PMID- 31153898
OWN - NLM
STAT- MEDLINE
DCOM- 20200520
LR  - 20200825
IS  - 1096-0333 (Electronic)
IS  - 0041-008X (Linking)
VI  - 378
DP  - 2019 Sep 1
TI  - Evaluation of brain SERT with 4-[(18)F]-ADAM/micro-PET and hearing protective 
      effects of dextromethorphan in hearing loss rat model.
PG  - 114604
LID - S0041-008X(19)30206-6 [pii]
LID - 10.1016/j.taap.2019.114604 [doi]
AB  - This study investigated the protective effects of dextromethorphan (DXM) on 
      noise-induced hearing loss (NIHL) in rats. This study aimed to improve the 
      auditory threshold and to understand the protective effects of DXM against 
      N-methyl-d-aspartate (NMDA)-induced neurite degeneration of serotonergic neurons. 
      The animals were exposed to 8-kHz narrowband noise at a 118-dB sound pressure 
      level for 3.5 h. The hearing thresholds were determined by measuring the auditory 
      brainstem response to click stimuli. Serotonin transporter (SERT) expression was 
      determined through micro-positron emission tomography (PET) using 
      N,N-dimethyl-2-(2-amino-4-(18)F-fluorophenylthio)benzylamine (4-[(18)F]-ADAM). We 
      also investigated the effects of DXM on NMDA-induced morphological changes in the 
      primary cultures of rat serotonergic neurons. NIHL significantly improved after 
      prophylactic treatment with DXM (p < .05). SERT density in DXM-treated rats was 
      significantly higher than that in non-DXM-treated rats. Because prophylactic 
      medication restored the NMDA-inhibited neurite length of serotonergic neurons and 
      presented SERT density, DXM could be a potential agent in alleviating NIHL.
CI  - Copyright (c) 2019 Elsevier Inc. All rights reserved.
FAU - Liu, Cheng-Tsung
AU  - Liu CT
AD  - Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, 
      Taiwan; Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, 
      Taiwan.
FAU - Huang, Yuahn-Sieh
AU  - Huang YS
AD  - Department of Biology and Anatomy, National Defense Medical Center, Taipei, 
      Taiwan.
FAU - Chen, Hsin-Chien
AU  - Chen HC
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Tri-Service General 
      Hospital, Taipei, Taiwan.
FAU - Ma, Kuo-Hsing
AU  - Ma KH
AD  - Department of Biology and Anatomy, National Defense Medical Center, Taipei, 
      Taiwan.
FAU - Wang, Chih-Hung
AU  - Wang CH
AD  - Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, 
      Taiwan; Department of Otorhinolaryngology, Taichung Armed Forces General 
      Hospital, Taichung, Taiwan.
FAU - Chiu, Chuang-Hsin
AU  - Chiu CH
AD  - Department of Nuclear Medicine, Tri-Service General Hospital, Taipei, Taiwan.
FAU - Shih, Jui-Hu
AU  - Shih JH
AD  - Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, Taiwan; 
      School of Pharmacy, National Defense Medical Center, Taipei, Taiwan.
FAU - Kang, Hsiao-Hsien
AU  - Kang HH
AD  - Universal Eye Center, Taipei, Taiwan.
FAU - Shiue, Chyng-Yann
AU  - Shiue CY
AD  - Department of Nuclear Medicine, Tri-Service General Hospital, Taipei, Taiwan.
FAU - Li, I-Hsun
AU  - Li IH
AD  - Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, 
      Taiwan; Department of Pharmacy Practice, Tri-Service General Hospital, Taipei, 
      Taiwan; School of Pharmacy, National Defense Medical Center, Taipei, Taiwan. 
      Electronic address: lhs01077@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190530
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Benzylamines)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (Radiopharmaceuticals)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - 0 (Sert1 protein, rat)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 7355X3ROTS (Dextromethorphan)
RN  - A1O31ROR09 (benzylamine)
SB  - IM
MH  - Animals
MH  - Benzylamines/*pharmacology
MH  - Brain/*drug effects/metabolism
MH  - Brain Stem/drug effects/metabolism
MH  - Dextromethorphan/*pharmacology
MH  - Disease Models, Animal
MH  - Evoked Potentials, Auditory, Brain Stem/drug effects
MH  - Hearing Loss/*drug therapy/*metabolism
MH  - Male
MH  - N-Methylaspartate/pharmacology
MH  - Positron-Emission Tomography/methods
MH  - RNA-Binding Proteins/*metabolism
MH  - Radiopharmaceuticals/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonergic Neurons/drug effects/metabolism
MH  - Serotonin Plasma Membrane Transport Proteins/metabolism
OTO - NOTNLM
OT  - 4-[(18)F]-ADAM
OT  - Dextromethorphan
OT  - Micro-PET
OT  - Noise-Induced Hearing Loss
OT  - SERT
EDAT- 2019/06/04 06:00
MHDA- 2020/05/21 06:00
CRDT- 2019/06/03 06:00
PHST- 2018/11/22 00:00 [received]
PHST- 2019/05/02 00:00 [revised]
PHST- 2019/05/29 00:00 [accepted]
PHST- 2019/06/04 06:00 [pubmed]
PHST- 2020/05/21 06:00 [medline]
PHST- 2019/06/03 06:00 [entrez]
AID - S0041-008X(19)30206-6 [pii]
AID - 10.1016/j.taap.2019.114604 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 2019 Sep 1;378:114604. doi: 10.1016/j.taap.2019.114604. 
      Epub 2019 May 30.