PMID- 31164866
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200225
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 10
DP  - 2019
TI  - Central Mechanism Controlling Pubertal Onset in Mammals: A Triggering Role of 
      Kisspeptin.
PG  - 312
LID - 10.3389/fendo.2019.00312 [doi]
LID - 312
AB  - Pubertal onset is thought to be timed by an increase in pulsatile 
      gonadotropin-releasing hormone (GnRH)/gonadotropin secretion in mammals. The 
      underlying mechanism of pubertal onset in mammals is still an open question. 
      Evidence accumulated in the last 15 years suggests that kisspeptin/neurokinin 
      B/dynorphin A (KNDy) neurons in the hypothalamic arcuate nucleus play a key role 
      in pubertal onset by triggering pulsatile GnRH/gonadotropin secretin in mammals. 
      Specifically, KNDy neurons are now considered a part of GnRH pulse generator, in 
      which neurokinin B facilitates and dynorphin A inhibits, the synchronized 
      discharge of KNDy neurons in autocrine and/or paracrine manners. Kisspeptin 
      serves as a potent secretagogue of GnRH secretion and thus its release is 
      fundamental to pubertal increase in GnRH/gonadotropin secretion in mammals. 
      Proposed mechanisms inhibiting Kiss1 (kisspeptin gene) expression during 
      childhood to juvenile varies from species to species: we envisage that negative 
      feedback action of estrogen plays a key role in the inhibition of Kiss1 
      expression in KNDy neurons in rodents and sheep, whereas estrogen-independent 
      inhibition of kisspeptin secretion by gamma-amino butyric acid or neuropeptide Y are 
      suggested to be responsible for the pre-pubertal suppression of GnRH/gonadotropin 
      secretion in primates. Taken together, the timing of pubertal onset is postulated 
      to be controlled by upstream regulators for kisspeptin biosynthesis and secretion 
      in mammals.
FAU - Uenoyama, Yoshihisa
AU  - Uenoyama Y
AD  - Laboratory of Animal Reproduction, Graduate School of Bioagricultural Sciences, 
      Nagoya University, Nagoya, Japan.
FAU - Inoue, Naoko
AU  - Inoue N
AD  - Laboratory of Animal Reproduction, Graduate School of Bioagricultural Sciences, 
      Nagoya University, Nagoya, Japan.
FAU - Nakamura, Sho
AU  - Nakamura S
AD  - Faculty of Veterinary Medicine, Okayama University of Science, Imabari, Japan.
FAU - Tsukamura, Hiroko
AU  - Tsukamura H
AD  - Laboratory of Animal Reproduction, Graduate School of Bioagricultural Sciences, 
      Nagoya University, Nagoya, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190521
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
PMC - PMC6536648
OTO - NOTNLM
OT  - GnRH pulse generator
OT  - KNDy
OT  - dynorphin A
OT  - gonadotropin-releasing hormone (GnRH)
OT  - kisspeptin
OT  - neurokinin B
OT  - puberty
EDAT- 2019/06/06 06:00
MHDA- 2019/06/06 06:01
PMCR- 2019/01/01
CRDT- 2019/06/06 06:00
PHST- 2018/12/17 00:00 [received]
PHST- 2019/04/30 00:00 [accepted]
PHST- 2019/06/06 06:00 [entrez]
PHST- 2019/06/06 06:00 [pubmed]
PHST- 2019/06/06 06:01 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2019.00312 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2019 May 21;10:312. doi: 10.3389/fendo.2019.00312. 
      eCollection 2019.