of LCSS (p = 0.009, p < 0.001, 
      and p = 0.001, respectively). The results of Genotype-Tissue Expression analysis 
      indicate that these significant SNPs were known to be associated with ACYP2 
      expression. CONCLUSION: Our data demonstrated that ACYP2 polymorphisms may exert 
      effects on LSCC susceptibility in Chinese Han males.
CI  - (c) 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley 
      Periodicals, Inc.
FAU - Zhao, Wenhui
AU  - Zhao W
AD  - Department of Anesthesiology, Shaanxi Provincial Cancer Hospital, Xi'an, China.
FAU - Niu, Fanglin
AU  - Niu F
AD  - Key Laboratory of Resource Biology and Biotechnology in Western China, Northwest 
      University, Ministry of Education, Xi'an, China.
FAU - Xie, Zhilan
AU  - Xie Z
AD  - Key Laboratory of Resource Biology and Biotechnology in Western China, Northwest 
      University, Ministry of Education, Xi'an, China.
FAU - Yan, Mengdan
AU  - Yan M
AD  - Key Laboratory of Resource Biology and Biotechnology in Western China, Northwest 
      University, Ministry of Education, Xi'an, China.
FAU - Li, Jingjie
AU  - Li J
AD  - Key Laboratory of Resource Biology and Biotechnology in Western China, Northwest 
      University, Ministry of Education, Xi'an, China.
FAU - Zhang, Yuan
AU  - Zhang Y
AD  - Key Laboratory of Resource Biology and Biotechnology in Western China, Northwest 
      University, Ministry of Education, Xi'an, China.
FAU - Chen, Jun
AU  - Chen J
AD  - Department of Anesthesiology, Shaanxi Provincial Cancer Hospital, Xi'an, China.
FAU - Liu, Qiufang
AU  - Liu Q
AD  - Department of Radiotherapy, Shaanxi Provincial Cancer Hospital Affiliated to 
      Medical College, Xi'an Jiaotong University, Xi'an, China.
FAU - Jin, Tianbo
AU  - Jin T
AUID- ORCID: 0000-0002-7491-3991
AD  - Key Laboratory of Resource Biology and Biotechnology in Western China, Northwest 
      University, Ministry of Education, Xi'an, China.
AD  - Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School 
      of Medicine, Xizang Minzu University, Xianyang, China.
LA  - eng
PT  - Journal Article
DEP - 20190529
PL  - United States
TA  - Mol Genet Genomic Med
JT  - Molecular genetics & genomic medicine
JID - 101603758
RN  - EC 3.6.- (Acid Anhydride Hydrolases)
RN  - EC 3.6.1.7 (ACYP2 protein, human)
SB  - IM
MH  - Acid Anhydride Hydrolases/*genetics/metabolism
MH  - Alleles
MH  - Asian People/genetics
MH  - Carcinoma, Squamous Cell/genetics
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Gene Frequency/genetics
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/metabolism
MH  - Male
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Risk Factors
PMC - PMC6625106
OTO - NOTNLM
OT  - ACYP2
OT  - gene expression
OT  - laryngeal squamous cell carcinoma (LSCC)
OT  - single-nucleotide polymorphisms (SNPs)
COIS- The authors declare no conflict of interest.
EDAT- 2019/05/30 06:00
MHDA- 2020/07/16 06:00
PMCR- 2019/05/29
CRDT- 2019/05/30 06:00
PHST- 2018/12/11 00:00 [received]
PHST- 2019/04/16 00:00 [revised]
PHST- 2019/04/22 00:00 [accepted]
PHST- 2019/05/30 06:00 [pubmed]
PHST- 2020/07/16 06:00 [medline]
PHST- 2019/05/30 06:00 [entrez]
PHST- 2019/05/29 00:00 [pmc-release]
AID - MGG3731 [pii]
AID - 10.1002/mgg3.731 [doi]
PST - ppublish
SO  - Mol Genet Genomic Med. 2019 Jul;7(7):e00731. doi: 10.1002/mgg3.731. Epub 2019 May 
      29.