PMID- 31167563
OWN - NLM
STAT- MEDLINE
DCOM- 20200625
LR  - 20200625
IS  - 2042-6313 (Electronic)
IS  - 2042-6305 (Linking)
VI  - 8
IP  - 10
DP  - 2019 Jul
TI  - Risk of acute kidney injury in patients with HIV receiving proton pump 
      inhibitors.
PG  - 781-790
LID - 10.2217/cer-2019-0017 [doi]
AB  - Aims/patients & methods: To evaluate the risk of acute kidney injury (AKI) in 
      patients with HIV receiving proton pump inhibitors (PPI) a cohort study was 
      conducted utilizing the Veterans Affairs Informatics and Computing Infrastructure 
      (VINCI) database. Patients were followed from the index date until the earliest 
      date of AKI, 120 days or end of study period, or death. Statistical analyses 
      utilized a Cox proportional hazards model. Results: A total of 21,643 patients 
      (6000 PPI and 15,643 non-PPI) met all study criteria. The PPI cohort had twice 
      the risk of AKI compared with controls (2.12, hazard ratio: 1.46-3.1). 
      Conclusion: A nationwide cohort study supported the relationship of an increased 
      risk of AKI in patients receiving PPIs.
FAU - Sutton, S Scott
AU  - Sutton SS
AUID- ORCID: 0000-0002-3889-6178
AD  - Department of Clinical Pharmacy & Outcomes Sciences, South Carolina College of 
      Pharmacy, University of South Carolina, 715 Sumter Street (CLS 314b), Columbia, 
      SC 29208-0001, USA.
AD  - Dorn Research Institute, WJB Dorn Veterans Affairs Medical Center, Columbia, SC 
      29209, USA.
FAU - Magagnoli, Joseph
AU  - Magagnoli J
AD  - Dorn Research Institute, WJB Dorn Veterans Affairs Medical Center, Columbia, SC 
      29209, USA.
FAU - Cummings, Tammy H
AU  - Cummings TH
AD  - Dorn Research Institute, WJB Dorn Veterans Affairs Medical Center, Columbia, SC 
      29209, USA.
FAU - Hardin, James W
AU  - Hardin JW
AD  - Department of Epidemiology & Biostatistics, Biostatistics Division, University of 
      South Carolina, 1600 Hampton Street, Suite 507, Room 539, Columbia, SC 
      29208-3400, USA.
LA  - eng
PT  - Journal Article
DEP - 20190606
PL  - England
TA  - J Comp Eff Res
JT  - Journal of comparative effectiveness research
JID - 101577308
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Acute Kidney Injury/*complications
MH  - Cohort Studies
MH  - Databases, Factual
MH  - Female
MH  - Follow-Up Studies
MH  - HIV Infections/*complications/*drug therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Proton Pump Inhibitors/*therapeutic use
MH  - Retrospective Studies
MH  - Risk Factors
MH  - United States
MH  - Veterans/statistics & numerical data
OTO - NOTNLM
OT  - HIV
OT  - acute kidney injury
OT  - proton pump inhibitors
EDAT- 2019/06/07 06:00
MHDA- 2020/06/26 06:00
CRDT- 2019/06/07 06:00
PHST- 2019/06/07 06:00 [pubmed]
PHST- 2020/06/26 06:00 [medline]
PHST- 2019/06/07 06:00 [entrez]
AID - 10.2217/cer-2019-0017 [doi]
PST - ppublish
SO  - J Comp Eff Res. 2019 Jul;8(10):781-790. doi: 10.2217/cer-2019-0017. Epub 2019 Jun 
      6.