PMID- 31144630
OWN - NLM
STAT- MEDLINE
DCOM- 20201002
LR  - 20201002
IS  - 1558-254X (Electronic)
IS  - 0278-0062 (Linking)
VI  - 39
IP  - 1
DP  - 2020 Jan
TI  - Framework for Photon Counting Quantitative Material Decomposition.
PG  - 35-47
LID - 10.1109/TMI.2019.2914370 [doi]
AB  - In this paper, the accuracy of material decomposition (MD) using an energy 
      discriminating photon counting detector was studied. An MD framework was 
      established and validated using calcium hydroxyapatite (CaHA) inserts of known 
      densities (50 mg/cm(3), 100 mg/cm(3), 250 mg/cm(3), 400 mg/cm(3)), and diameters 
      (1.2, 3.0, and 5.0 mm). These inserts were placed in a cardiac rod phantom that 
      mimics a tissue equivalent heart and measured using an experimental photon 
      counting detector cone beam computed tomography (PCD-CBCT) setup. The 
      quantitative coronary calcium scores (density, mass, and volume) obtained from 
      the MD framework were compared with the nominal values. In addition, three 
      different calibration techniques, signal-to-equivalent thickness calibration 
      (STC), polynomial correction (PC), and projected equivalent thickness calibration 
      (PETC) were compared to investigate the effect of the calibration method on the 
      quantitative values. The obtained MD estimates agreed well with the nominal 
      values for density (mass) with mean absolute percent errors (MAPEs) 8 +/- 11% (9 +/- 
      15%) and 4 +/- 6% (9 +/- 14%) for STC and PETC calibration methods, respectively. PC 
      displayed large MAPEs for density (27 +/- 9%), and mass (25 +/- 12%). Volume 
      estimation resulted in large deviations between true and measured values with 
      notable MAPEs for STC (40 +/- 90%), PC (40 +/- 80%), and PETC (40 +/- 90%). The 
      framework demonstrated the feasibility of quantitative CaHA mass and density 
      scoring using PCD-CBCT.
FAU - Juntunen, Mikael A K
AU  - Juntunen MAK
FAU - Inkinen, Satu I
AU  - Inkinen SI
FAU - Ketola, Juuso H
AU  - Ketola JH
FAU - Kotiaho, Antti
AU  - Kotiaho A
FAU - Kauppinen, Matti
AU  - Kauppinen M
FAU - Winkler, Alexander
AU  - Winkler A
FAU - Nieminen, Miika T
AU  - Nieminen MT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190527
PL  - United States
TA  - IEEE Trans Med Imaging
JT  - IEEE transactions on medical imaging
JID - 8310780
RN  - 0 (Cadmium Compounds)
RN  - 91D9GV0Z28 (Durapatite)
RN  - NQA0O090ZJ (Tellurium)
RN  - STG188WO13 (cadmium telluride)
SB  - IM
MH  - Algorithms
MH  - Cadmium Compounds/chemistry
MH  - Calibration
MH  - Cone-Beam Computed Tomography/*methods
MH  - Durapatite/chemistry
MH  - Humans
MH  - Image Processing, Computer-Assisted/*methods
MH  - *Models, Cardiovascular
MH  - *Phantoms, Imaging
MH  - Photons
MH  - Tellurium/chemistry
EDAT- 2019/05/31 06:00
MHDA- 2020/10/03 06:00
CRDT- 2019/05/31 06:00
PHST- 2019/05/31 06:00 [pubmed]
PHST- 2020/10/03 06:00 [medline]
PHST- 2019/05/31 06:00 [entrez]
AID - 10.1109/TMI.2019.2914370 [doi]
PST - ppublish
SO  - IEEE Trans Med Imaging. 2020 Jan;39(1):35-47. doi: 10.1109/TMI.2019.2914370. Epub 
      2019 May 27.