PMID- 31166544
OWN - NLM
STAT- MEDLINE
DCOM- 20200306
LR  - 20200309
IS  - 1809-452X (Electronic)
IS  - 1516-4446 (Print)
IS  - 1516-4446 (Linking)
VI  - 42
IP  - 1
DP  - 2020 Jan-Feb
TI  - Schneider's first-rank symptoms as predictors of remission in antipsychotic-naive 
      first-episode psychosis.
PG  - 22-26
LID - 10.1590/1516-4446-2018-0237 [doi]
AB  - OBJECTIVE: German psychiatrist Kurt Schneider proposed the concept of first-rank 
      symptoms (FRS) of schizophrenia in 1959. However, their relevance for diagnosis 
      and prediction of treatment response are still unclear. Most studies have 
      investigated FRS in chronic or medicated patients. The present study sought to 
      evaluate whether FRS predict remission, response, or improvement in functionality 
      in antipsychotic-naive first-episode psychosis. METHODS: Follow-up study of 100 
      patients at first episode of psychosis (FEP), with no previous treatment, 
      assessed at baseline and after 2 months of treatment. The participants were 
      evaluated with the standardized Positive and Negative Syndrome Scale (PANSS) and 
      Global Assessment of Functioning (GAF) and for presence of FRS. RESULTS: Logistic 
      regression analysis showed that, in this sample, up to three individual FRS 
      predicted remission: voices arguing, voices commenting on one's actions, and 
      thought broadcasting. CONCLUSION: Specific FRS may predict remission after 
      treatment in FEP patients. This finding could give new importance to Kurt 
      Schneider's classic work by contributing to future updates of diagnostic 
      protocols and improving estimation of prognosis.
FAU - Malinowski, Fernando R
AU  - Malinowski FR
AUID- ORCID: 0000-0002-7452-489X
AD  - Laboratorio Interdisciplinar de Neurociencias Clinicas (LiNC), Departamento de 
      Psiquiatria, Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.
AD  - Programa de Esquizofrenia (PROESQ), Departamento de Psiquiatria, UNIFESP, Sao 
      Paulo, SP, Brazil.
FAU - Tasso, Brazilio de C
AU  - Tasso BC
AD  - Central Hospital, Centro de Atencao Integrada a Saude Mental (CAISM), Complexo 
      Hospitalar do Juquery, Franco da Rocha, SP, Brazil.
FAU - Ortiz, Bruno B
AU  - Ortiz BB
AD  - Laboratorio Interdisciplinar de Neurociencias Clinicas (LiNC), Departamento de 
      Psiquiatria, Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.
AD  - Programa de Esquizofrenia (PROESQ), Departamento de Psiquiatria, UNIFESP, Sao 
      Paulo, SP, Brazil.
FAU - Higuchi, Cinthia H
AU  - Higuchi CH
AD  - Laboratorio Interdisciplinar de Neurociencias Clinicas (LiNC), Departamento de 
      Psiquiatria, Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.
FAU - Noto, Cristiano
AU  - Noto C
AUID- ORCID: 0000-0002-2706-9118
AD  - Laboratorio Interdisciplinar de Neurociencias Clinicas (LiNC), Departamento de 
      Psiquiatria, Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.
AD  - Programa de Esquizofrenia (PROESQ), Departamento de Psiquiatria, UNIFESP, Sao 
      Paulo, SP, Brazil.
FAU - Belangero, Sintia I
AU  - Belangero SI
AD  - Laboratorio Interdisciplinar de Neurociencias Clinicas (LiNC), Departamento de 
      Psiquiatria, Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.
FAU - Bressan, Rodrigo A
AU  - Bressan RA
AD  - Laboratorio Interdisciplinar de Neurociencias Clinicas (LiNC), Departamento de 
      Psiquiatria, Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.
FAU - Gadelha, Ary
AU  - Gadelha A
AD  - Laboratorio Interdisciplinar de Neurociencias Clinicas (LiNC), Departamento de 
      Psiquiatria, Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, SP, Brazil.
AD  - Programa de Esquizofrenia (PROESQ), Departamento de Psiquiatria, UNIFESP, Sao 
      Paulo, SP, Brazil.
FAU - Cordeiro, Quirino
AU  - Cordeiro Q
AD  - Departamento de Psiquiatria, Irmandade da Santa Casa de Misericordia de Sao Paulo 
      (ISCMSP), Sao Paulo, SP, Brazil.
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Braz J Psychiatry
JT  - Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
JID - 100895975
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/*therapeutic use
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Predictive Value of Tests
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/*diagnosis/*drug therapy
MH  - Reference Values
MH  - Remission Induction
MH  - Schizophrenia/*diagnosis/*drug therapy
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC6986488
COIS- The authors report no conflicts of interest.
EDAT- 2019/06/06 06:00
MHDA- 2020/03/07 06:00
PMCR- 2019/05/30
CRDT- 2019/06/06 06:00
PHST- 2018/08/01 00:00 [received]
PHST- 2019/03/07 00:00 [accepted]
PHST- 2019/06/06 06:00 [pubmed]
PHST- 2020/03/07 06:00 [medline]
PHST- 2019/06/06 06:00 [entrez]
PHST- 2019/05/30 00:00 [pmc-release]
AID - S1516-44462019005009101 [pii]
AID - 10.1590/1516-4446-2018-0237 [doi]
PST - ppublish
SO  - Braz J Psychiatry. 2020 Jan-Feb;42(1):22-26. doi: 10.1590/1516-4446-2018-0237.