PMID- 31149177
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1841-0987 (Print)
IS  - 1843-066X (Electronic)
IS  - 1841-0987 (Linking)
VI  - 13
IP  - 2
DP  - 2017 Apr-Jun
TI  - THYROID DYSFUNCTION IN AN AIDS PATIENT.
PG  - 220-223
LID - 10.4183/aeb.2017.220 [doi]
AB  - OBJECTIVE: Highly active antiretroviral therapy (HAART) is involved in the 
      potential pathogenic mechanisms linking thyroid autoimmunity with immune 
      restoration. The objective is to emphasize the emergence of autoimmune thyroid 
      disease in a HIV patient long period after restoration of immune competence, 
      unlinked to the immune reconstitution inflammatory syndrome (IRIS) occurring 
      shortly after HAART initiation.We report a case of acute autoimmune thyroiditis 
      with thyrotoxicosis in a patient with stage C3 HIV infection, who had been under 
      HAART for more than 7 years.From the beginning there was a good immune response 
      to the regimen, due to a good adherence and compliance (over 90%). Nine months 
      after HAART initiation the viral load was undetectable (under 34 copies/muL) and 
      the CD4 count reached 645 cells/mm(3) (within normal range) after one year of 
      treatment. Eight years after HAART initiation, based on clinical and laboratory 
      findings, autoimmune thyroiditis was diagnosed. At this time immune competence 
      with a normal CD4 count and a CD4/CD8 ratio over 1 was achieved. The chronic 
      inflammation status of an HIV infection is the reason that autoimmunity appears 
      outside the IRIS period. Treatment was initiated with antithyroid drugs.Thyroid 
      function should be monitored periodically in HIV patients undergoing HAART. 
      Future observations must be made for HIV related thyroid disorders using new 
      classifications and studies with a larger number of patients.
FAU - Gafencu, M
AU  - Gafencu M
AD  - "Victor Babes" University of Medicine and Pharmacy, Dept. of Pediatrics, 
      Timisoara, Romania.
AD  - "Louis Turcanu" Children's Clinical and Emergency Hospital, Dept. of Pediatrics, 
      Timisoara, Romania.
FAU - Bizerea, T O
AU  - Bizerea TO
AD  - "Victor Babes" University of Medicine and Pharmacy, Dept. of Pediatrics, 
      Timisoara, Romania.
AD  - "Louis Turcanu" Children's Clinical and Emergency Hospital, Dept. of Pediatrics, 
      Timisoara, Romania.
FAU - Stroescu, R F
AU  - Stroescu RF
AD  - "Victor Babes" University of Medicine and Pharmacy, Dept. of Pediatrics, 
      Timisoara, Romania.
AD  - "Louis Turcanu" Children's Clinical and Emergency Hospital, Dept. of Pediatrics, 
      Timisoara, Romania.
FAU - Costa, R
AU  - Costa R
AD  - "Louis Turcanu" Children's Clinical and Emergency Hospital, Dept. of Pediatrics, 
      Timisoara, Romania.
FAU - Marginean, O
AU  - Marginean O
AD  - "Victor Babes" University of Medicine and Pharmacy, Dept. of Pediatrics, 
      Timisoara, Romania.
AD  - "Louis Turcanu" Children's Clinical and Emergency Hospital, Dept. of Pediatrics, 
      Timisoara, Romania.
FAU - Doros, G
AU  - Doros G
AD  - "Victor Babes" University of Medicine and Pharmacy, Dept. of Pediatrics, 
      Timisoara, Romania.
AD  - "Louis Turcanu" Children's Clinical and Emergency Hospital, Dept. of Pediatrics, 
      Timisoara, Romania.
LA  - eng
PT  - Case Reports
PL  - Romania
TA  - Acta Endocrinol (Buchar)
JT  - Acta endocrinologica (Bucharest, Romania : 2005)
JID - 101269720
PMC - PMC6516455
OTO - NOTNLM
OT  - HAART
OT  - HIV
OT  - autoimmune thyroiditis
COIS- The authors declare that they have no conflict of interest concerning this 
      article.
EDAT- 2017/04/01 00:00
MHDA- 2017/04/01 00:01
PMCR- 2017/04/01
CRDT- 2019/06/01 06:00
PHST- 2019/06/01 06:00 [entrez]
PHST- 2017/04/01 00:00 [pubmed]
PHST- 2017/04/01 00:01 [medline]
PHST- 2017/04/01 00:00 [pmc-release]
AID - aeb.2017.220 [pii]
AID - 10.4183/aeb.2017.220 [doi]
PST - ppublish
SO  - Acta Endocrinol (Buchar). 2017 Apr-Jun;13(2):220-223. doi: 10.4183/aeb.2017.220.