PMID- 31155146 OWN - NLM STAT- MEDLINE DCOM- 20200520 LR - 20221207 IS - 1879-114X (Electronic) IS - 0149-2918 (Linking) VI - 41 IP - 8 DP - 2019 Aug TI - Treatment Patterns in Patients With Newly Diagnosed Type 2 Diabetes in China: A Retrospective, Longitudinal Database Study. PG - 1440-1452 LID - S0149-2918(19)30248-6 [pii] LID - 10.1016/j.clinthera.2019.05.003 [doi] AB - PURPOSE: The objectives of this study were to examine the patterns of antihyperglycemic drug (AHD) therapy among patients with newly diagnosed type 2 diabetes mellitus (T2DM) in the general Chinese population, stratified by initial hemoglobin (Hb) A(1c) level, and to assess whether treatment patterns are consistent with the recommendations published in the China Diabetes Society's clinical treatment guideline. METHODS: A retrospective database analysis was conducted, and data were obtained from the SuValue database. Prescribing patterns for diabetes treatments were determined from data obtained from the Nanhai District-based electronic medical records database, a subset of the SuValue database. Data from patients newly diagnosed with T2DM who also had at least 2 prescriptions for AHD medications after diagnosis and at least 1 HbA(1c) test result during the 12 months prior to AHD treatment initiation, between January 1, 2004, and July 22, 2018, were included in the analysis. ANOVA, chi(2) test, and Kaplan-Meier survival analysis were used to examine differences between 4 initial-HbA(1c) groups (<7%, 7%-<8%, 8%-<9%, and >/=9%). FINDINGS: A total of 4712 patients were included, with women accounting for 47.8%; the mean age (SD) of the study population was 56.44 (12.57) years. Men were more likely to have had a higher HbA(1c) level at initial AHD treatment (P < 0.0001). The first-line therapies most frequently prescribed were metformin combination (29.5%), followed by insulin-including treatment (25.9%), and metformin monotherapy (19.2%). Metformin monotherapy (29.5%) was most commonly prescribed in patients with an HbA(1c) level of <7%; metformin combination (31.7%), in patients with an HbA(1c) level of 7%-<8%; and insulin-containing treatment, in patients with HbA(1c) levels of 8%-<9% (28.1%) and >/=9% (38.4%). Insulin-including treatment was more commonly prescribed than was metformin combination in patients with an initial HbA(1c) level of >/=8% after initial treatment. In third- and fourth-line treatments, patients with an HbA(1c) level of >/=8% more prevalently were prescribed metformin combination and insulin-including treatment, while metformin combination and "other" treatment were more generally prescribed in patients with an HbA(1c) level of