PMID- 31171764
OWN - NLM
STAT- MEDLINE
DCOM- 20200116
LR  - 20221207
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 25
DP  - 2019 Jun 7
TI  - Efficacy and Safety of "On-Demand" Dapoxetine in Treatment of Patients with 
      Premature Ejaculation: A Meta-Analysis.
PG  - 4225-4232
LID - 10.12659/MSM.913606 [doi]
AB  - BACKGROUND The aim of this study was to assess the efficacy and safety of 
      "on-demand" dapoxetine in the treatment of premature ejaculation (PE). MATERIAL 
      AND METHODS We performed a meta-analysis of intravaginal ejaculatory latency time 
      (IELT), patient-reported global impression of change (PGIC), perceived control 
      over ejaculation (PCOE), and drug-related adverse effects (AEs). We searched 
      Medline, PubMed, Embase, CNKI, Wanfang, and VIP databases up to May 30, 2018 with 
      the following search terms: "dapoxetine" or "SSRIs" and "premature ejaculation" 
      or "sexual dysfunction". RESULTS Our analysis included 11 RCTs (8521 cases and 
      4338 controls). We found that IELT, PGIC, and PCOE in PE patients with 
      "on-demand" dapoxetine were significantly higher than in the control group, and 
      we observed higher proportions in 60 mg vs. 30 mg dapoxetine. The AEs were mild 
      and tolerable. CONCLUSIONS "On-demand" dapoxetine is effective and safe for 
      patients with PE, and a dose of 60 mg may be more effective than 30 mg.
FAU - Du, Yuefeng
AU  - Du Y
AD  - Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi, China (mainland).
AD  - Oncology Research Lab, Key Laboratory of Environment and Genes Related to 
      Diseases, Ministry of Education, Xi'an, Shaanxi, China (mainland).
FAU - Jiang, Yumei
AU  - Jiang Y
AD  - Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi, China (mainland).
AD  - Oncology Research Lab, Key Laboratory of Environment and Genes Related to 
      Diseases, Ministry of Education, Xi'an, Shaanxi, China (mainland).
FAU - Zhang, Jing
AU  - Zhang J
AD  - Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi, China (mainland).
FAU - Tian, Ge
AU  - Tian G
AD  - Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi, China (mainland).
FAU - Zhang, Na
AU  - Zhang N
AD  - Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi, China (mainland).
FAU - Wu, Dapeng
AU  - Wu D
AD  - Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi, China (mainland).
FAU - Bai, Xiaojing
AU  - Bai X
AD  - Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, Shaanxi, China (mainland).
AD  - Oncology Research Lab, Key Laboratory of Environment and Genes Related to 
      Diseases, Ministry of Education, Xi'an, Shaanxi, China (mainland).
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20190607
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (Benzylamines)
RN  - 0 (Naphthalenes)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - GB2433A4M3 (dapoxetine)
SB  - IM
MH  - Adult
MH  - Benzylamines/*administration & dosage/pharmacology
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Ejaculation/drug effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Naphthalenes/*administration & dosage/pharmacology
MH  - Premature Ejaculation/*drug therapy
MH  - Selective Serotonin Reuptake Inhibitors/therapeutic use
MH  - Treatment Outcome
PMC - PMC6570993
COIS- Competing interests None.
EDAT- 2019/06/07 06:00
MHDA- 2020/01/17 06:00
PMCR- 2019/06/07
CRDT- 2019/06/08 06:00
PHST- 2019/06/08 06:00 [entrez]
PHST- 2019/06/07 06:00 [pubmed]
PHST- 2020/01/17 06:00 [medline]
PHST- 2019/06/07 00:00 [pmc-release]
AID - 913606 [pii]
AID - 10.12659/MSM.913606 [doi]
PST - epublish
SO  - Med Sci Monit. 2019 Jun 7;25:4225-4232. doi: 10.12659/MSM.913606.