PMID- 31150016
OWN - NLM
STAT- MEDLINE
DCOM- 20200917
LR  - 20221219
IS  - 1476-5365 (Electronic)
IS  - 0268-3369 (Linking)
VI  - 54
IP  - 12
DP  - 2019 Dec
TI  - Hematopoietic stem cell transplantation with unrelated cord blood or 
      haploidentical donor grafts in adult patients with secondary acute myeloid 
      leukemia, a comparative study from Eurocord and the ALWP EBMT.
PG  - 1987-1994
LID - 10.1038/s41409-019-0582-5 [doi]
AB  - Survival of patients with secondary acute myeloid leukemia (sAML) is poor. Cord 
      blood transplantation (UCBT) and non-T-cell-depleted stem cell transplantation 
      from haploidentical donors (HAPLO) are both strategies that have shown 
      encouraging results in patients who do not have an human leukocyte antigen 
      (HLA)-matched sibling or unrelated donor. We retrospectively analyzed outcomes of 
      409 adults with sAML receiving either UCBT (n = 163) or HAPLO (n = 246) in EBMT 
      centers. Myelodysplastic syndrome (MDS) or myeloproliferative disorder (MPD) was 
      the antecedent diagnosis in 79% of UCBT and 85% of HAPLO recipients. In 
      multivariate analysis, UCBT was associated with higher risk of grade II-IV acute 
      GVHD (HR 1.9, p = 0.009) and lower GHVD-free-relapse-free-survival (GRFS) (HR 
      1.57, p = 0.007) compared to HAPLO. Chronic-GVHD, RI, NRM, LFS, and OS were not 
      statistically different between the two. Early disease stage at transplant was 
      independently associated with lower RI and NRM and higher OS and LFS. These 
      results indicate that HAPLO is associated with better GRFS and lower aGvHD 
      compared to UCBT in patients with sAML and that UCBT can be a valid alternative 
      for sAML patients who lack a matched sibling, a proper haploidentical or an 
      unrelated donor.
FAU - Ruggeri, Annalisa
AU  - Ruggeri A
AD  - Department of Pediatric Hematology and Oncology, IRCCS Bambino Gesu Children's 
      Hospital, Piazza S.Onofrio, 4, Roma, 00165, Italy. annalisaruggeri80@hotmail.com.
FAU - Labopin, Myriam
AU  - Labopin M
AD  - Hopital Saint Antoine, Service d'Hematologie et Therapie Cellulaire, AP-HP, 
      Paris, France.
FAU - Savani, Bipin
AU  - Savani B
AUID- ORCID: 0000-0002-3304-9965
AD  - Vanderbilt University Medical Center, Nashville, TN, USA.
FAU - Paviglianiti, Annalisa
AU  - Paviglianiti A
AD  - Hopital Saint Antoine, Service d'Hematologie et Therapie Cellulaire, AP-HP, 
      Paris, France.
FAU - Blaise, Didier
AU  - Blaise D
AUID- ORCID: 0000-0002-5684-9447
AD  - Institut Paoli Calmettes, Marseille, France.
FAU - Volt, Fernanda
AU  - Volt F
AD  - Hopital Saint Louis, Eurocord, IUH University Paris VII, Paris, France.
AD  - Monacord, Centre Scientifique de Monaco, Monaco, Monaco.
FAU - Ciceri, Fabio
AU  - Ciceri F
AD  - Hematology and BMT Unit, San Raffaele Scientific Institute, Milano, Italy.
FAU - Bacigalupo, Andrea
AU  - Bacigalupo A
AD  - Hematology Department, Fondazione Policlinico Universitario Agostino Gemelli, 
      Universita' Cattolica deI Sacro Cuore, Rome, Italy.
FAU - Tischer, Johanna
AU  - Tischer J
AD  - Ludwig Maximilian University Hospital of Munich, Munich, Germany.
FAU - Chevallier, Patrice
AU  - Chevallier P
AD  - Service d'hematologie, Hotel Dieu, Nantes, France.
FAU - Koc, Yener
AU  - Koc Y
AD  - Medical Park, Stem Cell Transplant Unit, Antalya, Turkey.
FAU - Cornelissen, Jan J
AU  - Cornelissen JJ
AD  - Erasmus MC Cancer Institute, University Medical Centre, Rotterdam, The 
      Netherlands.
FAU - Ehninger, Gerard
AU  - Ehninger G
AD  - Universitatsklinikum Carl Gustav Carus der TU Dresden, Medizinische Klinik und 
      Poliklinik I, Dresden, Germany.
FAU - Sanz, Guillermo
AU  - Sanz G
AUID- ORCID: 0000-0002-2767-8191
AD  - Hospital Universitario y Politecnico La Fe, Valencia, Spain.
AD  - CIBERONC, Madrid, Spain.
FAU - Deconinck, Erick
AU  - Deconinck E
AUID- ORCID: 0000-0002-6006-8088
AD  - Hopital Jean Minjoz, Service d'Hematologie, Besancon, France.
FAU - Rocha, Vanderson
AU  - Rocha V
AD  - Hopital Saint Louis, Eurocord, IUH University Paris VII, Paris, France.
AD  - Monacord, Centre Scientifique de Monaco, Monaco, Monaco.
FAU - Baron, Frederic
AU  - Baron F
AD  - Department of Hematology, CHU of Liege, 4000, Liege, Belgium.
FAU - Mohty, Mohamad
AU  - Mohty M
AD  - Hopital Saint Antoine, Service d'Hematologie et Therapie Cellulaire, AP-HP, 
      Paris, France.
AD  - INSERM, UMRs 938, Paris, France.
FAU - Gluckman, Eliane
AU  - Gluckman E
AD  - Hopital Saint Louis, Eurocord, IUH University Paris VII, Paris, France.
AD  - Monacord, Centre Scientifique de Monaco, Monaco, Monaco.
FAU - Nagler, Arnon
AU  - Nagler A
AD  - Hopital Saint Antoine, Service d'Hematologie et Therapie Cellulaire, AP-HP, 
      Paris, France.
AD  - Chaim Sheba Medical Center, Tel-Hashomer, Israel.
LA  - eng
PT  - Historical Article
PT  - Journal Article
DEP - 20190531
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
SB  - IM
MH  - Cord Blood Stem Cell Transplantation/*methods
MH  - Female
MH  - Hematopoietic Stem Cell Transplantation/*methods
MH  - History, 20th Century
MH  - Humans
MH  - Leukemia, Myeloid, Acute/*therapy
MH  - Male
MH  - Transplantation Conditioning/*methods
MH  - Transplantation, Haploidentical/*methods
MH  - Unrelated Donors
EDAT- 2019/06/01 06:00
MHDA- 2020/09/18 06:00
CRDT- 2019/06/01 06:00
PHST- 2019/02/04 00:00 [received]
PHST- 2019/05/15 00:00 [accepted]
PHST- 2019/04/17 00:00 [revised]
PHST- 2019/06/01 06:00 [pubmed]
PHST- 2020/09/18 06:00 [medline]
PHST- 2019/06/01 06:00 [entrez]
AID - 10.1038/s41409-019-0582-5 [pii]
AID - 10.1038/s41409-019-0582-5 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2019 Dec;54(12):1987-1994. doi: 
      10.1038/s41409-019-0582-5. Epub 2019 May 31.