PMID- 31145284
OWN - NLM
STAT- MEDLINE
DCOM- 20190606
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 98
IP  - 22
DP  - 2019 May
TI  - A diagnostic challenge of seromucinous borderline tumor: A case report.
PG  - e15707
LID - 10.1097/MD.0000000000015707 [doi]
LID - e15707
AB  - INTRODUCTION: Magnetic resonance (MR) relaxometry provides a noninvasive 
      predictive tool to discriminate between benign ovarian endometrioma (OE) and 
      endometriosis-associated ovarian cancer (EAOC). Transverse relaxation rate R2 
      value was determined using a single-voxel, multi-echo MR sequence (HISTO) by a 
      3T-MR system. R2 with cutoff value of 12.1 s was established to discriminate 
      between benign and malignant tumors. PATIENT CONCERNS: We present a case of a 
      39-year-old woman who was initially thought to be malignant transformation of 
      endometriosis by diagnostic MR imaging of the vascularized solid components. 
      DIAGNOSIS: A R2 value of 42.62 s on MR relaxometry demonstrated that this case is 
      non-malignant. INTERVENTIONS: To confirm the diagnose, left salpingo-oophorectomy 
      by laparoscopic surgery was performed. OUTCOMES: Histopathological results 
      revealed seromucinous borderline tumor (SMBT). Our experience suggests that 
      preoperative MR relaxometry may be useful for discriminating "borderline (SMBT)" 
      from "malignancy (EAOC)." Furthermore, immunohistochemical studies of this case 
      demonstrated ovarian SMBT cells were positive for estrogen receptor, progesterone 
      receptor, and hepatocyte nuclear factor-1beta. A similar expression pattern was 
      also observed in patients with benign OE. LESSONS: In many respects, SMBT 
      characteristics differ from those of EAOC but resemble those of benign OE. MR 
      relaxometry unveils a new clinical approach as an adjunctive modality for 
      discriminating SMBT from EAOC.
FAU - Liu, Tingting
AU  - Liu T
AD  - Department of Obstetrics and Gynecology.
FAU - Sumida, Daichi
AU  - Sumida D
AD  - Department of Obstetrics and Gynecology.
FAU - Wada, Takuya
AU  - Wada T
AD  - Department of Obstetrics and Gynecology.
FAU - Maehana, Tomoka
AU  - Maehana T
AD  - Department of Obstetrics and Gynecology.
FAU - Yamawaki, Aika
AU  - Yamawaki A
AD  - Department of Obstetrics and Gynecology.
FAU - Sugimoto, Sumire
AU  - Sugimoto S
AD  - Department of Diagnostic Pathology, Nara Medical University, Kashihara City, 
      Nara, Japan.
FAU - Kawahara, Naoki
AU  - Kawahara N
AD  - Department of Obstetrics and Gynecology.
FAU - Yoshimoto, Chiharu
AU  - Yoshimoto C
AD  - Department of Obstetrics and Gynecology.
FAU - Kobayashi, Hiroshi
AU  - Kobayashi H
AD  - Department of Obstetrics and Gynecology.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Adult
MH  - Diagnosis, Differential
MH  - Endometrial Neoplasms/*diagnostic imaging
MH  - Endometriosis/complications/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Spectroscopy/methods/*statistics & numerical data
MH  - Neoplasms, Cystic, Mucinous, and Serous/*diagnostic imaging/etiology
MH  - Ovarian Neoplasms/*diagnostic imaging/etiology
MH  - Ovary/diagnostic imaging/pathology
MH  - Reference Values
MH  - Salpingo-oophorectomy
PMC - PMC6709009
COIS- The authors declared no potential conflicts of interest with respect to the 
      research, authorship, and publication of this article.
EDAT- 2019/05/31 06:00
MHDA- 2019/06/07 06:00
PMCR- 2019/05/31
CRDT- 2019/05/31 06:00
PHST- 2019/05/31 06:00 [entrez]
PHST- 2019/05/31 06:00 [pubmed]
PHST- 2019/06/07 06:00 [medline]
PHST- 2019/05/31 00:00 [pmc-release]
AID - 00005792-201905310-00014 [pii]
AID - MD-D-18-09283 [pii]
AID - 10.1097/MD.0000000000015707 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2019 May;98(22):e15707. doi: 10.1097/MD.0000000000015707.