PMID- 31172718 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 2092-7355 (Print) IS - 2092-7363 (Electronic) IS - 2092-7355 (Linking) VI - 11 IP - 4 DP - 2019 Jul TI - Reduction Rate of Specific IgE Level as a Predictor of Persistent Egg Allergy in Children. PG - 498-507 LID - 10.4168/aair.2019.11.4.498 [doi] AB - PURPOSE: Egg is the most common food allergen in infants. However, the natural course of egg allergy has not been fully elucidated. This study aimed to describe clinical characteristics and to identify prognostic factors associated with tolerance acquisition of immunoglobulin E (IgE)-mediated egg allergy in children. METHODS: Children who underwent more than 1 follow-up egg white-specific immunoglobulin E (EWsIgE) test between November 2005 and November 2015 at -Severance Children's Hospital were assessed. Children were diagnosed as having IgE-mediated egg allergy based on immediate allergic reaction after egg consumption and an EWsIgE level of > 0.35 kU/L. The children were divided into "tolerant" and "persistent" groups according to tolerance acquisition defined as egg consumption without adverse allergic reactions. RESULTS: Of 124 participants, egg allergy resolved in 101 (81.5%) children. The persistent group had more atopic dermatitis (P = 0.039), and more wheat (P = 0.009) and peanut (P = 0.012) allergies compared to the tolerant group. The EWsIgE levels at diagnosis (EWsIgE(diag)) were higher in the persistent group than in the tolerant group (P = 0.001). The trend of the EWsIgE levels in the tolerant group decreased markedly over time compared to the persistent group (P < 0.001). In predicting egg allergy tolerance acquisition, the reduction rate of EWsIgE level after 12 months from diagnosis (DeltaEWsIgE(12mo)) tended to be more accurate than EWsIgE(diag) (area under the curve: 0.835 vs. 0.731). When DeltaEWsIgE(12mo) was >/= 30%, tolerance acquisition was more frequent than that of < 30% (91.9% vs. 57.9%; P < 0.001). CONCLUSIONS: DeltaEWsIgE(12mo) can be used as an early independent predictor of tolerance acquisition of IgE-mediated egg allergy in children. CI - Copyright (c) 2019 The Korean Academy of Asthma, Allergy and Clinical Immunology . The Korean Academy of Pediatric Allergy and Respiratory Disease. FAU - Kim, Jong Deok AU - Kim JD AUID- ORCID: 0000-0002-4266-5655 AD - Department of Pediatrics, Severance Hospital, Institute of Allergy, Institute for Immunology and Immunological Diseases, Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. AD - Department of Pediatrics, Hanyang University College of Medicine, Seoul, Korea. FAU - Kim, Soo Yeon AU - Kim SY AUID- ORCID: 0000-0003-4965-6193 AD - Department of Pediatrics, Severance Hospital, Institute of Allergy, Institute for Immunology and Immunological Diseases, Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. FAU - Kwak, Eun Ji AU - Kwak EJ AD - Department of Pediatrics, Severance Hospital, Institute of Allergy, Institute for Immunology and Immunological Diseases, Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. FAU - Sol, In Suk AU - Sol IS AUID- ORCID: 0000-0003-2470-9682 AD - Department of Pediatrics, Severance Hospital, Institute of Allergy, Institute for Immunology and Immunological Diseases, Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. FAU - Kim, Min Jung AU - Kim MJ AUID- ORCID: 0000-0002-5634-9709 AD - Department of Pediatrics, Severance Hospital, Institute of Allergy, Institute for Immunology and Immunological Diseases, Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. FAU - Kim, Yoon Hee AU - Kim YH AUID- ORCID: 0000-0002-2149-8501 AD - Department of Pediatrics, Severance Hospital, Institute of Allergy, Institute for Immunology and Immunological Diseases, Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. FAU - Kim, Kyung Won AU - Kim KW AUID- ORCID: 0000-0003-4529-6135 AD - Department of Pediatrics, Severance Hospital, Institute of Allergy, Institute for Immunology and Immunological Diseases, Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. kwkim@yuhs.ac. FAU - Sohn, Myung Hyun AU - Sohn MH AUID- ORCID: 0000-0002-2478-487X AD - Department of Pediatrics, Severance Hospital, Institute of Allergy, Institute for Immunology and Immunological Diseases, Severance Biomedical Science Institute, Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea. LA - eng GR - 6-2016-0140/YUCM/Yonsei University College of Medicine/Korea GR - 2017-0-00599/IITP/Institute for Information and communications Technology Promotion/Korea PT - Journal Article PL - Korea (South) TA - Allergy Asthma Immunol Res JT - Allergy, asthma & immunology research JID - 101518382 PMC - PMC6557778 OTO - NOTNLM OT - Egg hypersensitivity OT - child OT - egg white OT - food allergy OT - immunoglobulin E COIS- There are no financial or other issues that might lead to conflict of interest. EDAT- 2019/06/07 06:00 MHDA- 2019/06/07 06:01 PMCR- 2019/07/01 CRDT- 2019/06/08 06:00 PHST- 2019/01/03 00:00 [received] PHST- 2019/03/16 00:00 [revised] PHST- 2019/03/18 00:00 [accepted] PHST- 2019/06/08 06:00 [entrez] PHST- 2019/06/07 06:00 [pubmed] PHST- 2019/06/07 06:01 [medline] PHST- 2019/07/01 00:00 [pmc-release] AID - 11.498 [pii] AID - 10.4168/aair.2019.11.4.498 [doi] PST - ppublish SO - Allergy Asthma Immunol Res. 2019 Jul;11(4):498-507. doi: 10.4168/aair.2019.11.4.498.