PMID- 31170970
OWN - NLM
STAT- MEDLINE
DCOM- 20191213
LR  - 20200225
IS  - 1476-511X (Electronic)
IS  - 1476-511X (Linking)
VI  - 18
IP  - 1
DP  - 2019 Jun 7
TI  - Flurbiprofen loaded ethosomes - transdermal delivery of anti-inflammatory effect 
      in rat model.
PG  - 133
LID - 10.1186/s12944-019-1064-x [doi]
LID - 133
AB  - BACKGROUND: Ethosomes have been widely used in Transdermal Drug Delivery System 
      (TDDS) as they increase the permeation of drug across the skin. METHODS: 
      Flurbiprofen loaded vesicular ethosomes were formulated, optimized and 
      characterized for particle size, entrapment efficiency, poly dispersive index 
      (PDI), microscopy using Atomic force microscopy (AFM), Scanning electron 
      microscope (SEM) and Transmission electron microscopy (TEM) and Interaction of 
      drug and excipients were studied using Fourier transform infra-red (FTIR) 
      spectroscopy, Differential scanning colorimetry (DSC), Thermo gravimetric 
      analysis (TGA). Further, ethosomal formulations of flurbiprofen were evaluated 
      for stability study of three months and in vitro drug permeation study was 
      carried out using albino rat skin. In addition, skin irritation test was 
      evaluated by Draize test and in vivo study of prepared formulation was examined 
      through paw edema assay by inducing carrageenan and cold plate method. RESULTS: 
      Amongst all formulations, EF5 formulation exhibited ideal surface morphology, 
      with maximum entrapment efficiency (95%) with optimal excipient concentration 
      i.e. 200 mg phospholipid and 35% ethanol. The ideal vesicle size was achieved as 
      162.2 +/- 2 nm, with zeta potential - 48.14 +/- 1.4 mV with the PDI of 0.341. 
      In-vitro permeation study shows a release of 82.56 +/- 2.11 g/cm(2) in 24 h and 
      transdermal flux was found as 226.1 mug/cm(2)/h. Cold plate test indicates that 
      the formulation EF5 showed a marked analgesic activity and Carrageenan induced 
      paw edema test indicates that the formulation EF5 inhibits the increase in paw 
      edema. Ethosomal suspension at 4  degrees C showed maximum stability. CONCLUSIONS: The 
      overall study concluded that this ethosomal approach offers a new delivery system 
      for sustained and targeted delivery for flurbiprofen.
FAU - Paliwal, Sarvesh
AU  - Paliwal S
AD  - Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, 304022, 
      India.
FAU - Tilak, Amita
AU  - Tilak A
AD  - Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, 304022, 
      India.
FAU - Sharma, Jaiprakash
AU  - Sharma J
AD  - Department of Pharmacy, SMS Medical College, Banasthali, Rajasthan, India.
FAU - Dave, Vivek
AU  - Dave V
AUID- ORCID: 0000-0001-7337-6365
AD  - Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, 304022, 
      India. vivekdave1984@gmail.com.
FAU - Sharma, Swapnil
AU  - Sharma S
AD  - Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, 304022, 
      India.
FAU - Yadav, Renubala
AU  - Yadav R
AD  - Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, 304022, 
      India.
FAU - Patel, Saraswati
AU  - Patel S
AD  - Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, 304022, 
      India.
FAU - Verma, Kanika
AU  - Verma K
AD  - Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, 304022, 
      India.
FAU - Tak, Kajal
AU  - Tak K
AD  - Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, 304022, 
      India.
LA  - eng
PT  - Journal Article
DEP - 20190607
PL  - England
TA  - Lipids Health Dis
JT  - Lipids in health and disease
JID - 101147696
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Liposomes)
RN  - 0 (Phospholipids)
RN  - 3K9958V90M (Ethanol)
RN  - 5GRO578KLP (Flurbiprofen)
SB  - IM
MH  - Administration, Cutaneous
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - *Drug Delivery Systems
MH  - Ethanol/chemistry
MH  - Flurbiprofen/chemistry/*pharmacology
MH  - Humans
MH  - Inflammation/*drug therapy/pathology
MH  - Liposomes/chemistry/pharmacology
MH  - Phospholipids/chemistry
MH  - Rats
MH  - Skin/drug effects
PMC - PMC6554971
OTO - NOTNLM
OT  - Ethosomes
OT  - Flurbiprofen
OT  - Transdermal delivery
EDAT- 2019/06/07 06:00
MHDA- 2019/12/18 06:00
PMCR- 2019/06/07
CRDT- 2019/06/08 06:00
PHST- 2019/01/03 00:00 [received]
PHST- 2019/05/06 00:00 [accepted]
PHST- 2019/06/08 06:00 [entrez]
PHST- 2019/06/07 06:00 [pubmed]
PHST- 2019/12/18 06:00 [medline]
PHST- 2019/06/07 00:00 [pmc-release]
AID - 10.1186/s12944-019-1064-x [pii]
AID - 1064 [pii]
AID - 10.1186/s12944-019-1064-x [doi]
PST - epublish
SO  - Lipids Health Dis. 2019 Jun 7;18(1):133. doi: 10.1186/s12944-019-1064-x.