PMID- 31141208
OWN - NLM
STAT- MEDLINE
DCOM- 20191111
LR  - 20200108
IS  - 1470-8744 (Electronic)
IS  - 0885-4513 (Linking)
VI  - 66
IP  - 4
DP  - 2019 Jul
TI  - Green synthesis and bactericidal activities of isotropic and anisotropic 
      spherical gold nanoparticles produced using Peganum harmala L leaf and seed 
      extracts.
PG  - 664-672
LID - 10.1002/bab.1782 [doi]
AB  - Shape, size, and homogeneity affect the biological activity of gold nanoparticles 
      (AuNPs) in nanomedicine and catalytic applications. Here we biosynthesized 
      monodispersed isotropic and polydispersed anisotropic spherical AuNPs from leaf 
      and seed extract broths of the medicinal plant Peganum harmala L. (Ph. L). 
      Synthesized AuNPs were characterized by ultraviolet-visible spectroscopy, 
      Fourier-transform infrared spectroscopy (FT-IRS), field-emission scanning 
      electron microscopy (FESEM), X-ray diffraction (XRD), energy-dispersive X-ray 
      spectroscopy (EDX), and transmission electron microscopy (TEM). The antimicrobial 
      activity of AuNPs against Gram-negative (Escherichia coli) and Gram-positive 
      (Staphylococcus aureus) human pathogens was also assessed. Leaf- and seed-derived 
      AuNPs had characteristic localized surface plasmon resonances of 530 and 578 nm, 
      respectively. TEM, FE-SEM, EDX, and XRD revealed the formation of elemental 
      face-centered cubic spherical monodispersed isotropic AuNPs of average size 43.44 
      nm and polydispersed anisotropic AuNPs of average size 52.04 nm from leaf and 
      seed extract broths, respectively. FT-IR revealed polyphenols and alcohols as 
      responsible for AuNP capping, reduction, and protection. Anisotropic AuNPs showed 
      no antibacterial activity, whereas isotropic AuNPs showed good inhibition of both 
      E. coli and S. aureus. This represents a simple and ecofriendly protocol for the 
      green synthesis of monodispersed isotropic spherical AuNPs, which may have value 
      in a variety of applications.
CI  - (c) 2019 International Union of Biochemistry and Molecular Biology, Inc.
FAU - Moustafa, Nagy E
AU  - Moustafa NE
AUID- ORCID: 0000-0003-1104-6445
AD  - Department of Chemistry, Faculty of Science and Arts in Mukwah, Albaha 
      University, 65931, Bidah Valley, Saudi Arabia.
FAU - Alomari, Abdulaziz Ali
AU  - Alomari AA
AD  - Department of Chemistry, Faculty of Science and Arts in Mukwah, Albaha 
      University, 65931, Bidah Valley, Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20190605
PL  - United States
TA  - Biotechnol Appl Biochem
JT  - Biotechnology and applied biochemistry
JID - 8609465
RN  - 0 (Plant Extracts)
RN  - 7440-57-5 (Gold)
SB  - IM
MH  - Escherichia coli/chemistry/*metabolism
MH  - Gold/chemistry/*metabolism
MH  - *Green Chemistry Technology
MH  - Humans
MH  - Metal Nanoparticles/*chemistry
MH  - Peganum/*chemistry/metabolism
MH  - Plant Extracts/chemistry/metabolism
MH  - Plant Leaves/*chemistry/metabolism
MH  - Seeds/*chemistry/metabolism
MH  - Staphylococcus aureus/chemistry/*metabolism
MH  - Surface Plasmon Resonance
OTO - NOTNLM
OT  - Peganum harmala L
OT  - anisotropic
OT  - antibacterial
OT  - gold nanoparticles
OT  - isotopic
EDAT- 2019/05/30 06:00
MHDA- 2019/11/12 06:00
CRDT- 2019/05/30 06:00
PHST- 2019/03/19 00:00 [received]
PHST- 2019/05/28 00:00 [accepted]
PHST- 2019/05/30 06:00 [pubmed]
PHST- 2019/11/12 06:00 [medline]
PHST- 2019/05/30 06:00 [entrez]
AID - 10.1002/bab.1782 [doi]
PST - ppublish
SO  - Biotechnol Appl Biochem. 2019 Jul;66(4):664-672. doi: 10.1002/bab.1782. Epub 2019 
      Jun 5.