PMID- 31160823
OWN - NLM
STAT- MEDLINE
DCOM- 20200121
LR  - 20220417
IS  - 2058-5276 (Electronic)
IS  - 2058-5276 (Linking)
VI  - 4
IP  - 9
DP  - 2019 Sep
TI  - Anti-Siglec-1 antibodies block Ebola viral uptake and decrease cytoplasmic viral 
      entry.
PG  - 1558-1570
LID - 10.1038/s41564-019-0453-2 [doi]
AB  - Several Ebola viruses cause outbreaks of lethal haemorrhagic fever in humans, but 
      developing therapies tackle only Zaire Ebola virus. Dendritic cells (DCs) are 
      targets of this infection in vivo. Here, we found that Ebola virus entry into 
      activated DCs requires the sialic acid-binding Ig-like lectin 1 (Siglec-1/CD169), 
      which recognizes sialylated gangliosides anchored to viral membranes. Blockage of 
      the Siglec-1 receptor by anti-Siglec-1 monoclonal antibodies halted Ebola viral 
      uptake and cytoplasmic entry, offering cross-protection against other 
      ganglioside-containing viruses such as human immunodeficiency virus type 1.
FAU - Perez-Zsolt, Daniel
AU  - Perez-Zsolt D
AD  - IrsiCaixa AIDS Research Institute, Badalona, Spain.
AD  - Universitat Autonoma de Barcelona, Barcelona, Spain.
FAU - Erkizia, Itziar
AU  - Erkizia I
AD  - IrsiCaixa AIDS Research Institute, Badalona, Spain.
FAU - Pino, Maria
AU  - Pino M
AD  - IrsiCaixa AIDS Research Institute, Badalona, Spain.
FAU - Garcia-Gallo, Monica
AU  - Garcia-Gallo M
AD  - Protein Tools Unit and Department of Immunology and Oncology, Spanish National 
      Center for Biotechnology, Consejo Superior de Investigaciones Cientificas, 
      Madrid, Spain.
FAU - Martin, Maria Teresa
AU  - Martin MT
AD  - Protein Tools Unit and Department of Immunology and Oncology, Spanish National 
      Center for Biotechnology, Consejo Superior de Investigaciones Cientificas, 
      Madrid, Spain.
FAU - Benet, Susana
AU  - Benet S
AD  - IrsiCaixa AIDS Research Institute, Badalona, Spain.
AD  - Universitat Autonoma de Barcelona, Barcelona, Spain.
FAU - Chojnacki, Jakub
AU  - Chojnacki J
AUID- ORCID: 0000-0002-4457-8096
AD  - IrsiCaixa AIDS Research Institute, Badalona, Spain.
FAU - Fernandez-Figueras, Maria Teresa
AU  - Fernandez-Figueras MT
AD  - Department of Pathology, Hospital Universitari General de Catalunya-Grupo Quiron 
      Salud, Barcelona, Spain.
AD  - Universitat Internacional de Catalunya, Barcelona, Spain.
AD  - Institut d'Investigacio en Ciencies de la Salut Germans Trias i Pujol, Badalona, 
      Spain.
FAU - Guerrero, Dolores
AU  - Guerrero D
AD  - Otorhinolaryngology Department, Hospital Universitari Germans Trias i Pujol, 
      Badalona, Spain.
FAU - Urrea, Victor
AU  - Urrea V
AD  - IrsiCaixa AIDS Research Institute, Badalona, Spain.
FAU - Muniz-Trabudua, Xabier
AU  - Muniz-Trabudua X
AD  - IrsiCaixa AIDS Research Institute, Badalona, Spain.
AD  - Universitat Autonoma de Barcelona, Barcelona, Spain.
FAU - Kremer, Leonor
AU  - Kremer L
AUID- ORCID: 0000-0002-2235-2010
AD  - Protein Tools Unit and Department of Immunology and Oncology, Spanish National 
      Center for Biotechnology, Consejo Superior de Investigaciones Cientificas, 
      Madrid, Spain.
FAU - Martinez-Picado, Javier
AU  - Martinez-Picado J
AUID- ORCID: 0000-0002-4916-2129
AD  - IrsiCaixa AIDS Research Institute, Badalona, Spain. jmpicado@irsicaixa.es.
AD  - University of Vic-Central University of Catalonia, Vic, Spain. 
      jmpicado@irsicaixa.es.
AD  - Catalan Institution for Research and Advanced Studies, Barcelona, Spain. 
      jmpicado@irsicaixa.es.
FAU - Izquierdo-Useros, Nuria
AU  - Izquierdo-Useros N
AUID- ORCID: 0000-0002-1039-1821
AD  - IrsiCaixa AIDS Research Institute, Badalona, Spain. nizquierdo@irsicaixa.es.
AD  - Institut d'Investigacio en Ciencies de la Salut Germans Trias i Pujol, Badalona, 
      Spain. nizquierdo@irsicaixa.es.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190603
PL  - England
TA  - Nat Microbiol
JT  - Nature microbiology
JID - 101674869
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Gangliosides)
RN  - 0 (Interferon-alpha)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (SIGLEC1 protein, human)
RN  - 0 (Sialic Acid Binding Ig-like Lectin 1)
SB  - IM
MH  - Antibodies, Monoclonal/*pharmacology
MH  - Cytoplasm/*virology
MH  - Dendritic Cells/drug effects/metabolism/virology
MH  - Ebolavirus/*physiology
MH  - Gangliosides/metabolism
MH  - HIV-1/physiology
MH  - Hemorrhagic Fever, Ebola/virology
MH  - Host-Pathogen Interactions/drug effects
MH  - Humans
MH  - Interferon-alpha/pharmacology
MH  - Lipopolysaccharides/pharmacology
MH  - Sialic Acid Binding Ig-like Lectin 1/*antagonists & 
      inhibitors/immunology/metabolism
MH  - Virion/metabolism
MH  - Virus Attachment/*drug effects
MH  - Virus Internalization/*drug effects
EDAT- 2019/06/05 06:00
MHDA- 2020/01/22 06:00
CRDT- 2019/06/05 06:00
PHST- 2018/07/12 00:00 [received]
PHST- 2019/04/11 00:00 [accepted]
PHST- 2019/06/05 06:00 [pubmed]
PHST- 2020/01/22 06:00 [medline]
PHST- 2019/06/05 06:00 [entrez]
AID - 10.1038/s41564-019-0453-2 [pii]
AID - 10.1038/s41564-019-0453-2 [doi]
PST - ppublish
SO  - Nat Microbiol. 2019 Sep;4(9):1558-1570. doi: 10.1038/s41564-019-0453-2. Epub 2019 
      Jun 3.