PMID- 31156785
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2008-3866 (Print)
IS  - 2008-3874 (Electronic)
IS  - 2008-3866 (Linking)
VI  - 22
IP  - 3
DP  - 2019 Mar
TI  - The effect of alpha linolenic acid on tracheal responsiveness, lung inflammation, 
      and immune markers in sensitized rats.
PG  - 255-261
LID - 10.22038/ijbms.2019.27381.6684 [doi]
AB  - OBJECTIVES: The effects of alpha linolenic acid (ALA) on tracheal responsiveness 
      (TR), total protein (TP), phospholipase A2 (PLA2), immunoglobulin E (IgE), 
      interleukin 4 (IL-4), interferon gamma (INF-gamma) level and INF-gamma/IL4 ratio in 
      bronchoalveolar lavage fluid (BALF) of sensitized rats were examined. MATERIALS 
      AND METHODS: TR to methacholine and ovalbumin (OA), BALF levels of TP, PLA2 and 
      IgE as well as IL-4, INF-gamma and INF-gamma/IL4 ratio were measured in control group 
      (non-sensitized, group C), sensitized rats to OA (group S), S groups treated with 
      two concentrations of ALA and dexamethasone group. RESULTS: TR to methacholine 
      and OA, BALF levels of TP, PLA2, IgE and IL-4 were significantly increased but 
      BALF level of INF-gamma and INF-gamma/IL4 ratio decreased in group S compared to group C 
      (P<0.001 for all cases). Treated S groups with dexamethasone and both 
      concentrations of ALA lead to significant decrease in TR to methacholine and OA, 
      BALF levels of TP, PLA2, IgE and IL-4 compared to group S (P<0.001 for all case). 
      The effects of all concentrations of ALA on INF-gamma, IL-4 and INF-gamma/IL4 ratio and 
      also the effect of its highest concentration on TP and IgE level were 
      significantly higher than dexamethasone treatment (P<0.001 for all cases). 
      CONCLUSION: Results showed an immune modulatory effect of the ALA that increased 
      INF-gamma, INF-gamma/IL4 ratio (as an index of Th1/Th2) and decreased IL-4 in sensitized 
      rats. ALA also showed preventive effect on inflammatory markers and tracheal 
      responsiveness in sensitized animals comparable to the effect of dexamethasone.
FAU - Kaveh, Mahsa
AU  - Kaveh M
AD  - Department of Biology, Science and Research Branch, Islamic Azad University, 
      Tehran, Iran.
FAU - Eftekhar, Naeima
AU  - Eftekhar N
AD  - Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Iran.
FAU - Boskabady, Mohammad Hossein
AU  - Boskabady MH
AD  - Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
AD  - Department of Physiology, School of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Iran J Basic Med Sci
JT  - Iranian journal of basic medical sciences
JID - 101517966
PMC - PMC6528709
OTO - NOTNLM
OT  - Alpha linolenic acid
OT  - Asthma
OT  - Inflammatory markers
OT  - Sensitized rats
OT  - Th1/Th2 balance
OT  - Tracheal responsiveness
COIS- The authors have no conflict of interests to declare.
EDAT- 2019/06/04 06:00
MHDA- 2019/06/04 06:01
PMCR- 2019/03/01
CRDT- 2019/06/04 06:00
PHST- 2019/06/04 06:00 [entrez]
PHST- 2019/06/04 06:00 [pubmed]
PHST- 2019/06/04 06:01 [medline]
PHST- 2019/03/01 00:00 [pmc-release]
AID - 10.22038/ijbms.2019.27381.6684 [doi]
PST - ppublish
SO  - Iran J Basic Med Sci. 2019 Mar;22(3):255-261. doi: 
      10.22038/ijbms.2019.27381.6684.