PMID- 31143990
OWN - NLM
STAT- MEDLINE
DCOM- 20200127
LR  - 20210109
IS  - 1433-2965 (Electronic)
IS  - 0937-941X (Linking)
VI  - 30
IP  - 8
DP  - 2019 Aug
TI  - Dietary inflammatory index(R) and cortical bone outcomes in healthy adolescent 
      children.
PG  - 1645-1654
LID - 10.1007/s00198-019-04946-3 [doi]
AB  - Diet is thought to modulate inflammation. This study shows no relationships 
      between the dietary inflammatory index (DII) and biomarkers of inflammation or 
      bone after adjusting for covariates. Monocyte chemoattractant protein-1 was 
      inversely associated with peripheral tibia cortical thickness and prospective 
      childhood studies should be conducted to better understand this relationship and 
      to determine if there are long-term consequences in adulthood. INTRODUCTION: 
      Examine the relationships between the DII-scores and bone and biomarkers of 
      inflammation in 290 adolescents, ages 9-13 years. METHODS: DII-scores were 
      calculated from 3-day diet records and categorized into tertiles, low (< - 1.34), 
      medium (- 1.34 to 1.41), and high (> 1.41) inflammation. Radius and tibia bone 
      were assessed via peripheral quantitative computed tomography (Stratec XCT 2000) 
      at the 66% site relative to the distal growth plate. Fasting serum was measured 
      for tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), vascular 
      endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1). 
      The relationships between DII-scores and bone and biomarkers of inflammation were 
      assessed using bivariate and partial correlations adjusting for sexual 
      maturation, sex, race, muscle cross-sectional area, and height. ANOVA/ANCOVA 
      models were used to compare DII-tertiles with dependent variables. RESULTS: 
      DII-scores were negatively associated with tibia trabecular area (TtAr; 
      r = - .141, P = .019), periosteal perimeter (PsPM; r = - .145, P = .016), 
      endosteal perimeter (r = - .145, P = .016), strength strain index (SSI; 
      r = - .129, P = .032), and radius TtAr (r = - .140, P = .020), PsPM (r = -.138, 
      P = .027) and SSI (r = -.131, P = .036) but nullified when adjusting for 
      covariates. Tibia PsPM was higher in the low DII group compared to the medium 
      (P = .050) and high (P = .046) groups but nullified after controlling for 
      covariates. DII-scores were not associated with TNF-alpha, VEGF, or IL-6, but were 
      associated with MCP-1 only in the unadjusted model (r = .125, P = .042). In the 
      adjusted model, MCP-1 was inversely associated with tibia cortical thickness 
      (r = -.150 P = .030). CONCLUSION: The DII-scores were not related to biomarkers 
      of inflammation or bone; however, the biomarker of inflammation, MCP-1 was 
      negatively associated with tibia CtTh. Future prospective pediatric studies 
      should be conducted to better understand this relationship and determine if there 
      are long-term implications in adulthood.
FAU - Coheley, L M
AU  - Coheley LM
AD  - Department of Foods and Nutrition, The University of Georgia, 279 Dawson Hall, 
      305 Sanford Drive, Athens, GA, USA.
FAU - Shivappa, N
AU  - Shivappa N
AD  - The Cancer Prevention and Control Program, Arnold School of Public Health, 915 
      Green Street, Columbia, SC, USA.
FAU - Hebert, J R
AU  - Hebert JR
AD  - The Cancer Prevention and Control Program, Arnold School of Public Health, 915 
      Green Street, Columbia, SC, USA.
FAU - Lewis, R D
AU  - Lewis RD
AD  - Department of Foods and Nutrition, The University of Georgia, 279 Dawson Hall, 
      305 Sanford Drive, Athens, GA, USA. rdlewis@uga.edu.
LA  - eng
GR  - RO1HD057126/National Institutes of Health/
GR  - GEO00797; GEO00798/National Institute of Food and Agriculture/
PT  - Journal Article
DEP - 20190529
PL  - England
TA  - Osteoporos Int
JT  - Osteoporosis international : a journal established as result of cooperation 
      between the European Foundation for Osteoporosis and the National Osteoporosis 
      Foundation of the USA
JID - 9100105
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Adolescent
MH  - Adolescent Nutritional Physiological Phenomena/*physiology
MH  - Anthropometry/methods
MH  - Biomarkers/blood
MH  - Body Composition/physiology
MH  - Bone Density/physiology
MH  - Chemokine CCL2/blood
MH  - Child
MH  - Cortical Bone/pathology/*physiopathology
MH  - Cross-Sectional Studies
MH  - *Diet
MH  - Female
MH  - Humans
MH  - Inflammation/blood/*physiopathology
MH  - Inflammation Mediators/analysis
MH  - Male
MH  - Nutrition Assessment
MH  - Tibia/pathology/physiopathology
MH  - Tomography, X-Ray Computed/methods
OTO - NOTNLM
OT  - Adolescents
OT  - DII
OT  - Diet
OT  - Inflammation
OT  - pQCT
EDAT- 2019/05/31 06:00
MHDA- 2020/01/28 06:00
CRDT- 2019/05/31 06:00
PHST- 2018/10/10 00:00 [received]
PHST- 2019/03/18 00:00 [accepted]
PHST- 2019/05/31 06:00 [pubmed]
PHST- 2020/01/28 06:00 [medline]
PHST- 2019/05/31 06:00 [entrez]
AID - 10.1007/s00198-019-04946-3 [pii]
AID - 10.1007/s00198-019-04946-3 [doi]
PST - ppublish
SO  - Osteoporos Int. 2019 Aug;30(8):1645-1654. doi: 10.1007/s00198-019-04946-3. Epub 
      2019 May 29.