PMID- 31167533
OWN - NLM
STAT- MEDLINE
DCOM- 20191007
LR  - 20191007
IS  - 0028-2685 (Print)
IS  - 0028-2685 (Linking)
VI  - 66
IP  - 5
DP  - 2019 Sep
TI  - Differential expression of sonic hedgehog in lung adenocarcinoma and lung 
      squamous cell carcinoma.
PG  - 839-846
LID - 181228N1002 [pii]
LID - 10.4149/neo_2018_181228N1002 [doi]
AB  - Overexpression of Sonic hedgehog (Shh) is associated with progression of several 
      cancers. The expression of Shh in non-small cell lung cancer (NSCLC) has been 
      reported with inconsistent results. Lung adenocarcinoma (LAC) and lung squamous 
      cell carcinoma (LSCC) are two major subtypes of NSCLC, which have different 
      genetic genotypes and clinical therapeutic options. The expression of Shh in 
      specimen of patients with NSCLC has yet to be comprehensively determined 
      according to histological subtypes. Shh expression level was determined in 167 
      NSCLC patients (56 LAC patients and 111 LSCC patients) by immunohistochemical 
      assay (IHC) and disease-free survival and overall survival of patients were 
      analyzed using the Kaplan-Meier method. Shh protein level in pleural effusion 
      from patients with pneumonia or pleural empyema, tuberculosis, LAC and LSCC was 
      measured with enzyme-linked immunoassay (ELISA). We found that Shh expression is 
      increased in tumor tissues from both LAC and LSCC patients compared with the 
      paired adjacent tissues, while Shh level is negatively correlated with tumor 
      differentiation only in LSCC, LSCC patients containing higher-Shh expression have 
      a poorer prognosis. Furthermore, Shh level is elevated in pleural effusion from 
      LSCC patients compared with that of parapneumonic and LAC pleural effusion. Shh 
      expression in tumor tissues or pleural effusion may represent a potential 
      diagnostic and prognostic marker of LSCC patients, pleural effusion Shh may 
      assist to distinguish between LAC and LSCC.
FAU - Xu, L
AU  - Xu L
AD  - Center for Experimental Medicine, The First Affiliated Hospital of Nanchang 
      University, Nanchang, China.
FAU - Xiong, H
AU  - Xiong H
AD  - Center for Experimental Medicine, The First Affiliated Hospital of Nanchang 
      University, Nanchang, China.
FAU - Shi, W
AU  - Shi W
AD  - Center for Experimental Medicine, The First Affiliated Hospital of Nanchang 
      University, Nanchang, China.
FAU - Zhou, F
AU  - Zhou F
AD  - Center for Experimental Medicine, The First Affiliated Hospital of Nanchang 
      University, Nanchang, China.
FAU - Zhang, M
AU  - Zhang M
AD  - Center for Experimental Medicine, The First Affiliated Hospital of Nanchang 
      University, Nanchang, China.
FAU - Hu, G
AU  - Hu G
AD  - Center for Experimental Medicine, The First Affiliated Hospital of Nanchang 
      University, Nanchang, China.
FAU - Mei, J
AU  - Mei J
AD  - Department of Pathology, The First Affiliated Hospital of Nanchang University, 
      Nanchang, China.
FAU - Luo, S
AU  - Luo S
AD  - Center for Experimental Medicine, The First Affiliated Hospital of Nanchang 
      University, Nanchang, China.
FAU - Chen, L
AU  - Chen L
AD  - Center for Experimental Medicine, The First Affiliated Hospital of Nanchang 
      University, Nanchang, China.
LA  - eng
PT  - Journal Article
DEP - 20190603
PL  - Slovakia
TA  - Neoplasma
JT  - Neoplasma
JID - 0377266
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Hedgehog Proteins)
RN  - 0 (SHH protein, human)
SB  - IM
MH  - Adenocarcinoma of Lung/*metabolism
MH  - Biomarkers, Tumor/metabolism
MH  - Carcinoma, Non-Small-Cell Lung/*metabolism
MH  - Carcinoma, Squamous Cell/*metabolism
MH  - Hedgehog Proteins/*metabolism
MH  - Humans
MH  - Lung Neoplasms/*metabolism
MH  - Prognosis
EDAT- 2019/06/07 06:00
MHDA- 2019/10/08 06:00
CRDT- 2019/06/07 06:00
PHST- 2018/12/28 00:00 [received]
PHST- 2019/03/20 00:00 [accepted]
PHST- 2019/06/07 06:00 [pubmed]
PHST- 2019/10/08 06:00 [medline]
PHST- 2019/06/07 06:00 [entrez]
AID - 181228N1002 [pii]
AID - 10.4149/neo_2018_181228N1002 [doi]
PST - ppublish
SO  - Neoplasma. 2019 Sep;66(5):839-846. doi: 10.4149/neo_2018_181228N1002. Epub 2019 
      Jun 3.