PMID- 3116183
OWN - NLM
STAT- MEDLINE
DCOM- 19871110
LR  - 20041117
IS  - 0887-2570 (Print)
IS  - 0887-2570 (Linking)
VI  - 6
IP  - 3
DP  - 1987 May-Jun
TI  - Human leukocyte antigen compatibility in heart-lung transplantation.
PG  - 162-6
AB  - The relationship of heart-lung allograft-related death and obliterative 
      bronchiolitis (OB) to human leukocyte antigen (HLA) matching was studied in 40 
      consecutive heart-lung transplant patients operated on between March 1981 and 
      September 1986. Mismatch was defined as an antigen present in the donor but not 
      in the recipient. Patients with only one antigen identified at a given locus were 
      presumed to be homozygous for that antigen. The results were obtained from the 
      patients who survived more than 3 months after surgery. The patients with zero to 
      one mismatches in the HLA locus A (10 patients) had a tendency toward less OB, 
      less severe OB, and fewer deaths from OB than the patients (15) with two 
      mismatches in HLA locus A. However, only graded OB (1, mild; 2, moderate; 3, 
      severe) was significantly different (p = 0.05) in these groups. There was one 
      patient with no A locus mismatches; she survived 62 months, and no OB was found 
      at her autopsy. This limited experience suggests that HLA-A locus match may have 
      a salutary effect on long-term results and that OB may be at least partly a 
      result of chronic rejection.
FAU - Harjula, A L
AU  - Harjula AL
AD  - Department of Cardiovascular Surgery, Stanford University School of Medicine, CA 
      94305.
FAU - Baldwin, J C
AU  - Baldwin JC
FAU - Glanville, A R
AU  - Glanville AR
FAU - Tazelaar, H
AU  - Tazelaar H
FAU - Oyer, P E
AU  - Oyer PE
FAU - Stinson, E B
AU  - Stinson EB
FAU - Shumway, N E
AU  - Shumway NE
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Heart Transplant
JT  - The Journal of heart transplantation
JID - 8604172
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Bronchiolitis Obliterans/etiology
MH  - Female
MH  - HLA Antigens/*analysis
MH  - HLA-A Antigens
MH  - *Heart Transplantation
MH  - *Heart-Lung Transplantation
MH  - *Histocompatibility
MH  - Humans
MH  - Leukocytes/*immunology
MH  - *Lung Transplantation
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications
EDAT- 1987/05/01 00:00
MHDA- 1987/05/01 00:01
CRDT- 1987/05/01 00:00
PHST- 1987/05/01 00:00 [pubmed]
PHST- 1987/05/01 00:01 [medline]
PHST- 1987/05/01 00:00 [entrez]
PST - ppublish
SO  - J Heart Transplant. 1987 May-Jun;6(3):162-6.