PMID- 31165582
OWN - NLM
STAT- MEDLINE
DCOM- 20200313
LR  - 20240418
IS  - 2162-3279 (Electronic)
VI  - 9
IP  - 7
DP  - 2019 Jul
TI  - Disruptions of the olfactory and default mode networks in Alzheimer's disease.
PG  - e01296
LID - 10.1002/brb3.1296 [doi]
LID - e01296
AB  - INTRODUCTION: Olfactory deficits are prevalent in early Alzheimer's disease (AD) 
      and are predictive of progressive memory loss and dementia. However, direct 
      neural evidence to relate AD neurodegeneration to deficits in olfaction and 
      memory is limited. METHODS: We combined the University of Pennsylvania Smell 
      Identification Test (UPSIT) with olfactory functional magnetic resonance imaging 
      (fMRI) to investigate links between neurodegeneration, the olfactory network (ON) 
      and the default mode network (DMN) in AD. RESULTS: Behaviorally, olfactory and 
      memory scores showed a strong positive correlation in the study cohorts. During 
      olfactory fMRI, the ON showed reduced task-related activation and the DMN showed 
      reduced task-related suppression in mild cognitive impairment (MCI) and AD 
      subjects compared to age-matched cognitively normal subjects. CONCLUSIONS: The 
      results provide in vivo evidence for selective vulnerability of ON and DMN in AD 
      and significantly improves the viable clinical applications of olfactory testing. 
      A network-based approach, focusing on network integrity rather than focal 
      pathology, seems beneficial to olfactory prediction of dementia in AD.
CI  - (c) 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
FAU - Lu, Jiaming
AU  - Lu J
AD  - Department of Radiology, The Pennsylvania State University College of Medicine, 
      Hershey, Pennsylvania.
AD  - Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
FAU - Yang, Qing X
AU  - Yang QX
AD  - Department of Radiology, The Pennsylvania State University College of Medicine, 
      Hershey, Pennsylvania.
AD  - Department of Neurosurgery, The Pennsylvania State University College of 
      Medicine, Hershey, Pennsylvania.
FAU - Zhang, Han
AU  - Zhang H
AD  - Department of Radiology and Biomedical Research Imaging Center (BRIC), University 
      of North Carolina at Chapel Hill, Chapel Hill, NC.
FAU - Eslinger, Paul J
AU  - Eslinger PJ
AD  - Department of Radiology, The Pennsylvania State University College of Medicine, 
      Hershey, Pennsylvania.
AD  - Department of Neurology, The Pennsylvania State University College of Medicine, 
      Hershey, Pennsylvania.
FAU - Zhang, Xin
AU  - Zhang X
AD  - Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
FAU - Wu, Sichu
AU  - Wu S
AD  - Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
FAU - Zhang, Bing
AU  - Zhang B
AD  - Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
FAU - Zhu, Bin
AU  - Zhu B
AD  - Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
FAU - Karunanayaka, Prasanna R
AU  - Karunanayaka PR
AUID- ORCID: 0000-0002-1558-8981
AD  - Department of Radiology, The Pennsylvania State University College of Medicine, 
      Hershey, Pennsylvania.
LA  - eng
GR  - R01 AG027771/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190604
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
SB  - IM
MH  - Aged
MH  - *Alzheimer Disease/physiopathology/psychology
MH  - Cognition/physiology
MH  - Correlation of Data
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Memory/physiology
MH  - *Nerve Net/diagnostic imaging/physiopathology
MH  - *Olfactory Cortex/diagnostic imaging/physiopathology
MH  - Olfactory Perception/physiology
PMC - PMC6625464
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - default mode network
OT  - mild cognitive impairment
OT  - olfactory fMRI
OT  - olfactory network
COIS- The authors report no competing interests.
EDAT- 2019/06/06 06:00
MHDA- 2020/03/14 06:00
PMCR- 2019/06/04
CRDT- 2019/06/06 06:00
PHST- 2019/01/06 00:00 [received]
PHST- 2019/03/28 00:00 [revised]
PHST- 2019/04/03 00:00 [accepted]
PHST- 2019/06/06 06:00 [pubmed]
PHST- 2020/03/14 06:00 [medline]
PHST- 2019/06/06 06:00 [entrez]
PHST- 2019/06/04 00:00 [pmc-release]
AID - BRB31296 [pii]
AID - 10.1002/brb3.1296 [doi]
PST - ppublish
SO  - Brain Behav. 2019 Jul;9(7):e01296. doi: 10.1002/brb3.1296. Epub 2019 Jun 4.