PMID- 31159395
OWN - NLM
STAT- MEDLINE
DCOM- 20191212
LR  - 20200225
IS  - 1648-9144 (Electronic)
IS  - 1010-660X (Print)
IS  - 1010-660X (Linking)
VI  - 55
IP  - 6
DP  - 2019 Jun 1
TI  - Immunoinformatics Based Study of T Cell Epitopes in Zea m 1 Pollen Allergen.
LID - 10.3390/medicina55060236 [doi]
LID - 236
AB  - Background and Objectives: Zea m 1 is a pollen allergen, which is present in 
      maize, is accountable for a type I hypersensitivity reaction in all over the 
      world. Several effective medications are available for the disorder with various 
      side effects. Design and verification of a peptide-based vaccine is a 
      state-of-art technology which is more cost effective than conventional drugs. 
      Materials and Methods: Using immunoinformatic methods, the T cell epitopes from 
      the whole structure of this allergenic protein can be predicted. Worldwide 
      conserved region study among the other pollen allergens has been performed for T 
      cell predicted epitopes by using a conservancy tool. This analysis will help to 
      identify completely conserved HLA (human leukocyte antigen) binding epitopes. 
      Lastly, molecular docking study and MHC-oligopeptide complex binding energy 
      calculation data are applied to determine the interacting amino acids and the 
      affinity of the epitopes to the class II MHCmolecule. Results: The study of 
      criteria-based analysis predicts the presence of two epitopes YVADDGDIV and 
      WRMDTAKAL on this pollen allergen. Conclusions: The T cell epitopes identified in 
      this study provide insight into a peptide-based vaccine for a type I 
      hypersensitivity reaction induced by Zea m 1 grass pollen allergenic protein.
FAU - Basu, Anamika
AU  - Basu A
AD  - Deptartment of Biochemistry, Gurudas College, Kolkata 70006, India. 
      basuanamikaami@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20190601
PL  - Switzerland
TA  - Medicina (Kaunas)
JT  - Medicina (Kaunas, Lithuania)
JID - 9425208
RN  - 0 (Allergens)
RN  - 0 (Epitopes, T-Lymphocyte)
SB  - IM
MH  - Allergens/adverse effects
MH  - Epitopes, T-Lymphocyte/*immunology
MH  - Humans
MH  - Immunization
MH  - Pollen/adverse effects/*immunology
MH  - Zea mays/*adverse effects/immunology
PMC - PMC6630604
OTO - NOTNLM
OT  - Zea m 1
OT  - molecular docking
OT  - peptide-based vaccine design
OT  - pollen allergens
OT  - type I hypersensitivity reaction
COIS- The author declares no conflict of interest.
EDAT- 2019/06/05 06:00
MHDA- 2019/12/18 06:00
PMCR- 2019/06/01
CRDT- 2019/06/05 06:00
PHST- 2019/01/01 00:00 [received]
PHST- 2019/05/27 00:00 [revised]
PHST- 2019/05/27 00:00 [accepted]
PHST- 2019/06/05 06:00 [entrez]
PHST- 2019/06/05 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/06/01 00:00 [pmc-release]
AID - medicina55060236 [pii]
AID - medicina-55-00236 [pii]
AID - 10.3390/medicina55060236 [doi]
PST - epublish
SO  - Medicina (Kaunas). 2019 Jun 1;55(6):236. doi: 10.3390/medicina55060236.