PMID- 31172715
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2092-7355 (Print)
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Linking)
VI  - 11
IP  - 4
DP  - 2019 Jul
TI  - House Dust Mite Allergy Under Changing Environments.
PG  - 450-469
LID - 10.4168/aair.2019.11.4.450 [doi]
AB  - Environmental variations induced by industrialization and climate change 
      partially explain the increase in prevalence and severity of allergic disease. 
      One possible mechanism is the increase in allergen production leading to more 
      exposure and sensitization in susceptible individuals. House dust mites (HDMs) 
      are important sources of allergens inducing asthma and rhinitis, and 
      experimentally they have been demonstrated to be very sensitive to 
      microenvironment modifications; therefore, global or regional changes in 
      temperature, humidity, air pollution or other environmental conditions could 
      modify natural HDM growth, survival and allergen production. There is evidence 
      that sensitization to HDMs has increased in some regions of the world, especially 
      in the subtropical and tropical areas; however, the relationship of this increase 
      with environmental changes is not so clear as has reported for pollen allergens. 
      In this review, we address this point and explore the effects of current and 
      predicted environmental changes on HDM growth, survival and allergen production, 
      which could lead to immunoglobulin E (IgE) sensitization and allergic disease 
      prevalence. We also assess the role of adjuvants of IgE responses, such as air 
      pollution and helminth infections, and discuss the genetic and epigenetic aspects 
      that could influence the adaptive process of humans to drastic and relatively 
      recent environmental changes we are experiencing.
CI  - Copyright (c) 2019 The Korean Academy of Asthma, Allergy and Clinical Immunology . 
      The Korean Academy of Pediatric Allergy and Respiratory Disease.
FAU - Acevedo, Nathalie
AU  - Acevedo N
AUID- ORCID: 0000-0002-5154-2964
AD  - Institute for Immunological Research, University of Cartagena, Cartagena de 
      Indias, Colombia.
FAU - Zakzuk, Josefina
AU  - Zakzuk J
AUID- ORCID: 0000-0002-6007-5376
AD  - Institute for Immunological Research, University of Cartagena, Cartagena de 
      Indias, Colombia.
FAU - Caraballo, Luis
AU  - Caraballo L
AUID- ORCID: 0000-0002-5204-1109
AD  - Institute for Immunological Research, University of Cartagena, Cartagena de 
      Indias, Colombia. lcaraballog@unicartagena.edu.co.
LA  - eng
GR  - 806-2018/Colciencias/Colombia
PT  - Journal Article
PT  - Review
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC6557771
OTO - NOTNLM
OT  - Environment
OT  - allergy
OT  - house dust mites
COIS- There are no financial or other issues that might lead to conflict of interest.
EDAT- 2019/06/07 06:00
MHDA- 2019/06/07 06:01
PMCR- 2019/07/01
CRDT- 2019/06/08 06:00
PHST- 2019/02/28 00:00 [received]
PHST- 2019/03/12 00:00 [revised]
PHST- 2019/03/15 00:00 [accepted]
PHST- 2019/06/08 06:00 [entrez]
PHST- 2019/06/07 06:00 [pubmed]
PHST- 2019/06/07 06:01 [medline]
PHST- 2019/07/01 00:00 [pmc-release]
AID - 11.450 [pii]
AID - 10.4168/aair.2019.11.4.450 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2019 Jul;11(4):450-469. doi: 
      10.4168/aair.2019.11.4.450.