PMID- 31155539
OWN - NLM
STAT- MEDLINE
DCOM- 20200320
LR  - 20200320
IS  - 1348-4540 (Electronic)
IS  - 0918-8959 (Linking)
VI  - 66
IP  - 9
DP  - 2019 Sep 28
TI  - Preserving beta-cell function is the major determinant of diabetes remission 
      following laparoscopic sleeve gastrectomy in Japanese obese diabetic patients.
PG  - 817-826
LID - 10.1507/endocrj.EJ19-0054 [doi]
AB  - Laparoscopic sleeve gastrectomy has been proven effective in treating 
      obesity-associated type 2 diabetes mellitus (T2DM). However, reports of the 
      effect of laparoscopic sleeve gastrectomy on glucose metabolism in Japanese obese 
      patients with T2DM are rare. The aim of this study was to evaluate the effects of 
      laparoscopic sleeve gastrectomy on glucose tolerance in Japanese obese patients 
      with T2DM, and to analyze factors influencing diabetes remission after surgery. 
      This was a retrospective analysis of data for 24 consecutive patients with T2DM 
      who underwent laparoscopic sleeve gastrectomy. We investigated weight loss and 
      its impact on T2DM 1 year postoperatively. We also compared baseline 
      characteristics and postoperative factors between patients who achieved diabetes 
      remission and patients without remission. Mean body weight loss and percent total 
      weight loss were 23.9 kg and 23.3%, respectively. Mean hemoglobin A1c levels 
      dropped from 7.3 +/- 0.3% to 6.1 +/- 0.2%, and 18 patients (75%) achieved diabetes 
      remission 1 year postoperatively. Patients achieving remission had significantly 
      lower hemoglobin A1c levels (p = 0.026), higher fasting C-peptide values (p < 
      0.001), shorter diabetes duration (p < 0.001), lower insulin requirement (p = 
      0.002), and higher area under the insulin response curve (p < 0.001) and 
      insulinogenic index (p < 0.001) during oral glucose tolerance testing. In 
      conclusion, laparoscopic sleeve gastrectomy is an effective treatment for 
      Japanese obese patients with T2DM. Preserving insulin secretion is the major 
      determinant of diabetes remission.
FAU - Ugi, Satoshi
AU  - Ugi S
AD  - Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 
      520-2192, Japan.
FAU - Morino, Katsutaro
AU  - Morino K
AD  - Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 
      520-2192, Japan.
FAU - Yamaguchi, Tsuyoshi
AU  - Yamaguchi T
AD  - Department of Surgery, Shiga University of Medical Science, Otsu, Shiga 520-2192, 
      Japan.
FAU - Yamamoto, Hiroshi
AU  - Yamamoto H
AD  - Department of Surgery, Kohnan Hospital, Koka, Shiga 520-3321, Japan.
FAU - Kaida, Sachiko
AU  - Kaida S
AD  - Department of Surgery, Shiga University of Medical Science, Otsu, Shiga 520-2192, 
      Japan.
FAU - Miyazawa, Itsuko
AU  - Miyazawa I
AD  - Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 
      520-2192, Japan.
FAU - Sato, Daisuke
AU  - Sato D
AD  - Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 
      520-2192, Japan.
FAU - Sekine, Osamu
AU  - Sekine O
AD  - Department of Medicine, Kusatsu General Hospital, Kusatsu, Shiga 525-8585, Japan.
FAU - Fujita, Yukihiro
AU  - Fujita Y
AD  - Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 
      520-2192, Japan.
FAU - Kashiwagi, Atsunori
AU  - Kashiwagi A
AD  - Department of Medicine, Kusatsu General Hospital, Kusatsu, Shiga 525-8585, Japan.
FAU - Tani, Masaji
AU  - Tani M
AD  - Department of Surgery, Shiga University of Medical Science, Otsu, Shiga 520-2192, 
      Japan.
FAU - Maegawa, Hiroshi
AU  - Maegawa H
AD  - Department of Medicine, Shiga University of Medical Science, Otsu, Shiga 
      520-2192, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190601
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - *Cytoprotection/physiology
MH  - Diabetes Mellitus, Type 2/blood/complications/physiopathology/*surgery
MH  - Female
MH  - Follow-Up Studies
MH  - *Gastrectomy/methods
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin-Secreting Cells/*physiology
MH  - Japan
MH  - Laparoscopy
MH  - Male
MH  - Middle Aged
MH  - Obesity/blood/complications/physiopathology/*surgery
MH  - Postoperative Period
MH  - Remission Induction
MH  - Retrospective Studies
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Bariatric surgery
OT  - Diabetes remission
OT  - Laparoscopic sleeve gastrectomy
OT  - Type 2 diabetes mellitus
OT  - beta-cell function
EDAT- 2019/06/04 06:00
MHDA- 2020/03/21 06:00
CRDT- 2019/06/04 06:00
PHST- 2019/06/04 06:00 [pubmed]
PHST- 2020/03/21 06:00 [medline]
PHST- 2019/06/04 06:00 [entrez]
AID - 10.1507/endocrj.EJ19-0054 [doi]
PST - ppublish
SO  - Endocr J. 2019 Sep 28;66(9):817-826. doi: 10.1507/endocrj.EJ19-0054. Epub 2019 
      Jun 1.