PMID- 31159427
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231012
IS  - 2072-666X (Print)
IS  - 2072-666X (Electronic)
IS  - 2072-666X (Linking)
VI  - 10
IP  - 6
DP  - 2019 Jun 1
TI  - Magnetic Micromachine Using Nickel Nanoparticles for Propelling and Releasing in 
      Indirect Assembly of Cell-Laden Micromodules.
LID - 10.3390/mi10060370 [doi]
LID - 370
AB  - Magnetic micromachines as wireless end-effectors have been widely applied for 
      drug discovery and regenerative medicine. Yet, the magnetic assembly of 
      arbitrarily shaped cellular microstructures with high efficiency and flexibility 
      still remains a big challenge. Here, a novel clamp-shape micromachine using 
      magnetic nanoparticles was developed for the indirect untethered bioassembly. 
      With a multi-layer template, the nickel nanoparticles were mixed with 
      polydimethylsiloxane (PDMS) for mold replication of the micromachine with a 
      high-resolution and permeability. To actuate the micromachine with a high 
      flexibility and large scalable operation range, a multi-pole electromagnetic 
      system was set up to generate a three-dimensional magnetic field in a large 
      workspace. Through designing a series of flexible translations and rotations with 
      a velocity of 15mm/s and 3 Hz, the micromachine realized the propel-and-throw 
      strategy to overcome the inevitable adhesion during bioassembly. The hydrogel 
      microstructures loaded with different types of cells or the bioactive materials 
      were effectively assembled into microtissues with reconfigurable shape and 
      composition. The results indicate that indirect magnetic manipulation can perform 
      an efficient and versatile bioassembly of cellular micromodules, which is 
      promising for drug trials and modular tissue engineering.
FAU - Li, Jianing
AU  - Li J
AD  - Intelligent Robotics Institute, School of Mechatronical Engineering, Beijing 
      Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 
      100081, China. 2120170179@bit.edu.cn.
FAU - Wang, Huaping
AU  - Wang H
AUID- ORCID: 0000-0001-8440-3402
AD  - Intelligent Robotics Institute, School of Mechatronical Engineering, Beijing 
      Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 
      100081, China. wanghuaping@bit.edu.cn.
FAU - Cui, Juan
AU  - Cui J
AD  - Intelligent Robotics Institute, School of Mechatronical Engineering, Beijing 
      Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 
      100081, China. cuijuan2016@bit.edu.cn.
FAU - Shi, Qing
AU  - Shi Q
AD  - Intelligent Robotics Institute, School of Mechatronical Engineering, Beijing 
      Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 
      100081, China. shiqing@bit.edu.cn.
FAU - Zheng, Zhiqiang
AU  - Zheng Z
AD  - Intelligent Robotics Institute, School of Mechatronical Engineering, Beijing 
      Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 
      100081, China. zzqyouyou@sina.com.
FAU - Sun, Tao
AU  - Sun T
AD  - Intelligent Robotics Institute, School of Mechatronical Engineering, Beijing 
      Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 
      100081, China. 3120120061@bit.edu.cn.
FAU - Huang, Qiang
AU  - Huang Q
AD  - Intelligent Robotics Institute, School of Mechatronical Engineering, Beijing 
      Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 
      100081, China. qhuang@bit.edu.cn.
FAU - Fukuda, Toshio
AU  - Fukuda T
AD  - Intelligent Robotics Institute, School of Mechatronical Engineering, Beijing 
      Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 
      100081, China. tofukuda@nifty.com.
LA  - eng
GR  - Z181100003118007/Beijing Municipal Science and Technology Commission/
GR  - 2017YFE0117000./National Key R&D Program of China/
PT  - Journal Article
DEP - 20190601
PL  - Switzerland
TA  - Micromachines (Basel)
JT  - Micromachines
JID - 101640903
PMC - PMC6631220
OTO - NOTNLM
OT  - bioassembly
OT  - magnetic manipulation
OT  - magnetic nanoparticles
OT  - tissue engineering
COIS- The authors declare no conflict of interest.
EDAT- 2019/06/05 06:00
MHDA- 2019/06/05 06:01
PMCR- 2019/06/01
CRDT- 2019/06/05 06:00
PHST- 2019/05/06 00:00 [received]
PHST- 2019/05/23 00:00 [revised]
PHST- 2019/05/28 00:00 [accepted]
PHST- 2019/06/05 06:00 [entrez]
PHST- 2019/06/05 06:00 [pubmed]
PHST- 2019/06/05 06:01 [medline]
PHST- 2019/06/01 00:00 [pmc-release]
AID - mi10060370 [pii]
AID - micromachines-10-00370 [pii]
AID - 10.3390/mi10060370 [doi]
PST - epublish
SO  - Micromachines (Basel). 2019 Jun 1;10(6):370. doi: 10.3390/mi10060370.