PMID- 31156637
OWN - NLM
STAT- MEDLINE
DCOM- 20200909
LR  - 20200909
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 10
DP  - 2019
TI  - Human Dendritic Cell Subsets, Ontogeny, and Impact on HIV Infection.
PG  - 1088
LID - 10.3389/fimmu.2019.01088 [doi]
LID - 1088
AB  - Dendritic cells (DCs) play important roles in orchestrating host immunity against 
      invading pathogens, representing one of the first responders to infection by 
      mucosal invaders. From their discovery by Ralph Steinman in the 1970s followed 
      shortly after with descriptions of their in vivo diversity and distribution by 
      Derek Hart, we are still continuing to progressively elucidate the spectrum of 
      DCs present in various anatomical compartments. With the power of 
      high-dimensional approaches such as single-cell sequencing and multiparameter 
      cytometry, recent studies have shed new light on the identities and functions of 
      DC subtypes. Notable examples include the reclassification of plasmacytoid DCs as 
      purely interferon-producing cells and re-evaluation of intestinal conventional 
      DCs and macrophages as derived from monocyte precursors. Collectively, these 
      observations have changed how we view these cells not only in steady-state 
      immunity but also during disease and infection. In this review, we will discuss 
      the current landscape of DCs and their ontogeny, and how this influences our 
      understanding of their roles during HIV infection.
FAU - Rhodes, Jake William
AU  - Rhodes JW
AD  - Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, 
      NSW, Australia.
AD  - Sydney Medical School, The University of Sydney, Sydney, NSW, Australia.
FAU - Tong, Orion
AU  - Tong O
AD  - Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, 
      NSW, Australia.
FAU - Harman, Andrew Nicholas
AU  - Harman AN
AD  - Centre for Virus Research, The Westmead Institute for Medical Research, Sydney, 
      NSW, Australia.
AD  - Discipline of Applied Medical Sciences, School of Medical Sciences, The 
      University of Sydney, Sydney, NSW, Australia.
FAU - Turville, Stuart Grant
AU  - Turville SG
AD  - University of New South Wales, Sydney, NSW, Australia.
AD  - Kirby Institute, Kensington, NSW, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20190516
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biological Ontologies
MH  - Biomarkers
MH  - Dendritic Cells/*classification/*immunology/metabolism
MH  - HIV/*immunology
MH  - HIV Infections/*immunology/metabolism/*virology
MH  - Host-Pathogen Interactions/*immunology
MH  - Humans
MH  - Immunophenotyping
MH  - Organ Specificity
MH  - Phenotype
PMC - PMC6532592
OTO - NOTNLM
OT  - HIV
OT  - dendritic cells
OT  - in trans
OT  - myeloid
OT  - plasmacytoid
EDAT- 2019/06/04 06:00
MHDA- 2020/09/10 06:00
PMCR- 2019/01/01
CRDT- 2019/06/04 06:00
PHST- 2019/03/08 00:00 [received]
PHST- 2019/04/29 00:00 [accepted]
PHST- 2019/06/04 06:00 [entrez]
PHST- 2019/06/04 06:00 [pubmed]
PHST- 2020/09/10 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2019.01088 [doi]
PST - epublish
SO  - Front Immunol. 2019 May 16;10:1088. doi: 10.3389/fimmu.2019.01088. eCollection 
      2019.