PMID- 31154422
OWN - NLM
STAT- MEDLINE
DCOM- 20191015
LR  - 20191015
IS  - 1472-4146 (Electronic)
IS  - 0021-9746 (Linking)
VI  - 72
IP  - 10
DP  - 2019 Oct
TI  - Optimal sampling of pelvic lymphadenectomy specimens following radical 
      prostatectomy: is complete tissue submission justified?
PG  - 712-715
LID - 10.1136/jclinpath-2019-205839 [doi]
AB  - There is currently no consensus among pathologists on the optimal method of 
      sampling pelvic lympadenectomy specimens (PLND) in prostate cancer. We evaluated 
      the impact of complete PLND submission on lymph node (LN) yield, detection of 
      metastasis and laboratory workload in a series of 141 cases. Following isolation 
      of grossly identifiable LNs/potential LNs, the remaining fatty tissue was 
      embedded in toto. Complete PLND submission increased median LN yield from 10 
      (1-42) to 17 (3-57). Metastatic deposits were identified in nine non-palpable 
      LNs, which altered the pN category in four cases (3%). The primary tumour (pT) 
      was grade group >/=3 and/or pT3 at radical prostatectomy in 96% of pN+ cases. A 
      median of seven additional blocks (1-28) was required for complete tissue 
      embedding. Our findings indicate that submission of the entire fat can optimise 
      PLND assessment but has a significant impact on laboratory workload. Complete 
      submission of selected high-risk cases may be a reasonable alternative.
CI  - (c) Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and 
      permissions. Published by BMJ.
FAU - Ni Mhaolcatha, Sarah
AU  - Ni Mhaolcatha S
AD  - Department of Histopathology, Cork University Hospital, Cork, Ireland.
FAU - Power, Elaine
AU  - Power E
AD  - Department of Histopathology, Cork University Hospital, Cork, Ireland.
FAU - Mayer, Nick
AU  - Mayer N
AD  - Department of Histopathology, Cork University Hospital, Cork, Ireland.
FAU - Prendeville, Susan
AU  - Prendeville S
AUID- ORCID: 0000-0002-1068-355X
AD  - Department of Histopathology, Cork University Hospital, Cork, Ireland 
      susan.prendeville@hse.ie.
LA  - eng
PT  - Journal Article
DEP - 20190601
PL  - England
TA  - J Clin Pathol
JT  - Journal of clinical pathology
JID - 0376601
SB  - IM
MH  - Humans
MH  - Lymph Node Excision
MH  - Lymph Nodes/pathology/surgery
MH  - Male
MH  - Prostate/pathology/surgery
MH  - Prostatectomy
MH  - Prostatic Neoplasms/pathology/*surgery
MH  - Specimen Handling
OTO - NOTNLM
OT  - lymph node
OT  - lymphadenectomy
OT  - prostate cancer
COIS- Competing interests: None declared.
EDAT- 2019/06/04 06:00
MHDA- 2019/10/16 06:00
CRDT- 2019/06/03 06:00
PHST- 2019/03/13 00:00 [received]
PHST- 2019/04/22 00:00 [revised]
PHST- 2019/04/23 00:00 [accepted]
PHST- 2019/06/04 06:00 [pubmed]
PHST- 2019/10/16 06:00 [medline]
PHST- 2019/06/03 06:00 [entrez]
AID - jclinpath-2019-205839 [pii]
AID - 10.1136/jclinpath-2019-205839 [doi]
PST - ppublish
SO  - J Clin Pathol. 2019 Oct;72(10):712-715. doi: 10.1136/jclinpath-2019-205839. Epub 
      2019 Jun 1.