PMID- 31144257 OWN - NLM STAT- MEDLINE DCOM- 20191203 LR - 20191203 IS - 1875-8312 (Electronic) IS - 1569-5794 (Linking) VI - 35 IP - 10 DP - 2019 Oct TI - 3-Dimensional regional and global strain abnormalities in hypertrophic cardiomyopathy. PG - 1913-1924 LID - 10.1007/s10554-019-01631-8 [doi] AB - Hypertrophic cardiomyopathy (HCM) is characterized by myocardial disarray, hypertrophy, and fibrosis. Reduced global longitudinal strain and presence of late gadolinium enhancement (LGE) by cardiac magnetic resonance imaging (CMR) have been associated with an adverse prognosis. This study evaluated 3D principal and conventional strain characteristics of non-enhanced myocardium in patients with HCM. 3D principal and conventional strain analysis was conducted in 51 HCM patients and 38 healthy controls. Principal strain was reduced within the non-enhanced myocardium of HCM as compared with controls (maximum principal: 51.5 +/- 23.7 vs. 75.1 +/- 21.4%, P < 0.0001; minimum principal: - 18.4 +/- 4.0 vs. - 20.1 +/- 2.9%, P < 0.05). Principal strain within the non-enhanced myocardium was incrementally reduced in HCM patients with extensive global LGE ( >/= 15%) (maximum principal: 41.6 +/- 17.5 vs. 56.9 +/- 25.9%, P < 0.05; minimum principal: - 16.9 +/- 3.9 vs. - 19.1 +/- 4.0%, P = 0.1), as was longitudinal ( - 10.5 +/- 2.6 vs. - 12.7 +/- 2.6%, P < 0.05) and circumferential strain ( - 11.0 +/- 2.7 vs. - 14.0 +/- 2.9%, P < 0.01). Principal strain within non-enhanced myocardium was significantly correlated with indexed LV mass (P < 0.0001), maximum (P = 0.0008), and mean wall thickness (P < 0.0001), but not LGE (P = 0.0841). In adjusted analysis, all strain measures within non-enhanced myocardium were independently associated with indexed LV mass (maximum principal: P = 0.0003; minimum principal: P = 0.0039; longitudinal: P = 0.0015; circumferential: P = 0.0002; radial: P = 0.0023). 3D principal strain of non-enhanced myocardium was significantly reduced in HCM patients as compared with controls, and was incrementally reduced among patients with more extensive global LGE. Comprehensive strain assessment may be considered in routine CMR assessment of HCM patients. FAU - Satriano, Alessandro AU - Satriano A AD - Division of Cardiology, Department of Cardiac Sciences, Stephenson Cardiac Imaging Centre, University of Calgary, Calgary, Canada. FAU - Heydari, Bobak AU - Heydari B AUID- ORCID: 0000-0002-5231-0866 AD - Division of Cardiology, Department of Cardiac Sciences, Stephenson Cardiac Imaging Centre, University of Calgary, Calgary, Canada. bobby.heydari@ucalgary.ca. AD - Foothills Medical Centre, Suite 0700, 1403 29th St NW, Calgary, AB, T2N 2T9, Canada. bobby.heydari@ucalgary.ca. FAU - Guron, Namrata AU - Guron N AD - Division of Cardiology, Department of Cardiac Sciences, Stephenson Cardiac Imaging Centre, University of Calgary, Calgary, Canada. FAU - Fenwick, Kate AU - Fenwick K AD - Division of Cardiology, Department of Cardiac Sciences, Stephenson Cardiac Imaging Centre, University of Calgary, Calgary, Canada. FAU - Cheung, Matthew AU - Cheung M AD - Division of Cardiology, Department of Cardiac Sciences, Stephenson Cardiac Imaging Centre, University of Calgary, Calgary, Canada. FAU - Mikami, Yoko AU - Mikami Y AD - Division of Cardiology, Department of Cardiac Sciences, Stephenson Cardiac Imaging Centre, University of Calgary, Calgary, Canada. FAU - Merchant, Naeem AU - Merchant N AD - Division of Cardiology, Department of Cardiac Sciences, Stephenson Cardiac Imaging Centre, University of Calgary, Calgary, Canada. AD - Department of Diagnostic Imaging, University of Calgary, Calgary, Canada. FAU - Lydell, Carmen P AU - Lydell CP AD - Division of Cardiology, Department of Cardiac Sciences, Stephenson Cardiac Imaging Centre, University of Calgary, Calgary, Canada. AD - Department of Diagnostic Imaging, University of Calgary, Calgary, Canada. FAU - Howarth, Andrew G AU - Howarth AG AD - Division of Cardiology, Department of Cardiac Sciences, Stephenson Cardiac Imaging Centre, University of Calgary, Calgary, Canada. FAU - Fine, Nowell M AU - Fine NM AD - Division of Cardiology, Department of Cardiac Sciences, Stephenson Cardiac Imaging Centre, University of Calgary, Calgary, Canada. FAU - White, James A AU - White JA AD - Division of Cardiology, Department of Cardiac Sciences, Stephenson Cardiac Imaging Centre, University of Calgary, Calgary, Canada. LA - eng GR - Shareholder/Cohesic Inc./ GR - Consulting Fees/Amgen Canada (CA)/ GR - Consulting Fees/Novartis Pharmaceuticals Canada (CA)/ GR - Consulting Fees/Pfizer/ GR - Research Support/Circle Cardiovascular Inc./ PT - Journal Article DEP - 20190529 PL - United States TA - Int J Cardiovasc Imaging JT - The international journal of cardiovascular imaging JID - 100969716 RN - 0 (Contrast Media) RN - 0 (Organometallic Compounds) RN - 1BJ477IO2L (gadobutrol) SB - IM MH - Adult MH - Aged MH - Biomechanical Phenomena MH - Cardiomyopathy, Hypertrophic/*diagnostic imaging/physiopathology MH - Case-Control Studies MH - Contrast Media/administration & dosage MH - Cross-Sectional Studies MH - Female MH - Humans MH - Image Interpretation, Computer-Assisted MH - Imaging, Three-Dimensional/*methods MH - Magnetic Resonance Imaging, Cine/*methods MH - Male MH - Middle Aged MH - *Myocardial Contraction MH - Organometallic Compounds/administration & dosage MH - Predictive Value of Tests OTO - NOTNLM OT - Cardiomyopathy OT - Contractile function OT - Hypertrophy OT - Magnetic resonance imaging EDAT- 2019/05/31 06:00 MHDA- 2019/12/04 06:00 CRDT- 2019/05/31 06:00 PHST- 2018/10/12 00:00 [received] PHST- 2019/05/18 00:00 [accepted] PHST- 2019/05/31 06:00 [pubmed] PHST- 2019/12/04 06:00 [medline] PHST- 2019/05/31 06:00 [entrez] AID - 10.1007/s10554-019-01631-8 [pii] AID - 10.1007/s10554-019-01631-8 [doi] PST - ppublish SO - Int J Cardiovasc Imaging. 2019 Oct;35(10):1913-1924. doi: 10.1007/s10554-019-01631-8. Epub 2019 May 29.