PMID- 31152776
OWN - NLM
STAT- MEDLINE
DCOM- 20200911
LR  - 20200911
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 124
DP  - 2019 Sep
TI  - Monocyte chemoattractant protein-1 (MCP-1) and fibroblast growth factor-21 
      (FGF-21) as biomarkers of subclinical atherosclerosis in women.
PG  - 110624
LID - S0531-5565(18)30727-7 [pii]
LID - 10.1016/j.exger.2019.05.013 [doi]
AB  - BACKGROUND: Atherosclerosis is a primary risk factor for cardiovascular disease 
      (CVD). Proinflammatory biochemical factors can influence vascular health; 
      monocyte chemoattractant protein-1 (MCP-1) is elevated in patients with CVD while 
      fibroblast growth factor-21 (FGF-21) acts directly on cardiac tissue to reduce 
      infarction damage. However, the relationship between plasma concentrations of 
      MCP-1, FGF-21 and subclinical CVD indices remains equivocal. AIM: To determine 
      the association between MCP-1, FGF-21 and subclinical atherosclerosis [i.e., 
      carotid intima-media thickness (cIMT)] in women without clinical evidence of CVD. 
      METHODS: A cross-sectional analysis of 140 women without history of CVD was 
      performed. Anthropometrics were collected, serum concentrations of MCP-1 and 
      FGF-21 were determined by enzyme-linked immunosorbent assay, and cIMT was 
      quantified (B-mode ultrasonography). The correlations between MCP-1, FGF-21 and 
      the presence of clinical and laboratory of subclinical atherosclerosis (i.e., 
      cIMT >/=0.70 mm), comparison intergroup and odd ratio with multiple logistic 
      regression were analyzed. RESULTS: MCP-1, but not FGF-21 correlated with some 
      obesity indicators. In median comparison among groups, subclinical 
      atherosclerosis showed higher serum concentrations of MCP-1and lower serum 
      concentrations of FGF-21. In postmenopausal women, there were significant 
      differences MCP-1 (p = 0.001), and FGF-21 (p = 0.010). Multiple logistic 
      regression analysis in postmenopausal women with subclinical atherosclerosis, 
      between MCP-1 (p = 0.001) and FGF-21 (p = 0.037) showed association with cIMT, 
      along with age. CONCLUSIONS: MCP-1 and FGF-21 levels are associated with 
      subclinical atherosclerosis disease severity (i.e., cIMT) in postmenopausal women 
      without CVD. Further efforts focused on characterizing the relationship between 
      novel blood-borne markers of early CVD pathology are warranted and should be 
      pursued.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Basurto, Lourdes
AU  - Basurto L
AD  - Health Research Coordination, Centro Medico Nacional, Instituto Mexicano del 
      Seguro Social (IMSS), Mexico.
FAU - Gregory, Michael A
AU  - Gregory MA
AD  - School of Rehabilitation Sciences, Faculty of Health Sciences, McMaster 
      University, Hamilton, Ontario, Canada. Electronic address: gregom2@mcmaster.ca.
FAU - Hernandez, Susana Barrera
AU  - Hernandez SB
AD  - Health Research Coordination, Centro Medico Nacional, Instituto Mexicano del 
      Seguro Social (IMSS), Mexico.
FAU - Sanchez-Huerta, Lucero
AU  - Sanchez-Huerta L
AD  - Health Research Coordination, Centro Medico Nacional, Instituto Mexicano del 
      Seguro Social (IMSS), Mexico.
FAU - Martinez, Alma Diaz
AU  - Martinez AD
AD  - Health Research Coordination, Centro Medico Nacional, Instituto Mexicano del 
      Seguro Social (IMSS), Mexico.
FAU - Manuel-Apolinar, Leticia
AU  - Manuel-Apolinar L
AD  - Health Research Coordination, Centro Medico Nacional, Instituto Mexicano del 
      Seguro Social (IMSS), Mexico.
FAU - Avelar, Francisco J
AU  - Avelar FJ
AD  - Departament of Radiology, Hospital de Especialidades, Centro Medico Nacional, 
      Instituto Mexicano del Seguro Social (IMSS), Mexico. Electronic address: 
      francisco.avelar@imss.gob.mx.
FAU - Alonso, Laura Alejandra Mejia
AU  - Alonso LAM
AD  - Health Research Coordination, Centro Medico Nacional, Instituto Mexicano del 
      Seguro Social (IMSS), Mexico.
FAU - Sanchez-Arenas, Rosalinda
AU  - Sanchez-Arenas R
AD  - Research Unit in Epidemiology and Health Services, Centro Medico Nacional, 
      Instituto Mexicano del Seguro Social (IMSS), Mexico. Electronic address: 
      felicitasarenas@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190529
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (fibroblast growth factor 21)
RN  - 62031-54-3 (Fibroblast Growth Factors)
SB  - IM
MH  - Atherosclerosis/*blood/diagnostic imaging
MH  - Biomarkers/blood
MH  - Carotid Arteries/diagnostic imaging
MH  - Carotid Intima-Media Thickness
MH  - Chemokine CCL2/*blood
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fibroblast Growth Factors/*blood
MH  - Humans
MH  - Logistic Models
MH  - Mexico
MH  - Middle Aged
MH  - Obesity/complications
MH  - Postmenopause/*blood
MH  - Risk Factors
OTO - NOTNLM
OT  - Atherosclerosis
OT  - Cardiovascular risk factor
OT  - Carotid IMT
OT  - FGF-21
OT  - MCP-1
OT  - Postmenopausal women
EDAT- 2019/06/04 06:00
MHDA- 2020/09/12 06:00
CRDT- 2019/06/02 06:00
PHST- 2018/11/15 00:00 [received]
PHST- 2019/05/28 00:00 [revised]
PHST- 2019/05/28 00:00 [accepted]
PHST- 2019/06/04 06:00 [pubmed]
PHST- 2020/09/12 06:00 [medline]
PHST- 2019/06/02 06:00 [entrez]
AID - S0531-5565(18)30727-7 [pii]
AID - 10.1016/j.exger.2019.05.013 [doi]
PST - ppublish
SO  - Exp Gerontol. 2019 Sep;124:110624. doi: 10.1016/j.exger.2019.05.013. Epub 2019 
      May 29.