PMID- 31147877
OWN - NLM
STAT- MEDLINE
DCOM- 20190826
LR  - 20190826
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 1147
DP  - 2019
TI  - Pericytes in Alzheimer's Disease: Novel Clues to Cerebral Amyloid Angiopathy 
      Pathogenesis.
PG  - 147-166
LID - 10.1007/978-3-030-16908-4_7 [doi]
AB  - Pericytes in the central nervous system attract growing attention of 
      neurobiologists because of obvious opportunities to use them as target cells in 
      numerous brain diseases. Functional activity of pericytes includes control of 
      integrity of the endothelial cell layer, regeneration of vascular cells, and 
      regulation of microcirculation. Pericytes are well integrated in the so-called 
      neurovascular unit (NVU) serving as a platform for effective communications of 
      neurons, astrocytes, endothelial cells, and pericytes. Contribution of pericytes 
      to the establishment and maintaining the structural and functional integrity of 
      blood-brain barrier is confirmed in numerous experimental and clinical studies. 
      The review covers current understandings on the role of pericytes in molecular 
      pathogenesis of NVU/BBB dysfunction in Alzheimer's disease with the special focus 
      on the development of cerebral amyloid angiopathy, deregulation of cerebral 
      angiogenesis, and progression of BBB breakdown seen in Alzheimer's type 
      neurodegeneration.
FAU - Salmina, Alla B
AU  - Salmina AB
AD  - Department of Biochemistry, Medical, Pharmaceutical & Toxicological Chemistry, 
      Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, 
      Krasnoyarsk, Russia. allasalmina@mail.ru.
AD  - Research Institute of Molecular Medicine & Pathobiochemistry, Krasnoyarsk State 
      Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia. 
      allasalmina@mail.ru.
FAU - Komleva, Yulia K
AU  - Komleva YK
AD  - Department of Biochemistry, Medical, Pharmaceutical & Toxicological Chemistry, 
      Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, 
      Krasnoyarsk, Russia.
AD  - Research Institute of Molecular Medicine & Pathobiochemistry, Krasnoyarsk State 
      Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia.
FAU - Lopatina, Olga L
AU  - Lopatina OL
AD  - Department of Biochemistry, Medical, Pharmaceutical & Toxicological Chemistry, 
      Krasnoyarsk State Medical University named after Prof. V.F. Voino-Yasenetsky, 
      Krasnoyarsk, Russia.
AD  - Research Institute of Molecular Medicine & Pathobiochemistry, Krasnoyarsk State 
      Medical University named after Prof. V.F. Voino-Yasenetsky, Krasnoyarsk, Russia.
FAU - Birbrair, Alexander
AU  - Birbrair A
AD  - Department of Radiology, Columbia University Medical Center, New York, NY, USA.
AD  - Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, 
      Brazil.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
MH  - *Alzheimer Disease
MH  - Astrocytes
MH  - Blood-Brain Barrier
MH  - Brain
MH  - *Cerebral Amyloid Angiopathy
MH  - Humans
MH  - *Pericytes
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Amyloid angiopathy
OT  - Blood-brain barrier
OT  - Cerebral angiogenesis
OT  - Pericyte
EDAT- 2019/05/31 06:00
MHDA- 2019/08/27 06:00
CRDT- 2019/06/01 06:00
PHST- 2019/06/01 06:00 [entrez]
PHST- 2019/05/31 06:00 [pubmed]
PHST- 2019/08/27 06:00 [medline]
AID - 10.1007/978-3-030-16908-4_7 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2019;1147:147-166. doi: 10.1007/978-3-030-16908-4_7.