PMID- 31171714
OWN - NLM
STAT- MEDLINE
DCOM- 20200806
LR  - 20200806
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 39
IP  - 6
DP  - 2019 Jun 28
TI  - LncRNA PTCSC3 inhibits cell proliferation in laryngeal squamous cell carcinoma by 
      down-regulating lncRNA HOTAIR.
LID - BSR20182362 [pii]
LID - 10.1042/BSR20182362 [doi]
AB  - It is known that lncRNA PTCSC3 inhibits thyroid cancer and glioma and STAT3 
      promotes cancer development. We, in the present study, investigated the potential 
      involvement of PTCSC3 in laryngeal squamous cell carcinoma (LSCC) and explored 
      its interactions with STAT3. In the present study, we showed that plasma PTCSC3 
      was down-regulated in early stage LSCC patients, and the down-regulation of 
      PTCSC3 separated in early stage LSCC patients from control group. LncRNA HOTAIR 
      was up-regulated in early stage LSCC patients and was significantly and inversely 
      correlated with PTCSC3 in LSCC patients. PTCSC3 overexpression led to the 
      inhibition of HOTAIR, while PTCSC3 expression was not significantly affected by 
      HOTAIR overexpression. PTCSC3 overexpression mediated the inhibited, while HOTAIR 
      overexpression mediated the promoted proliferation of LSCC cells. However, cell 
      invasion and migration were not significantly affected by PTCSC3 overexpression. 
      In addition, HOTAIR overexpression reduced the inhibitory effects of PTCSC3 
      overexpression on cancer cell proliferation. Moreover, PTCSC3 overexpression 
      mediated the down-regulation of STAT3 and STAT3 overexpression mediated the 
      up-regulation of HOTAIR. Therefore, PTCSC3 may negatively interact with HOTAIR 
      through STAT3 to inhibit LSCC cell proliferation.
CI  - (c) 2019 The Author(s).
FAU - Xiao, Dong
AU  - Xiao D
AD  - Department of Otolaryngology, The First Hospital, Jilin University, Changchun 
      City 130021, Jilin Province, P.R. China.
FAU - Cui, Xiangyan
AU  - Cui X
AD  - Department of Otolaryngology, The First Hospital, Jilin University, Changchun 
      City 130021, Jilin Province, P.R. China.
FAU - Wang, Xin
AU  - Wang X
AUID- ORCID: 0000-0003-0641-0812
AD  - Department of Otolaryngology, The First Hospital, Jilin University, Changchun 
      City 130021, Jilin Province, P.R. China ehxpi03@163.com.
LA  - eng
PT  - Journal Article
DEP - 20190628
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (HOTAIR long untranslated RNA, human)
RN  - 0 (Ptcsc3 untranslated RNA, human)
RN  - 0 (RNA, Long Noncoding)
RN  - 0 (RNA, Untranslated)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (STAT3 protein, human)
SB  - IM
MH  - Adult
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - Cell Proliferation
MH  - Down-Regulation
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - RNA, Long Noncoding/*genetics
MH  - RNA, Untranslated/*genetics
MH  - STAT3 Transcription Factor/genetics
MH  - Up-Regulation
PMC - PMC6597852
OTO - NOTNLM
OT  - laryngeal squamous cell carcinoma
OT  - lncRNA HOTAIR
OT  - lncRNA PTCSC3
OT  - proliferation
COIS- The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2019/06/07 06:00
MHDA- 2020/08/07 06:00
PMCR- 2019/06/28
CRDT- 2019/06/08 06:00
PHST- 2018/12/21 00:00 [received]
PHST- 2019/05/21 00:00 [revised]
PHST- 2019/06/02 00:00 [accepted]
PHST- 2019/06/07 06:00 [pubmed]
PHST- 2020/08/07 06:00 [medline]
PHST- 2019/06/08 06:00 [entrez]
PHST- 2019/06/28 00:00 [pmc-release]
AID - BSR20182362 [pii]
AID - 10.1042/BSR20182362 [doi]
PST - epublish
SO  - Biosci Rep. 2019 Jun 28;39(6):BSR20182362. doi: 10.1042/BSR20182362. Print 2019 
      Jun 28.