PMID- 31152489
OWN - NLM
STAT- MEDLINE
DCOM- 20200804
LR  - 20210109
IS  - 1542-474X (Electronic)
IS  - 1082-720X (Print)
IS  - 1082-720X (Linking)
VI  - 24
IP  - 5
DP  - 2019 Sep
TI  - The relationship between myocardial fibrosis detected by cardiac magnetic 
      resonance and Tp-e interval, 5-year sudden cardiac death risk score in 
      hypertrophic cardiomyopathy patients.
PG  - e12672
LID - 10.1111/anec.12672 [doi]
LID - e12672
AB  - BACKGROUND: The aim of this study was to investigate the relationship between QT 
      (QTc) interval, Tp-e interval, Tp-e/QTc ratio, 5-year sudden cardiac death (SCD) 
      risk score, and late gadolinium enhancement (LGE) detected by CMR in hypertrophic 
      cardiomyopathy (HCM) patients. METHOD: A total of 74 consecutive patients who 
      underwent CMR with HCM diagnosis were included in the study. These patients were 
      divided into two groups according to the presence of LGE on CMR. All patients 
      underwent detailed echocardiography and QTc interval, Tp-e interval, and Tp-e/QTc 
      ratios and 5-year SCD risk scores were calculated. These parameters were compared 
      for two groups. RESULTS: CMR revealed LGE in 32 (43.2%) of 74 HCM patients. In 
      the group with LGE, significantly higher QTc interval (p = 0.002), Tp-e interval 
      (p < 0.001), Tp-e/QTc ratio (p = 0.004), and 5-year SCD risk score were detected. 
      In addition, QTc interval, Tp-e interval, Tp-e/QTc ratio, maximum wall thickness, 
      left ventricular mass index, 5-year SCD risk score, and cardiac fibrosis index 
      were found to be correlated with various degrees in correlation analysis. Also, 
      Tp-e interval is found to be an independent predictor of LGE detected by CMR in 
      HCM patients (p = 0.017, OR [%95 CI] = 1.017 [1.001-1.034]). In addition, the 
      Tp-e interval can detect the LGE with a sensitivity of 64.3% and a specificity of 
      84.2% at 99.4 ms. (p < 0.001, AUC [95% CI] = 0.790 [0.676-0.905]). CONCLUSION: 
      The Tp-e interval can be used to optimize SCD risk stratification in HCM patients 
      and determine which patients will benefit from implantable 
      cardioverter-defibrillator (ICD) treatment.
CI  - (c) 2019 Wiley Periodicals, Inc.
FAU - Riza Demir, Ali
AU  - Riza Demir A
AD  - Department of Cardiology, University of Health Science, Istanbul Mehmet Akif 
      Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, 
      Istanbul, Turkey.
FAU - Celik, Omer
AU  - Celik O
AD  - Department of Cardiology, University of Health Science, Istanbul Mehmet Akif 
      Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, 
      Istanbul, Turkey.
FAU - Sevinc, Samet
AU  - Sevinc S
AD  - Department of Cardiology, Akcakale State Hospital, Urfa, Turkey.
FAU - Uygur, Begum
AU  - Uygur B
AD  - Department of Cardiology, University of Health Science, Istanbul Mehmet Akif 
      Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, 
      Istanbul, Turkey.
FAU - Kahraman, Serkan
AU  - Kahraman S
AUID- ORCID: 0000-0003-2796-0987
AD  - Department of Cardiology, University of Health Science, Istanbul Mehmet Akif 
      Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, 
      Istanbul, Turkey.
FAU - Yilmaz, Emre
AU  - Yilmaz E
AD  - Department of Cardiology, University of Health Science, Istanbul Mehmet Akif 
      Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, 
      Istanbul, Turkey.
FAU - Cemek, Mete
AU  - Cemek M
AD  - Department of Cardiology, Karaman State Hospital, Karaman, Turkey.
FAU - Onal, Yilmaz
AU  - Onal Y
AD  - Department of Radiology, Istanbul Fatih Sultan Mehmet Training and Research 
      Hospital, Istanbul, Turkey.
FAU - Erturk, Mehmet
AU  - Erturk M
AD  - Department of Cardiology, University of Health Science, Istanbul Mehmet Akif 
      Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, 
      Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20190601
PL  - United States
TA  - Ann Noninvasive Electrocardiol
JT  - Annals of noninvasive electrocardiology : the official journal of the 
      International Society for Holter and Noninvasive Electrocardiology, Inc
JID - 9607443
RN  - 0 (Contrast Media)
SB  - IM
MH  - Cardiomyopathy, Hypertrophic/*diagnostic imaging/*physiopathology
MH  - Contrast Media
MH  - *Death, Sudden, Cardiac
MH  - Echocardiography
MH  - Electrocardiography
MH  - Female
MH  - Fibrosis
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Risk Factors
PMC - PMC6931578
OTO - NOTNLM
OT  - Tp-e interval
OT  - cardiac magnetic resonance
OT  - hypertrophic cardiomyopathy
OT  - late gadolinium enhancement
OT  - sudden cardiac death
EDAT- 2019/06/04 06:00
MHDA- 2020/08/05 06:00
PMCR- 2019/06/01
CRDT- 2019/06/02 06:00
PHST- 2018/12/11 00:00 [received]
PHST- 2019/03/19 00:00 [revised]
PHST- 2019/03/25 00:00 [accepted]
PHST- 2019/06/04 06:00 [pubmed]
PHST- 2020/08/05 06:00 [medline]
PHST- 2019/06/02 06:00 [entrez]
PHST- 2019/06/01 00:00 [pmc-release]
AID - ANEC12672 [pii]
AID - 10.1111/anec.12672 [doi]
PST - ppublish
SO  - Ann Noninvasive Electrocardiol. 2019 Sep;24(5):e12672. doi: 10.1111/anec.12672. 
      Epub 2019 Jun 1.