PMID- 31142131
OWN - NLM
STAT- MEDLINE
DCOM- 20200117
LR  - 20200117
IS  - 1477-0903 (Electronic)
IS  - 0960-3271 (Linking)
VI  - 38
IP  - 9
DP  - 2019 Sep
TI  - Caffeic acid abrogates 1,3-dichloro-2-propanol-induced hepatotoxicity by 
      upregulating nuclear erythroid-related factor 2 and downregulating nuclear 
      factor-kappa B.
PG  - 1092-1101
LID - 10.1177/0960327119851257 [doi]
AB  - 1,3-dichloro-2-propanol is a food-borne contaminant reported to cause liver 
      injury. In this study, we evaluated the protective influence of caffeic acid on 
      1,3-dichloro-2-propanol-induced hepatotoxicity in rats. Rats were randomized into 
      five groups (A-E). Rats received distilled water or caffeic acid (10 or 20 mg/kg 
      body weight) for 7 days. In addition, rats were challenged with 
      1,3-dichloro-2-propanol on day 7. Caffeic acid prevented 
      1,3-dichloro-2-propanol-mediated alterations in alkaline phosphatase, alanine and 
      aspartate aminotransferases, albumin and total bilirubin in the serum of rats. 
      Furthermore, caffeic acid lowered superoxide ion, hydrogen peroxide and 
      cytochrome P2E1 while increasing the activities of superoxide dismutase, catalase 
      and glutathione S-transferase in the liver of 1,3-dichloro-2-propanol-treated 
      rats. Caffeic acid raised the levels of nuclear erythroid-related factor 2 
      (Nrf-2), protein kinase A and phosphoinositide 3-kinase. Caffeic acid 
      pretreatment annulled 1,3-dichloro-2-propanol-mediated alterations in the 
      oxidative stress biomarkers; caspase-3, glutathione, malondialdehyde, protein 
      carbonyl and fragmented DNA, in the liver of rats. Contrastingly, caffeic acid 
      lowered 1,3-dichloro-2-propanol-mediated increase in the levels of nuclear 
      factor-kappa B (NF-kappaB), tumour necrosis factor-alpha, interleukin-1beta (IL-1beta) and 
      IL-6. In addition, caffeic acid preserved the morphological features of 
      1,3-dichloro-2-propanol-treated rats. Results from this study revealed that 
      caffeic acid protects against 1,3-dichloro-2-propanol-induced hepatotoxicity by 
      enhancing the cytoprotective enzymes through Nrf-2 while lowering inflammation 
      through NF-kappaB.
FAU - Ajiboye, T O
AU  - Ajiboye TO
AUID- ORCID: 0000-0003-2392-169X
AD  - Antioxidants, Redox Biology and Toxicology Research Laboratory, Department of 
      Medical Biochemistry, College of Health Sciences, Nile University of Nigeria, 
      FCT-Abuja, Nigeria.
FAU - Ajala-Lawal, R A
AU  - Ajala-Lawal RA
AD  - Antioxidants, Redox Biology and Toxicology Research Laboratory, Department of 
      Medical Biochemistry, College of Health Sciences, Nile University of Nigeria, 
      FCT-Abuja, Nigeria.
FAU - Adeyiga, A B
AU  - Adeyiga AB
AD  - Antioxidants, Redox Biology and Toxicology Research Laboratory, Department of 
      Medical Biochemistry, College of Health Sciences, Nile University of Nigeria, 
      FCT-Abuja, Nigeria.
LA  - eng
PT  - Journal Article
DEP - 20190529
PL  - England
TA  - Hum Exp Toxicol
JT  - Human & experimental toxicology
JID - 9004560
RN  - 0 (Caffeic Acids)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (NF-kappa B)
RN  - 0 (Nfe2l2 protein, rat)
RN  - 0 (Protective Agents)
RN  - 0F4P2VQC07 (1,3-dichloro-2-propanol)
RN  - 96-24-2 (alpha-Chlorohydrin)
RN  - U2S3A33KVM (caffeic acid)
SB  - IM
MH  - Animals
MH  - Caffeic Acids/pharmacology/*therapeutic use
MH  - Chemical and Drug Induced Liver Injury/*drug therapy/metabolism/pathology
MH  - Down-Regulation/drug effects
MH  - Liver/drug effects/metabolism/pathology
MH  - NF-E2-Related Factor 2/metabolism
MH  - NF-kappa B/metabolism
MH  - Protective Agents/pharmacology/*therapeutic use
MH  - Rats
MH  - alpha-Chlorohydrin/*analogs & derivatives/toxicity
OTO - NOTNLM
OT  - Phenolic acids
OT  - apoptosis
OT  - inflammation
OT  - oxidative stress
OT  - reactive oxygen species
EDAT- 2019/05/31 06:00
MHDA- 2020/01/18 06:00
CRDT- 2019/05/31 06:00
PHST- 2019/05/31 06:00 [pubmed]
PHST- 2020/01/18 06:00 [medline]
PHST- 2019/05/31 06:00 [entrez]
AID - 10.1177/0960327119851257 [doi]
PST - ppublish
SO  - Hum Exp Toxicol. 2019 Sep;38(9):1092-1101. doi: 10.1177/0960327119851257. Epub 
      2019 May 29.