PMID- 31141592 OWN - NLM STAT- MEDLINE DCOM- 20211208 LR - 20211214 IS - 1528-8951 (Electronic) IS - 0148-0731 (Print) IS - 0148-0731 (Linking) VI - 142 IP - 2 DP - 2020 Feb 1 TI - Open-Source Routines for Building Personalized Left Ventricular Models From Cardiac Magnetic Resonance Imaging Data. PG - 0245041-6 LID - 024504 [pii] LID - 10.1115/1.4043876 [doi] AB - Creating patient-specific models of the heart is a promising approach for predicting outcomes in response to congenital malformations, injury, or disease, as well as an important tool for developing and customizing therapies. However, integrating multimodal imaging data to construct patient-specific models is a nontrivial task. Here, we propose an approach that employs a prolate spheroidal coordinate system to interpolate information from multiple imaging datasets and map those data onto a single geometric model of the left ventricle (LV). We demonstrate the mapping of the location and transmural extent of postinfarction scar segmented from late gadolinium enhancement (LGE) magnetic resonance imaging (MRI), as well as mechanical activation calculated from displacement encoding with stimulated echoes (DENSE) MRI. As a supplement to this paper, we provide MATLAB and Python versions of the routines employed here for download from SimTK. CI - Copyright (c) 2020 by ASME. FAU - Phung, Thien-Khoi N AU - Phung TN AD - Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908. FAU - Waters, Christopher D AU - Waters CD AD - Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908. FAU - Holmes, Jeffrey W AU - Holmes JW AD - Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908; Department of Medicine, University of Virginia, Charlottesville, VA 22908; Robert M. Berne Cardiovascular Center, University of Virginia, 415 Lane Road, Charlottesville, VA 22908. LA - eng SI - CRiS/NCT03398369 GR - U01 HL127654/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PL - United States TA - J Biomech Eng JT - Journal of biomechanical engineering JID - 7909584 RN - 0 (Contrast Media) RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Cicatrix MH - *Contrast Media MH - Gadolinium MH - *Heart Ventricles MH - Humans MH - Imaging, Three-Dimensional MH - Magnetic Resonance Imaging MH - Middle Aged PMC - PMC7104752 OTO - NOTNLM OT - cardiac biomechanics OT - data fusion OT - finite element models OT - image registration OT - patient-specific modeling EDAT- 2019/05/30 06:00 MHDA- 2021/12/15 06:00 PMCR- 2021/02/01 CRDT- 2019/05/30 06:00 PHST- 2018/12/21 00:00 [received] PHST- 2019/05/30 06:00 [pubmed] PHST- 2021/12/15 06:00 [medline] PHST- 2019/05/30 06:00 [entrez] PHST- 2021/02/01 00:00 [pmc-release] AID - 2735311 [pii] AID - BIO-18-1548 [pii] AID - 10.1115/1.4043876 [doi] PST - ppublish SO - J Biomech Eng. 2020 Feb 1;142(2):0245041-6. doi: 10.1115/1.4043876.