PMID- 31159641
OWN - NLM
STAT- MEDLINE
DCOM- 20200227
LR  - 20200227
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Linking)
VI  - 161
IP  - 4
DP  - 2019 Oct
TI  - Understanding the Minimal Clinically Important Difference (MCID) of 
      Patient-Reported Outcome Measures.
PG  - 551-560
LID - 10.1177/0194599819852604 [doi]
AB  - OBJECTIVE: The minimal clinically important difference (MCID) of a 
      patient-reported outcome measure (PROM) represents a threshold value of change in 
      PROM score deemed to have an implication in clinical management. The MCID is 
      frequently used to interpret the significance of results from clinical studies 
      that use PROMs. However, an understanding of the many caveats of the MCID, as 
      well as its strengths and limitations, is necessary. The objective of this 
      article is to provide a review of the calculation, interpretation, and caveats of 
      MCID. DATA SOURCES: MEDLINE and PubMed Central. REVIEW METHODS: Literature 
      search-including primary studies, review articles, and consensus 
      statements-pertinent to the objectives of this review using PubMed. CONCLUSIONS: 
      The MCID of a PROM may vary depending on the patients and clinical context in 
      which the PROM is given. The primary approaches for calculating MCID are 
      distribution-based and anchor-based methods. Each methodology has strengths and 
      limitations, and the ideal determination of a PROM MCID includes synthesis of 
      results from both approaches. The MCID of a PROM is also not perfect in detecting 
      patients experiencing a clinically important improvement, and this is reflected 
      in its accuracy (eg, sensitivity and specificity). IMPLICATIONS FOR PRACTICE: 
      Interpretation or application of MCID requires consideration of all caveats 
      underlying the MCID, including the patients in whom it was derived, the 
      limitations of the methodologies used to calculate it, and its accuracy for 
      identifying patients who have experienced clinically significant improvement.
FAU - Sedaghat, Ahmad R
AU  - Sedaghat AR
AD  - Department of Otolaryngology-Head & Neck Surgery, University of Cincinnati 
      College of Medicine, Cincinnati, Ohio, USA.
LA  - eng
PT  - Journal Article
DEP - 20190604
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
SB  - IM
MH  - Humans
MH  - Mathematical Concepts
MH  - *Minimal Clinically Important Difference
MH  - *Patient Reported Outcome Measures
MH  - Statistics as Topic/*methods
OTO - NOTNLM
OT  - MCID
OT  - minimal clinically significant difference
OT  - outcomes
OT  - quality of life
EDAT- 2019/06/05 06:00
MHDA- 2020/02/28 06:00
CRDT- 2019/06/05 06:00
PHST- 2019/06/05 06:00 [pubmed]
PHST- 2020/02/28 06:00 [medline]
PHST- 2019/06/05 06:00 [entrez]
AID - 10.1177/0194599819852604 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2019 Oct;161(4):551-560. doi: 
      10.1177/0194599819852604. Epub 2019 Jun 4.