PMID- 3115795
OWN - NLM
STAT- MEDLINE
DCOM- 19871112
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 139
IP  - 1
DP  - 1987 Jul 2
TI  - Sympatho-adrenomedullary system mediation of the bombesin-induced central 
      inhibition of gastric acid secretion.
PG  - 73-8
AB  - Possible mechanisms of the inhibitory effect of bombesin on gastric acid 
      secretion were examined in rats anesthetized with urethane. 
      Intracerebroventricular (i.c.v.) administration of bombesin (0.1-3 nmol) dose 
      dependently inhibited the increase in gastric acid secretion induced by both 
      intravenous (i.v.) administration of 2-deoxy-D-glucose 60 mg/kg and electrical 
      stimulation of the vagus nerve (1 mA, 0.5 ms, 3 Hz), but not increase due to i.v. 
      infusion of bethanechol (10 micrograms/kg per min). Such an inhibitory effect of 
      bombesin on the gastric response was markedly reduced by bilateral cutting of the 
      greater splanchnic nerves. The inhibitory effect of bombesin on gastric acid 
      secretion induced by stimulation of the vagus nerve was not modified either by 
      chemical sympathectomy with 6-hydroxydopamine or by bilateral adrenalectomy 
      alone. However, this inhibitory effect of bombesin was abolished under conditions 
      of combined chemical sympathectomy and adrenalectomy. These results suggest that 
      bombesin (i.c.v.) probably excites the sympatho-adrenomedullary system and thus 
      induces inhibition of gastric acid secretion. Furthermore, a dysfunction of the 
      sympathetic or of the adrenomedullary system may well be functionally compensated 
      for by the system with unaltered function.
FAU - Okuma, Y
AU  - Okuma Y
AD  - Department of Pharmacology, Kochi Medical School, Japan.
FAU - Yokotani, K
AU  - Yokotani K
FAU - Osumi, Y
AU  - Osumi Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Bethanechol Compounds)
RN  - 0 (Hydroxydopamines)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - 9G2MP84A8W (Deoxyglucose)
RN  - PX9AZU7QPK (Bombesin)
SB  - IM
MH  - Adrenal Medulla/*physiology
MH  - Animals
MH  - Bethanechol Compounds/pharmacology
MH  - Bombesin/*pharmacology
MH  - Deoxyglucose/pharmacology
MH  - Electric Stimulation
MH  - Gastric Acid/drug effects/*metabolism
MH  - Hydroxydopamines/pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Oxidopamine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Sympathectomy, Chemical
MH  - Sympathetic Nervous System/*physiology
MH  - Vagus Nerve/physiology
EDAT- 1987/07/02 00:00
MHDA- 1987/07/02 00:01
CRDT- 1987/07/02 00:00
PHST- 1987/07/02 00:00 [pubmed]
PHST- 1987/07/02 00:01 [medline]
PHST- 1987/07/02 00:00 [entrez]
AID - 0014-2999(87)90499-7 [pii]
AID - 10.1016/0014-2999(87)90499-7 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1987 Jul 2;139(1):73-8. doi: 10.1016/0014-2999(87)90499-7.