PMID- 31150720
OWN - NLM
STAT- MEDLINE
DCOM- 20200203
LR  - 20200203
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 156
DP  - 2019 Oct
TI  - Protective effect of umbilical cord mesenchymal stem cells combined with 
      resveratrol against renal podocyte damage in NOD mice.
PG  - 107755
LID - S0168-8227(19)30381-X [pii]
LID - 10.1016/j.diabres.2019.05.034 [doi]
AB  - BACKGROUND: The role of chronic inflammation initiated by persistent 
      hyperglycemia in podocyte injury has attracted increasing attention. The advanced 
      glycation end products (RAGE) receptor- nuclear factor-kappa B (NF-small ka, CyrillicB) signaling 
      pathway is involved in the occurrence of inflammation. We speculate that 
      treatment with human umbilical cord mesenchymal stem cells (hUCMSCs) combined 
      with resveratrol can block this signaling pathway and protect podocyte function. 
      METHODS: Non obesity diabetes(NOD) mice were randomly divided into 5 groups: 
      NOD-T1DM, Res, hUCMSCs, hUCMSCs + Res and insulin (INS)groups. Mice without 
      diabetes were classified as NOD control group(NOD group). Blood glucose(BG), 
      blood urea nitrogen(BUN), serum creatinine(SCr), 24-h urine albumin excretion 
      rate (UAER) were measured. The expression of nephrin, WT1 and RAGE, MCP-1 in 
      renal tissues were detected by Western blot, expression of NF-small ka, CyrillicB protein(P65) was 
      determined by immunohistochemistry. RESULTS: The combined treatment of hUCMSCs 
      and Resveratrol can reduce BG, BUN, SCr, 24-h UAER, and the expression of the 
      inflammatory factors MCP-1, RAGE and NF-small ka, CyrillicB; increase the number of podocytes and 
      the expression of the podocyte-related proteins nephrin and WT1 in type 1 
      diabetes mellitus, and improve renal pathological structure. CONCLUSIONS: 
      Combining of hUCMSCs and resveratrol can better protect renal podocyte function, 
      and the effects on the reduction of blood glucose and renal injury are better 
      than those obtained by insulin treatment. This indicated that the combination of 
      Res and hUCMSCs may be a novel therapeutic method for the treatment of DN.
CI  - Copyright (c) 2019. Published by Elsevier B.V.
FAU - Xian, Yuxin
AU  - Xian Y
AD  - Department of Endocrinology, The Affiliated Hospital of Qingdao University, 
      Qingdao 266003, China.
FAU - Lin, Yi
AU  - Lin Y
AD  - Department of Pediatric, The Affiliated Hospital of Qingdao University, Qingdao 
      266003, China.
FAU - Cao, Caixia
AU  - Cao C
AD  - Department of Endocrinology, The Affiliated Hospital of Qingdao University, 
      Qingdao 266003, China.
FAU - Li, Li
AU  - Li L
AD  - Department of Endocrinology, The Affiliated Hospital of Qingdao University, 
      Qingdao 266003, China.
FAU - Wang, Jing
AU  - Wang J
AD  - Department of Endocrinology, The Affiliated Hospital of Qingdao University, 
      Qingdao 266003, China.
FAU - Niu, Jiapeng
AU  - Niu J
AD  - Department of Endocrinology, The Affiliated Hospital of Qingdao University, 
      Qingdao 266003, China.
FAU - Guo, Yunlei
AU  - Guo Y
AD  - Department of Endocrinology, The Affiliated Hospital of Qingdao University, 
      Qingdao 266003, China.
FAU - Sun, Yanan
AU  - Sun Y
AD  - Department of Endocrinology, The Affiliated Hospital of Qingdao University, 
      Qingdao 266003, China.
FAU - Wang, Yangang
AU  - Wang Y
AD  - Department of Endocrinology, The Affiliated Hospital of Qingdao University, 
      Qingdao 266003, China. Electronic address: wangyg1966@icloud.com.
FAU - Wang, Wei
AU  - Wang W
AD  - Department of Hematology, The Affiliated Hospital of Qingdao University, Qingdao 
      266003, China. Electronic address: 18661807392@163.com.
LA  - eng
PT  - Journal Article
DEP - 20190528
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - Q369O8926L (Resveratrol)
SB  - IM
MH  - Animals
MH  - Female
MH  - Humans
MH  - Inflammation/*complications
MH  - Mesenchymal Stem Cells/*metabolism
MH  - Mice
MH  - Mice, Inbred NOD
MH  - Podocytes/*metabolism
MH  - Resveratrol/pharmacology/*therapeutic use
OTO - NOTNLM
OT  - Diabetic nephropathy
OT  - Podocyte
OT  - Resveratrol
OT  - Umbilical cord mesenchymal stem cells
EDAT- 2019/06/01 06:00
MHDA- 2020/02/06 06:00
CRDT- 2019/06/01 06:00
PHST- 2019/03/16 00:00 [received]
PHST- 2019/04/28 00:00 [revised]
PHST- 2019/05/23 00:00 [accepted]
PHST- 2019/06/01 06:00 [pubmed]
PHST- 2020/02/06 06:00 [medline]
PHST- 2019/06/01 06:00 [entrez]
AID - S0168-8227(19)30381-X [pii]
AID - 10.1016/j.diabres.2019.05.034 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2019 Oct;156:107755. doi: 10.1016/j.diabres.2019.05.034. 
      Epub 2019 May 28.