PMID- 31168382
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210112
IS  - 2053-3624 (Print)
IS  - 2053-3624 (Electronic)
IS  - 2053-3624 (Linking)
VI  - 6
IP  - 1
DP  - 2019
TI  - Non-steroidal anti-inflammatory drug use in acute myopericarditis: 12-month 
      clinical follow-up.
PG  - e000990
LID - 10.1136/openhrt-2018-000990 [doi]
LID - e000990
AB  - OBJECTIVE: Clinical data on the effect of non-steroidal anti-inflammatory drugs 
      (NSAIDs) in myopericarditis are limited. Since NSAIDs are standard therapy in 
      pericarditis, we retrospectively investigated their safety in myopericarditis. 
      METHODS: In a retrospective case-control study, we identified 60 patients with 
      myopericarditis from September 2010 to August 2017. Diagnosis was based on 
      clinical criteria, elevated high-sensitivity troponin T and cardiac magnetic 
      resonance imaging (CMR). All patients received standard heart failure therapy if 
      indicated. Twenty-nine patients (62%) received NSAIDs (acetylsalicylic acid: n=7, 
      average daily dose =1300 mg or ibuprofen: n=22, average daily dose =1500 mg) for 
      an average duration of 4 weeks. To create two cohorts with similar baseline 
      conditions, 15 patients were excluded. Three months after diagnosis, 29 patients 
      were re-evaluated by CMR to measure late gadolinium enhancement (LGE). RESULTS: 
      Baseline characteristics of those treated with or without NSAIDs were similar. 
      Mean age was 34 (+/-13) years, 6 (13%) were women. Mean left ventricular ejection 
      fraction (LVEF) was 56% (+/-5). 82 % of the patients (14 of 17) treated with NSAIDs 
      experienced a decrease in LGE at 3 months, while it was only 58 % (7 of 12) of 
      those without NSAIDs (p=0.15). At 12-month follow-up, one of the patients treated 
      without NSAIDs experienced polymorphic ventricular tachycardia (VT) with cardiac 
      arrest, while one of the patients with NSAIDs experienced non-sustained VT. 
      CONCLUSIONS: This is the first case-control study demonstrating that NSAIDs are 
      safe in patients with myopericarditis and preserved LVEF. Our data suggest that 
      this drug class should be tested prospectively in a large randomised clinical 
      trial.
FAU - Berg, Jan
AU  - Berg J
AUID- ORCID: 0000-0001-6771-4452
AD  - Cardiology, University Heart Center, Zurich, Switzerland.
FAU - Lovrinovic, Marina
AU  - Lovrinovic M
AD  - Cardiology, University Heart Center, Zurich, Switzerland.
FAU - Baltensperger, Nora
AU  - Baltensperger N
AD  - Cardiology, University Heart Center, Zurich, Switzerland.
FAU - Kissel, Christine K
AU  - Kissel CK
AD  - Cardiology, University Heart Center, Zurich, Switzerland.
FAU - Kottwitz, Jan
AU  - Kottwitz J
AD  - Cardiology, University Heart Center, Zurich, Switzerland.
FAU - Manka, Robert
AU  - Manka R
AD  - Cardiology, University Heart Center, Zurich, Switzerland.
FAU - Patriki, Dimitri
AU  - Patriki D
AUID- ORCID: 0000-0001-6364-0927
AD  - Cardiology, University Heart Center, Zurich, Switzerland.
FAU - Scherff, Frank
AU  - Scherff F
AD  - Cardiology, University Heart Center, Zurich, Switzerland.
FAU - Schmied, Christian
AU  - Schmied C
AD  - Cardiology, University Heart Center, Zurich, Switzerland.
FAU - Landmesser, Ulf
AU  - Landmesser U
AD  - Charite Universitatsmedizin, Campus Benjamin Franklin, Berlin, Germany.
FAU - Luscher, Thomas F
AU  - Luscher TF
AD  - Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland.
AD  - Royal Brompton and Harefield Hospitals and Imperial College, London, UK.
FAU - Heidecker, Bettina
AU  - Heidecker B
AUID- ORCID: 0000-0002-3811-7920
AD  - Cardiology, University Heart Center, Zurich, Switzerland.
AD  - Charite Universitatsmedizin, Campus Benjamin Franklin, Berlin, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190423
PL  - England
TA  - Open Heart
JT  - Open heart
JID - 101631219
PMC - PMC6519432
OTO - NOTNLM
OT  - late gadolinium enhancement
OT  - magnetic resonance imaging
OT  - myocardial inflammation
OT  - myocarditis
OT  - nonsteroidal anti-inflammatory drugs
COIS- Competing interests: None declared.
EDAT- 2019/06/07 06:00
MHDA- 2019/06/07 06:01
PMCR- 2019/04/23
CRDT- 2019/06/07 06:00
PHST- 2018/12/10 00:00 [received]
PHST- 2019/02/20 00:00 [revised]
PHST- 2019/03/04 00:00 [accepted]
PHST- 2019/06/07 06:00 [entrez]
PHST- 2019/06/07 06:00 [pubmed]
PHST- 2019/06/07 06:01 [medline]
PHST- 2019/04/23 00:00 [pmc-release]
AID - openhrt-2018-000990 [pii]
AID - 10.1136/openhrt-2018-000990 [doi]
PST - epublish
SO  - Open Heart. 2019 Apr 23;6(1):e000990. doi: 10.1136/openhrt-2018-000990. 
      eCollection 2019.